Chuang Xu
Internal medicineEndocrinologyUnfolded protein responseEndoplasmic reticulumAdipose tissueChemistryApoptosisGluconeogenesisOxidative stressAdipocyteORAI1Liver injuryKetosisInflammationNonalcoholic fatty liver diseaseAntioxidantMalondialdehydeFatty liverLipid metabolismReactive oxygen speciesGlutathioneFatty acidMetabolismMedicineACACABiologyCell biologyPharmacologyCaspase
29Publications
8H-index
162Citations
Publications 31
Newest
#1Xinru MaH-Index: 2
Last. Wei YangH-Index: 5
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Hindgut microorganisms in newborn calves play an important role in the development of immunity and metabolism, and optimization of performance. However, knowledge of the extent to which microbiome colonization of the calf intestine is dependent on maternal characteristics is limited. In this study, placenta, umbilical cord, amniotic fluid, colostrum, cow feces, and calf meconium samples were collected from 6 Holstein cow-calf pairs. Microbial composition was analyzed by 16S rRNA gene high-throug...
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#1Yuanyuan ChenH-Index: 2
#2Yan TangH-Index: 3
Last. Hao Dong
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ABSTRACT null null Bovine mammary epithelial cells undergo an increase in metabolic rate, mitochondrial dysfunction, and oxidative stress after calving. Nuclear factor erythroid 2-related factor 2 (NFE2L2), a master regulator of cellular redox homeostasis, plays crucial roles in the regulation of mitochondrial function. The objective of this study was to investigate the role of NFE2L2 on mitochondrial function in bovine mammary epithelial cells under hyperlipidemic conditions. Three experiments ...
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#1Ming LiH-Index: 7
#2Wei YangH-Index: 8
Last. Xilin Hou
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Fatty liver is a common metabolic disorder afflicting dairy cows during the periparturient period and is closely associated with endoplasmic reticulum (ER) stress. The onset of ER stress in humans and mice alters hepatic lipid metabolism, but it is unknown if such event contributes to fatty liver in dairy cows soon after parturition. ORAI1 is a key component of the store-operated Ca2+ entry mechanism regulating cellular Ca2+ balance. The purpose of this study was to investigate the role of ORAI1...
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#1Xudong SunH-Index: 8
#2Renxu Chang (HAU: Hunan Agricultural University)H-Index: 2
Last. Chuang XuH-Index: 8
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BACKGROUND Bovine mammary epithelial cells after calving undergo serious metabolic challenges and oxidative stress both of which could compromise autophagy. Transcription factor EB (TFEB)-mediated autophagy is an important cytoprotective mechanism against oxidative stress. However, effects of TFEB-mediated autophagy on the oxidative stress of bovine mammary epithelial cells remain unknown. Therefore, the main aim of the study was to investigate the role of TFEB-mediated autophagy in bovine mamma...
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#1Qiushi XuH-Index: 3
#2Yunhui FanH-Index: 2
Last. Chuang XuH-Index: 8
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ABSTRACT Adipose tissue concentration of reactive oxygen species (ROS) increases in dairy cows with ketosis, suggesting that the tissue experiences oxidative stress. Autophagy, an adaptive response to cellular stress, has been shown to promote survival and plays a critical role in antioxidant responses. Dysregulation of adenosine 5′-monophosphate-activated protein kinase (AMPK) is closely related to antioxidant responses and autophagy of adipocytes in animal models of metabolic disorders, but it...
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#1Qiushi XuH-Index: 3
#2Yunhui FanH-Index: 2
Last. Chuang XuH-Index: 8
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ABSTRACT Preadipocyte proliferation and differentiation are critical for normal adipose tissue development, including achieving a mature phenotype, characterized by its ability to accumulate triacylglycerol and release fatty acids. In nonruminants, it is well known that all-trans retinoic acid (ATRA), the most-active form of vitamin A, helps regulate proliferation, differentiation, and apoptosis in several types of cells including adipocytes. The purpose of this study was to evaluate the effect ...
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#1Qiushi XuH-Index: 3
#2Yunhui FanH-Index: 2
Last. Chuang XuH-Index: 8
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Aloin, a naturally occurring anthraquinone glycoside derived from the Aloe species, has antioxidant and anti-inflammatory activities, but its role in non-alcoholic steatohepatitis (NASH) remains unknown. This study was designed to investigate the anti-inflammatory, antioxidant, and anti-apoptotic effects of aloin and the underlying mechanisms during NASH. Wild-type or nuclear erythroid 2–related factor 2 (Nrf2) knock-out (KO) mice were fed a choline-deficient, L-amino acid-defined, high-fat (CDA...
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#1Xudong SunH-Index: 8
#2Yan TangH-Index: 3
Last. Chuang XuH-Index: 8
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ABSTRACT Ketosis is a serious metabolic disorder characterized by systemic and hepatic oxidative stress, inflammation, and apoptosis, as well as reduced milk yield. Because of the paucity of data on mammary responses during ketosis, the aim of this study was to evaluate alterations in oxidative stress, NF-κB signaling, NLRP3 inflammasome, and caspase apoptotic pathways in mammary gland of dairy cows with ketosis. Blood, mammary gland tissue, and milk samples were collected from healthy cows [Con...
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#1Yunlong BaiH-Index: 3
#2Feng ZhangH-Index: 1
Last. Cheng XiaH-Index: 1
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The metabolism of dairy cows with inactive ovaries differs from that of healthy dairy cows. However, the molecular mechanisms underpinning these physiological and metabolic changes remain unclear. The purpose of this study was to investigate follicular fluid metabolite changes in dairy cows with inactive ovaries. Untargeted metabolomics technology and multivariate statistical analysis were used to screen differential metabolites in follicular fluid samples between inactive ovaries and estrus cow...
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