Wolfram E. Nolten
University of Cincinnati Academic Health Center
ExcretionCircadian rhythmInternal medicineEndocrinologySerum albuminRadioimmunoassayChemistryMorningMedroxyprogesterone acetateBlood plasmaPituitary glandAndrogenAdrenal cortexAldosteroneHydrocortisoneThirstPregnancyAntidiureticDihydrotestosteroneCorticosteroneCortisoneAdrenocorticotropic hormoneDiethylstilbestrolPopulationAndrogen biosynthetic processCortisol secretionConceptusSodiumTestosteroneCortisol awakening responseHomeostasisHormoneMedicineAlcohol and cortisol
Publications 5
#1Wolfram E. NoltenH-Index: 3
#2Edward N. EhrlichH-Index: 2
During the course of normal gestation, major changes in volume, distribution, and concentration of body fluids occur in the maternal organism, in order to meet the requirements of the developing conceptus. In pregnant as in nonpregnant subjects, sodium and water balance are governed by hypothalamic centers that control the release of antidiuretic hormone and influence thirst sensation, by renal adjustments of sodium and fluid excretion, and by secretion of gluco- and mineralocorticoids by the ad...
Plasma concentrations of cortisol and corticosteroid-binding globulin are elevated substantially in pregnancy; only the free cortisol fraction is biologically active. Previous suggestions that plasma free cortisol increased above nongravid levels in pregnancy were difficult to reconcile with the absence of manifestations of hypercortisolism. Furthermore, any such elevation should be associated with some alteration in the regulation of cortisol secretion. Therefore, the physiology of cortisol sec...
#1Wolfram E. NoltenH-Index: 3
Last. Edward N. EhrlichH-Index: 16
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#1Wolfram E. Nolten (University of Cincinnati Academic Health Center)H-Index: 3
#2Leon J. Sholiton (University of Cincinnati Academic Health Center)H-Index: 18
Last. Emile E. Werk (University of Cincinnati Academic Health Center)H-Index: 15
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Alterations in the metabolism of testosterone (T) and dihydrotestosterone (DHT) induced by diethylstilbestrol (DES) or medroxyprogesterone acetate (MPA) could account for the beneficial therapeutic effect of these agents in prostatic carcinoma. To investigate this possibility we studied plasma kinetics of T and DHT in 17 elderly patients with prostatic carcinoma, before and after treatment with DES (1 or 5 mg/d) or MPA (10 or 30 mg/d) for 30 days. Metabolic clearance rates (MCR) were determined ...
#1L S Srivastava (University of Cincinnati Academic Health Center)H-Index: 17
#2Emile E. Werk (University of Cincinnati Academic Health Center)H-Index: 15
Last. Harvey C. Knowles (University of Cincinnati Academic Health Center)H-Index: 10
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A radioimmunoassay for measurement of cortisone in plasma has been developed utilizing rabbit anti-sera against a cortisone-bovine serum albumin complex. To insure specificity thin layer chromatography was used because unchromatographed samples resulted in 10–20% higher values than the chromatographed, even though the cross reactivity with cortisol was only 0.68% and with corticosterone 1.15%. The sensitivity of the assay varies 50–79 pg with recovery of cortisone added to plasma found to be 94....
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