Dangdang Li
Jilin University
Internal medicineEndocrinologyProinflammatory cytokineChemistryImmunologySuperoxide dismutaseOxidative stressHepatocyteKetosisInflammationAntioxidantMalondialdehydeGlutathione peroxidaseCatalasePyrrolidine dithiocarbamateKetone bodiesLDL receptorReactive oxygen speciesBiochemistryApolipoprotein EOxidative phosphorylationSignal transductionApolipoprotein BVery low-density lipoproteinBiology
Publications 3
#1Xiaoxia Shi (JLU: Jilin University)H-Index: 8
#2Dangdang Li (JLU: Jilin University)H-Index: 3
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
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Abstract Dairy cows with fatty liver or ketosis exhibit hyperketonemia, oxidative stress, and a low rate of very low density lipoprotein (VLDL) assembly, and there may be a potential link among these characteristics. Therefore, the objective of this study was to determine the effect of acetoacetic acid (AcAc) on the assembly of VLDL in cow hepatocytes. Cultured cow hepatocytes were treated with different concentrations of AcAc with or without N-acetylcysteine (NAC, an antioxidant). AcAc treatmen...
9 CitationsSource
Abstract Non-esterified fatty acids (NEFAs) are important induction factors of inflammatory responses in some metabolic diseases. High plasma levels of NEFAs and oxidative stress exist in the dairy cows with ketosis. The aim of this study was to investigate whether high levels of NEFAs can induce inflammatory response and the specific molecular mechanism in the hepatocytes of dairy cow. In vitro , primary cultured bovine hepatocytes were treated with different concentrations of NEFAs, PDTC (an N...
57 CitationsSource
Background/Aims: s-hydroxybutyrate (BHBA) is the major component of ketone bodies in ketosis. Dairy cows with ketosis often undergo oxidative stress. BHBA is related to the inflammation involved in other diseases of dairy cattle. However, whether BHBA can induce inflammatory injury in dairy cow hepatocytes and the potential mechanism of this induction are not clear. The NF-κB pathway plays a vital role in the inflammatory response. Methods: Therefore, this study evaluated the oxidative stress, p...
59 CitationsSource