Libin Ma
Zhejiang University
Messenger RNACell cycle checkpointAkt/PKB signaling pathwayInternal medicineCell migrationCellRenal functionChemistryIn vivoCell countingWestern blotDU145Vascular endothelial growth factorMothers against decapentaplegic homolog 7PTENMetastasis suppressorEmodinMatrigelMetastasisLNCaPProstate cancerCreatinineBladder cancerAngiogenesisMMP2SMADCell cycleBladder cancer cellRenal fibrosisCancer researchTransfectionNephrologyCarcinogenesisAndrogen receptorCell growthMedicineProtein kinase BBiologyCell biologyCancer cellPharmacology
Publications 5
#1Libin Ma (ZJU: Zhejiang University)H-Index: 3
#2Kang Jiang (ZJU: Zhejiang University)H-Index: 1
Last. Gang Deng (ZJU: Zhejiang University)H-Index: 1
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The aim of the present study was to explore the mechanism by which Notch1‑small activating (sa)RNA restored androgen sensitivity in human metastatic castration‑resistant prostate cancer (CRPC). After transfection of Notch1‑saRNA‑1480 in PC3 cells, the expression of Notch1 and androgen receptor (AR) was investigated by reverse transcription quantitative PCR (RT‑qPCR) and western blotting. Furthermore, the protein expression level of vascular endothelial growth factor (VEGF) was measured. Then, fl...
1 CitationsSource
#1Libin Ma (ZJU: Zhejiang University)H-Index: 3
#2Huadong He (ZJU: Zhejiang University)H-Index: 1
Last. Gang Deng (ZJU: Zhejiang University)H-Index: 1
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Family with sequence similarity 46 member C (FAM46C) is a non-canonical poly(A) polymerase that is associated with tumorigenesis. However, its role in prostate cancer development is not fully understood. Herein, we determined expression pattern of FAM46C in prostate cancer and further identified its effect on the tumorigenesis and chemosensitivity. FAM46C expression was decreased in prostate cancer tissues and cell lines compared with corresponding controls. FAM46C expression was significantly a...
2 CitationsSource
#1Libin Ma (ZJU: Zhejiang University)H-Index: 3
#2Hua Li (ZJU: Zhejiang University)H-Index: 1
Last. Gang Deng (Nanjing Medical University)H-Index: 2
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Background Emodin is a natural active component extracted from Chinese herbs. In this study, we investigated the therapeutic effect of emodin on surgery-induced renal fibrosis in rat. Moreover, the function of Smad ubiquitination regulatory factor 2 (Smurf 2) was further studied in vitro.
23 CitationsSource
#1Gang DengH-Index: 1
#2Xiaoliang Zheng (Academy of Medical Sciences, United Kingdom)H-Index: 12
Last. Shenglin MaH-Index: 14
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: Notch1 is a type-1 transmembrane receptor which has been demonstrated to be involved in proliferation in various organisms. A number of studies have proposed that Notch signaling may be aberrantly activated, thus contributing to development, invasion and metastasis in a variety of human cancers. In the present study, the function and mechanism of Notch1 in human prostate cancer (PCa) LNCaP cells in vitro was investigated. Notch1 and cleaved-Notch1 expression were evaluated in human PCa cell li...
5 CitationsSource
#1Libin Ma (ZJU: Zhejiang University)H-Index: 3
#2Kean Chen (ZJNU: Zhejiang Chinese Medical University)H-Index: 2
Last. Zhijian Yu (Nanjing Medical University)H-Index: 2
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Emodin exhibits anti-proliferative effects in numerous cancer cell lines via different mechanisms. The present study aimed to study the effects and underlying molecular mechanisms of emodin on bladder cancer cells. We treated two bladder cancer cell lines, T24 and 5637, with different concentrations of emodin (20, 40 and 80 µmol/L) or DMSO (Control). We analyzed the biological effects of emodin on cell growth, invasion, as well as the mRNA and protein expression of Notch1, Jagged1, VEGF, VEGFR2 ...
1 Citations