Brennie E. Hackley
United States Army Medical Research Institute of Chemical Defense
PathophysiologyH&E stainBiomedical engineeringSurgeryPathologyPulse durationVaporizationImmunologyTetrazolium chlorideHuman skinDermisDebridementWeanlingHairlessWound healingSulfur mustardEpidermisCarbon dioxide laserBlistersStainTransplantationPapillary dermisLaserMedicineStainingPulse (signal processing)Biology
Publications 3
Abstract Background: CO 2 laser energy is absorbed by water, which is present in all tissue. The depth of penetration of CO 2 lasers is narrow with minimal reflection, scatter, or transmission. However, thermal damage has limited the usefulness of conventional, continuous-wave CO 2 lasers for debridement as demonstrated by wound healing studies. The development of high-energy CO 2 lasers, with pulse durations that are less than the thermal relaxation time of tissue, have made vaporization of ski...
#1Kathleen J. Smith (United States Army Medical Research Institute of Chemical Defense)H-Index: 2
#2Robert P. Casillas (United States Army Medical Research Institute of Chemical Defense)H-Index: 20
Last. Brennie E. Hackley (United States Army Medical Research Institute of Chemical Defense)H-Index: 3
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Abstract In an effort to understand the pathophysiology of sulfur mustard (2,2′ dichlorodiethyl sulfide, HD)-induced cutaneous lesions, a number of animal models have been used. Animal models have been and will continue to be used in the development of therapeutic strategies to protect against and/or moderate lesions, and to potentiate wound healing after HD exposure. Upon reviewing the histopathologic features seen after HD-exposure, we propose roles for different animal models in HD-research. ...
#1Kathleen J. SmithH-Index: 34
#2John S. GrahamH-Index: 18
Last. Charles G. HurstH-Index: 9
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We read with interest the articles by Fitzpatrick et al1,2in recent issues of theArchives. We recently evaluated the histopathologic features seen in the skin of a weanling pig at 30 to 60 minutes after laser debridement using 1, 2, and 3 passes of a pulsed carbon dioxide laser (Tru-Pulse, Tissue Technologies, Albuquerque, NM). In addition to routine hematoxylin-eosin staining, we used nitroblue— tetrazolium chloride (NBTC) staining, a vital tissue stain using a mitrochondrial oxidation-reductio...
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