K. Gowthamarajan
Jagadguru Sri Shivarathreeswara University
Box–Behnken designNanotechnologyBioavailabilityChemistryParticle sizeFriabilityMaterials scienceIn vitroIn vivoCurcuminDrug deliveryDrugOxaliplatinChromatographyPulmonary surfactantMedicineNasal administrationZeta potentialDissolutionPharmacology
Publications 47
#1Jaskiran Kaur (LPU: Lovely Professional University)H-Index: 3
#2Vijay Mishra (LPU: Lovely Professional University)H-Index: 22
Last. K. Gowthamarajan (Jagadguru Sri Shivarathreeswara University)H-Index: 17
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Abstract Amphiphilic block copolymers are widely utilized in the design of formulations owing to their unique physicochemical properties, flexible structures and functional chemistry. Amphiphilic polymeric micelles (APMs) formed from such copolymers have gained attention of the drug delivery scientists in past few decades for enhancing the bioavailability of lipophilic drugs, molecular targeting, sustained release, stimuli-responsive properties, enhanced therapeutic efficacy and reducing drug as...
#1Singh Sonia (GLA University)
#2Bajpai Meenakshi (GLA University)
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#1Radhakrishnan Arun (Jagadguru Sri Shivarathreeswara University)H-Index: 1
#2K. Gowthamarajan (Jagadguru Sri Shivarathreeswara University)H-Index: 17
Last. Subramaniam K J Thirumalai (Jagadguru Sri Shivarathreeswara University)
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#1Shanmugam Ramaswamy (Jagadguru Sri Shivarathreeswara University)H-Index: 3
Last. Madhuri KadiyalaH-Index: 2
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Significance Curcumin, rutin and quercetin are well-known flavonoids & piperine is an alkaloid, commonly used as spices and traditionally used to treat a variety of conditions. In the current scenario, the stability problems of phytoconstituents are a major problem for regulators and because of the complex nature of the components of plant extracts. Objective A simple, fast and sensitive ultra-force reverse phase liquid chromatography (RP-UFLC) has been developed, validated and studied for degra...
In the mid-end of December 2019, several cases of pneumonia outbreak of unknown cause and etiology were identified in Wuhan City of Hubei province in China, a city with a population of over 11 million Till date(April 2020) around 1,051,635 confirmed cases of coronavirus disease 2019(COVID-19) and 56,985 confirmed deaths have been reported according to COVID-19 Situation Report � 75 by WHO On 7th January 2020, the causative agent was iden-tified and named consequently as Severe Acute Respiratory ...
#1Rajan Kumar (LPU: Lovely Professional University)H-Index: 5
#2Rubiya Khursheed (LPU: Lovely Professional University)H-Index: 9
Last. Ashish WadhwaniH-Index: 10
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Abstract Fisetin is a plant derived flavonoid that possesses anti-cancer, anti-oxidant and anti-Parkinson's activities. However, due to its lipophilicity it suffers from dissolution rate limited oral bioavailability that reduces its therapeutic efficacy. In order to overcome this issue self-nanoemulsifying drug delivery system (SNEDDS) of fisetin were formulated and characterized for droplet size, shape, zeta potential, cell viability, dissolution and permeability studies. Prepared SNEDDS (1.2 m...
14 CitationsSource
#1Parth Sharma (LPU: Lovely Professional University)H-Index: 4
#2Sachin Kumar Singh (LPU: Lovely Professional University)H-Index: 19
Last. Rubiya Khursheed (LPU: Lovely Professional University)H-Index: 9
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Abstract In the present study, different solid self-nanoemulsifying drug delivery system (S-SNEDDS) was formulated by using porous hydrophilic and hydrophobic carriers to improve the dissolution rate and bioavailability of simvastatin (SIM). The prepared liquid-SNEDDS composed of Labrafil M 1944 CS/ Tween-80/ Ethanol (20% / 53.33%/26.67% v/v) with 0.1% SIM, resulted droplet size of 40.69 nm. The hydrophobic carriers used were Aerosil-200, Syloid 244FP, Syloid XDP 3150, Magnesium stearate, Micro ...
9 CitationsSource
#1Abhishek SoniH-Index: 1
#2K. Gowthamarajan (Jagadguru Sri Shivarathreeswara University)H-Index: 17
Last. Arun RadhakrishnanH-Index: 6
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Over the past few decades, the concept of personalized medicine has proved to play an important role in the healthcare sector. Personalized medicine modifies the current dosage forms according to the needs of the patient. Based on this improved concept, we are now able to bring out best treatment options for a particular individual leading to better therapeutic outcomes and decreased adverse effects. It also has the potential to identify the disease at an earlier stage. It links the diseased con...
2 Citations
AbstractNanotechnology based biomedical approaches and surface modification techniques made it easier for targeting specific site and improving the treatment efficacy. The present study reports on targeted polymeric nanoparticles conjugated with antibody as a site-specific carrier system for effective treatment of type 1 diabetes. Sitagliptin (SP)-loaded Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NP) were prepared by nanoprecipitation cum solvent evaporation method and were characteriz...
4 CitationsSource
#1Sarvi Yadav Rajesh (LPU: Lovely Professional University)H-Index: 4
#2Sachin Kumar Singh (LPU: Lovely Professional University)H-Index: 19
Last. Saurabh Singh (LPU: Lovely Professional University)H-Index: 6
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AbstractDevelopment of self-nanoemulsifying drug delivery systems (SNEDDS) of glimepiride is reported with the aim to achieve its oral delivery. Lauroglycol FCC, Tween-80, and ethanol were used as oil, surfactant, and co-surfactant, respectively as independent variables. The optimized composition of SNEDDS formulation (F1) was 10% v/v Lauroglycol FCC, 45% v/v Tween 80, 45% v/v ethanol, and 0.005% w/v glimepiride. Further, the optimized liquid SNEDDS were solidified through spray drying using var...
13 CitationsSource