Orazio Fortunato
University of Milan
CancerInternal medicineCXCR4OncologymicroRNACellChemistryCell typeImmunologyMicrovesiclesTumor microenvironmentMdm2Lung cancerLung cancer screeningCisplatinMetastasisRhabdomyosarcomaCancer researchCarcinogenesisBioinformaticsCell growthMedicineIn situ hybridizationA549 cellBiologyImmune systemCancer cell
Publications 31
#1Daniela Di Paolo (Istituto Giannina Gaslini)H-Index: 22
Last. Cristina BorziH-Index: 8
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Lung cancer is the leading cause of cancer-related death worldwide. Late diagnosis and metastatic dissemination contribute to its low survival rate. Since microRNA (miRNA) deregulation triggers lung carcinogenesis, miRNAs might represent an interesting therapeutic tool for lung cancer management. We identified seven miRNAs, including miR-126-3p and miR-221-3p, that are deregulated in tumours compared with normal tissues in a series of 38 non-small-cell lung cancer patients. A negative correlatio...
#1Giulia BertoliniH-Index: 13
#2Valeria Cancila (University of Palermo)H-Index: 10
Last. Luca RozH-Index: 31
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Abstract Platinum-based chemotherapy remains widely used in advanced non-small cell lung cancer (NSCLC) despite experimental evidence of its potential to induce long-term detrimental effects, including the promotion of pro-metastatic microenvironments. Here, we investigated the interconnected pathways underlying the promotion of cisplatin-induced metastases. In tumor-free mice, cisplatin treatment resulted in an expansion in the bone-marrow of CCR2+CXCR4+Ly6Chigh inflammatory monocytes (IM) and ...
Background Rhabdomyosarcoma (RMS), the most frequent soft-tissue sarcoma in childhood, shows extensive heterogeneity in histology, site and age of onset, clinical course, and prognosis. Adolescents and young adults (AYA) with RMS form a subgroup of patients whose survival lacks behind that of children while diagnosed with histologically similar tumors. Procedures A 67-gene prognostic signature related to chromosome integrity, mitotic control, and genome complexity in sarcomas (CINSARC) is consid...
#1Gabriella SozziH-Index: 71
#1Gabriella SozziH-Index: 2
Last. Licia RivoltiniH-Index: 88
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#1Fabio MaiullariH-Index: 4
#2Maila Chirivì (National Research Council)H-Index: 3
Last. Roberto Rizzi (National Research Council)H-Index: 27
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Extracellular vesicles (EVs) have become a key tool in the biotechnological landscape due to their well-documented ability of mediating intercellular communication. Such feature has been explored and, actually, it is under constant investigation by researchers, who have unraveled the important role of EVs in several research fields ranging from oncology, immunology and diagnostics to regenerative medicine. Unfortunately, there are still some limits to overcome before a clinical application, incl...
2 CitationsSource
#1Giulia BertoliniH-Index: 13
#2Valeria CancilaH-Index: 10
Last. Luca RozH-Index: 1
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Abstract Platinum-based chemotherapy remains widely used in advanced non-small cell lung cancer (NSCLC) despite its ineffectiveness in long-term control of metastasis. Here, we uncover the interconnected pathways subtending cisplatin-induced metastasis promotion. We report that cisplatin treatment of tumor-free mice results in bone-marrow expansion of CCR2+CXCR4+Ly6Chigh inflammatory monocytes (IM) concomitantly with increased levels in the lungs of stromal SDF-1, the CXCR4 ligand. In experiment...
#1Orazio FortunatoH-Index: 11
Last. Giulia BertoliniH-Index: 13
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Cancer stem cells (CSCs) are functionally defined as the cell subset with greater potential to initiate and propagate tumors. Within the heterogeneous population of lung CSCs, we previously identified highly disseminating CD133+CXCR4+ cells able to initiate distant metastasis (metastasis initiating cells-MICs) and to resist conventional chemotherapy. The establishment of an immunosuppressive microenvironment by tumor cells is crucial to sustain and foster metastasis formation, and CSCs deeply in...
#1Matteo Gallazzi (University of Insubria)H-Index: 5
#2Orazio FortunatoH-Index: 11
Last. Antonino BrunoH-Index: 21
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Lung cancer is the leading cause of cancer-related death worldwide and the only curative treatment remains surgery. Recurrence rates in resected patients remain high: from 30% for stage I to 80% for stage III. We previously demonstrated the role of 24 microRNAs in the pathogenesis and aggressiveness of lung tumors. Natural Killer (NK) cells, cellular mediators involved in tumor immunosurveillance are functionally compromised in cancer patients. We discovered that tumor infiltrating NK cells (TIN...