Yiping Dong
Xi'an Jiaotong University
Cell cycle checkpointLoss functionObstetrics and gynaecologyCytotoxicityGene silencingCancerNuclear receptor coactivator 2Internal medicineDownregulation and upregulationFunction (biology)PathologyDNA damageKEGGDrugBankAutoantibodyRegulation of gene expressionGene knockdownSmall nucleolar RNAKinaseChemistryApoptosisKu80Protein kinase CIn vitroImmunohistochemistrySPOPProstateRadiosensitizerNeuroblastomaGallbladderCirrhosisHeLaCarcinomaAspirinSinomenineAlkaloidHepatocellular carcinomaTumor initiationRAD51MetastasisMalignancyEsophageal cancerTetrandrineTRIM24Prostate cancerMTT assayOncogeneTargeted therapyRecurrent Hepatocellular CarcinomaGMP biosynthetic processCell cycleBioinformatics analysisFuture studiesNon small cellMolecular mechanismProliferating cell nuclear antigenSerologyMutationCancer researchColorectal cancerBreast cancerG2-M DNA damage checkpointFlow cytometryCancer stem cellCarcinogenesisMAPK/ERK pathwayReceiver operating characteristicCompeting endogenous RNACell growthLong non-coding RNASignal transductionMolecular medicineRNAMedicineBiomarker (medicine)CoactivatorBlotPI3K/AKT/mTOR pathwayBiologyMechanism (biology)GastroenterologyCell biology
13Publications
6H-index
77Citations
Publications 10
Newest
#1Minghua Bai (Xi'an Jiaotong University)H-Index: 1
#2Chenchen He (Xi'an Jiaotong University)H-Index: 8
Last. Suxia Han (Xi'an Jiaotong University)H-Index: 18
view all 9 authors...
Previous studies have shown that both long intergenic non-coding RNA 00963 (Linc00963) and tripartite motif containing 24 (TRIM24) are activators of the PI3K/AKT pathway, and both are involved in the carcinogenesis and progression of prostate cancer. However, the regulatory mechanisms between Linc00963 and TRIM24 are still unclear. In this study, we aimed to elucidate the underlying relationship between Linc00963 and TRIM24 in castration-resistant prostate cancer (CRPC). We found that TRIM24, an...
Source
#1Minghua Bai (Xi'an Jiaotong University)H-Index: 1
#2Yutiantian Lei (Xi'an Jiaotong University)H-Index: 4
Last. Suxia Han (Xi'an Jiaotong University)H-Index: 18
view all 8 authors...
Previously, we found that the expression of long non-coding RNA (LncRNA) small nucleolar RNA host gene 17 (SNHG17) was up-regulated in castration-resistant prostate cancer (CRPC) cells compared to that in hormone sensitive prostate cancer (HSPC) cells. Moreover, we also found that CD51 was up-regulated in prostate cancer cells, and promoted the carcinogenesis and progression of prostate cancer. However, the regulatory mechanism of SNHG17 and CD51 in the development of CRPC remains unclear. In th...
4 CitationsSource
#1Minghua Bai (Xi'an Jiaotong University)H-Index: 1
#2Yiping Dong (Xi'an Jiaotong University)H-Index: 6
Last. Suxia Han (Xi'an Jiaotong University)H-Index: 18
view all 6 authors...
Esophageal cancer has recent shown a higher incidence but lower 5-year survival rate after normal clinical treatment in China. The aim of this study was to observe whether the inhibition of miR-196a affects esophageal cancer cell growth by modulating the nuclear factor-kappaB target gene and to detect the possible cooperative therapeutic effects on esophageal cancer by knocking down miR-196a expression combined with the specific inhibitor of nuclear factor-kappaB target genes. Thus, anti-miR-196...
1 CitationsSource
#1Xi Jia (Xi'an Jiaotong University)H-Index: 1
#2Qian Zhao (Xi'an Jiaotong University)H-Index: 1
Last. Jinsong Hu (Xi'an Jiaotong University)H-Index: 13
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Abstract Thyroid cancer (TC) ranks as the most common endocrine malignancy, and its incidence and mortality rates continue to rise annually. Increasing evidence have shown that DNA methylation, a k...
1 CitationsSource
#1Qian Zhao (Xi'an Jiaotong University)H-Index: 2
#2Xi Jia (Xi'an Jiaotong University)H-Index: 1
Last. Jinlu Ma (Xi'an Jiaotong University)H-Index: 9
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Abstract Tetrandrine (TET), a bis-benzylisoquinoline alkaloid, shows cytotoxicity against several different types of tumors. However, the mechanism by which TET exerts its anti-cancer capabilities remains unclear. In this study, we confirmed that TET inhibits proliferation and induces apoptosis in neuroblastoma (NB) in vitro and in vivo. Moreover, we revealed that the anti-cancer ability of TET is associated with a decreased expression of anti-apoptotic Bcl-2. Importantly, we demonstrated that t...
6 CitationsSource
#1Mengjiao Cai (Xi'an Jiaotong University)H-Index: 4
#2Xin Liang (Protein Sciences)H-Index: 1
Last. Suxia Han (Xi'an Jiaotong University)H-Index: 18
view all 8 authors...
As a member of the p160 steroid receptor coactivator (SRC) gene family, nuclear receptor coactivator 2 (NCOA2) is known to play essential roles in many physiological and pathological processes, including development, endocrine regulation and tumorigenesis. However, the biological functions of NCOA2 in breast cancer is not fully understood. We found that the copy number of NCOA2 gene was frequently amplified in four breast cancers datasets, varying from 6% to 10%, and the mRNA levels of NCOA2 wer...
7 CitationsSource
#1Liuyun Gong (Xi'an Jiaotong University)H-Index: 3
#2Yutiantian Lei (Xi'an Jiaotong University)H-Index: 4
Last. Suxia Han (Xi'an Jiaotong University)H-Index: 18
view all 7 authors...
Abstract Aim To observe the effect of propranolol in cervical cancer and investigate the mechanism of the effect. Methods and Results We found 5 direct protein targets (DPTs) of propranolol (PRO) by DrugBank5.0 firstly. Next, we analyzed protein-protein interaction (PPI) network and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of PRO DPTs and the result showed that PRO was linked with cGMP/PKG pathway. Then, we recognized the top 38 upexpressed genes of cervical cancer (CC) based orig...
5 CitationsSource
#1Yiping Dong (Xi'an Jiaotong University)H-Index: 6
#2Dan Zhang (Xi'an Jiaotong University)H-Index: 3
Last. Suxia Han (Xi'an Jiaotong University)H-Index: 18
view all 10 authors...
Speckle-type POZ protein (SPOP) plays an important role in maintaining genome stability. Disability or mutation of the SPOP gene has been reported to contribute to prostate cancer incidence and prognosis. However, the functions of SPOP in lung cancer remain poorly understood, especially in lung adenocarcinoma (LUAD). Here, we found that SPOP affects the LUAD cell response to radiation by regulating the DNA damage response (DDR) pathway. SPOP is widely expressed in lung cancer cell lines, and SPO...
7 Citations
#1Liuyun Gong (Xi'an Jiaotong University)H-Index: 3
#2Dan Zhang (Xi'an Jiaotong University)H-Index: 8
Last. Jiquan Wang (Xi'an Jiaotong University)H-Index: 1
view all 8 authors...
Abstract Purpose We explored the mechanism of aspirin in SCLC by dissecting many publicly available databases. Methods and results Firstly, 11 direct protein targets (DPTs) of aspirin were identified by DrugBank 5.0. Then protein–protein interaction (PPI) network and signaling pathways of aspirin DPTs were analyzed. We found that aspirin was linked with many kinds of cancer, and the most significant one is SCLC. Next, we classified the mutation of 4 aspirin DPTs in SCLC ( IKBKB , NFKBIA , PTGS2 ...
2 CitationsSource
#1Cong‐ya Zhou (Sichuan University)H-Index: 1
#2Yiping Dong (Xi'an Jiaotong University)H-Index: 6
Last. Suxia Han (Xi'an Jiaotong University)H-Index: 18
view all 10 authors...
Carbohydrate antigen 19‐9 (CA19‐9) fails to demonstrate the predictive value for early detection pancreatic ductal adenocarcinoma (PDAC). Glypican‐1 (GPC1+) exosomes may serve as a noninvasive diagnostic tool to detect early stages of PDAC. Therefore, it is necessary to explore the serum GPC1 levels and determine whether serum GPC1 serves as a novel biomarker for PDAC patients. Blood samples were collected from 156 patients with PDAC, 199 non‐cancer controls, and 240 patients with other cancers....
14 CitationsSource