Xiaoli Wang
International Institute of Minnesota
Cardiac function curveInternal medicineEndocrinologyPathologySteatosisNonalcoholic fatty liver diseaseType 2 diabetesInsulin resistanceDyslipidemiaInsulinSteatohepatitisProteinuriaDiabetic nephropathyFibrosisMetabolic syndromeNephropathyType 2 Diabetes MellitusStreptozocinLiver functionGlucose homeostasisPhysiologyObesityDiabetes mellitusMedicineEjection fraction
17Publications
5H-index
53Citations
Publications 17
Newest
#1Kamal Albarazanji (Janssen Pharmaceutica)H-Index: 2
#2Andrea Nawrocki (Janssen Pharmaceutica)
Last. Yong-Fu XiaoH-Index: 4
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Meal ingestion elicits a variety of neuronal, physiological and hormonal responses that differ in healthy, obese or diabetic individuals. The mixed meal tolerance test (MMTT) is a well-established method to evaluate pancreatic β-cell reserve and glucose homeostasis in both preclinical and clinical research in response to calorically defined meal. Nonhuman primates (NHPs) are highly valuable for diabetic research as they can naturally develop type 2 diabetes mellitus (T2DM) in a way similar to th...
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#1Jiajun GaoH-Index: 1
#2Xiaoli WangH-Index: 5
Last. Yong-Fu XiaoH-Index: 4
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ong-term hyperglycemia can impair renal microvessels and lead to diabetic nephropathy (DN). Early treatment can delay or prevent its progression. Efficacy of monoclonal antibody (mAb) therapies for human diseases can often be tested only in nonhuman primates (NHPs) but no other species due to lack of human mAb cross-reactivity. To test if DN in NHPs is similar to the human disease, this study analyzed the blood and urine biochemistry data from a large pool (n=129) of cynomolgus monkeys (Macacafa...
#1Guodong ZhangH-Index: 1
#2Xiaoli WangH-Index: 5
Last. Yixin Jim WangH-Index: 3
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Multiple murine models of nonalcoholic fatty liver disease/steatohepatitis (NAFLD/NASH) have been established by using obesogenic diets and/or chemical induction. MS-NASH mouse (formally FATZO) is a spontaneously developed dysmetabolic strain that can progress from hepatosteatosis to moderate fibrosis when fed a western diet supplemented with 5% fructose (WDF). This study aimed to use carbon tetrachloride (CCl4) to accelerate and aggravate progression of NAFLD/NASH in MS-NASH mouse. Male MS-NASH...
1 CitationsSource
#1Jiajun GaoH-Index: 1
Last. Yong-Fu XiaoH-Index: 4
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Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome as an arising health issue globally. Obesity and diabetes seem coherent with high NAFLD occurrence. Currently, its underlying mechanism of cause and progression remains to be elicited and effective therapy is unavailable. Huge investment on studying its pathogenesis and innovative therapy is underway. As mechanistic studies are more difficult or unethical to be performed in humans, animal model that recap...
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#1Xiaoli WangH-Index: 5
Last. Yong-Fu XiaoH-Index: 4
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The FATZO mouse is a polygenic model with an intact leptin system and was developed by cross breeding of C57BL6/J (C57) with AKR/J. FATZO mice have been used in many dysmetabolic studies. The epidemic health issue of nonalcoholic fatty liver disease (NAFLD, including NASH) is the organ dysmetabolic manifestation. This study was to investigate a high fat/fructose diet (HFFD) on liver function in FATZO mice. The body weights of FATZO (n=30) at age of 9 to 10 weeks were significantly heavier than t...
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#1Yongqiang LiuH-Index: 3
#2Jiajun GaoH-Index: 1
Last. Yong-Fu XiaoH-Index: 4
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Streptozocin (STZ), a naturally occurring glucosamine-nitrosourea compound, has been used for diabetogenic induction in animals for diabetic research due to its high toxicity to pancreatic beta cells. This study was to evaluate the diabetogenic effects of STZ by multiple low doses or by single high dose in normoglycemic Non-Human Primates (NHPs). Each monkey in the 1st group (n=6) was intravenously administered with 7.5 to 15 mg/kg STZ once every 2 to 4 weeks until successful induction of hyperg...
1 CitationsSource
#1Yixin WangH-Index: 4
#2Yongqiang LiuH-Index: 3
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Pancreatic β-cell regeneration is considered as a possible therapy for cure of type 2 diabetes (T2D). It has been reported that administration of FTY720, a sphingosine 1-phosphate (S1P) receptor modulator, to db /db mice led to sustained normalization of hyperglycemia by stimulating β-cell in vivo regeneration through PI3K-dependent regulation of cyclin D3 and p57 KIP2 . To further evaluate the therapeutic potential of FTY720 in the treatment of T2D, we examined the effects of FTY720 on glucose ...
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#1Bingdi WangH-Index: 5
#2Wei QiaoH-Index: 1
Last. Yong-Fu XiaoH-Index: 4
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Timely knowing glucose level helps diabetic patients to manage the disease, including decisions about food, physical activity and medication. This study compared two continuous glucose monitoring systems in conscious and moving-free nonhuman primates (NHPs, Macaca fascicularis). Each normoglycemic or diabetic monkey was implanted with one Dexcom G4 Platinum subcutaneously or one HD-XG glucose sensor arterially for glucose monitoring. The glucose levels measured by both telemetry devices signific...
1 CitationsSource
#1Yongqiang LiuH-Index: 3
#2Haihua GuH-Index: 2
Last. Yi Xin Jim WangH-Index: 1
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Purpose: Patients with obesity and type 2 diabetes (T2D) are more susceptible to the occurrence of nonalcoholic fatty liver disease (NAFLD)/steatohepatitis (NASH). Although liver biopsy is still reviewed as a gold standard for the diagnosis, due to its invasiveness, high cost and variable readouts, it has limited application in large scale clinical investigation and long term following up the therapeutic benefits. This study was to apply a clinically used noninvasive echography to quantitatively...
2 CitationsSource
#1Yongqiang LiuH-Index: 3
#2Xiaoli WangH-Index: 5
Last. Yong-Fu XiaoH-Index: 4
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Effects of betatrophin on β-cell proliferation and insulin secretion have been reported controversially in rodent studies. This study was to investigate the dynamic changes of betatrophin and its potential effect on β-cell function in non-human primates (NHPs). Blood betatrophin levels in naturally developed diabetes cynomolgus monkeys (n=65) significantly correlated with their body weights and blood glucose levels in the females (n=20) and with insulin and C-peptide levels in the males (n=45). ...
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