Yong Yang
Chinese Academy of Sciences
EctodomainSerotypeCell cycle checkpointEpidemiologyGene silencingGenotypeNeutralizationmicroRNAAntigenCellular differentiationMolecular biologyVirologyAntibodyLibrary scienceApoptosisChinaPhylogenetic treeEpitopeAntibody-dependent enhancementImmunologyVaccinationVirusSurvivinPathogenAdenoviridaeEnterovirusSeroprevalenceEnterovirus 71Foot-and-mouth diseaseCoxsackievirusNeutralizing antibodyHeterologousInfluenza vaccineImmunizationImmunogenicitySpike (database)Novel virusPopulationViral VaccineCreative commonsThird partyChinese academy of sciencesSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Antibody responseVeterinary medicineCancer researchChristian ministryViral entryMedicineBiologyPandemicMitosisCancer cell
8Publications
7H-index
126Citations
Publications 8
Newest
#1Jinkai Zang (CAS: Chinese Academy of Sciences)H-Index: 3
#2Yuanfei Zhu (Fudan University)H-Index: 8
Last. Yannan Yin (CAS: Chinese Academy of Sciences)
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Massive production of efficacious SARS-CoV-2 vaccines is essential for controlling the ongoing COVID-19 pandemic. We report here the preclinical development of yeast-produced receptor-binding domain (RBD)-based recombinant protein SARS-CoV-2 vaccines. We found that monomeric RBD of SARS-CoV-2 could be efficiently produced as a secreted protein from transformed Pichia pastoris (P. pastoris) yeast. Yeast-derived RBD-monomer possessed functional conformation and was able to elicit protective level ...
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#1Jinkai Zang (CAS: Chinese Academy of Sciences)H-Index: 3
#2Chenjian Gu (Fudan University)H-Index: 4
Last. Zhong Huang (CAS: Chinese Academy of Sciences)H-Index: 29
view all 15 authors...
Zhou, P. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579, 270–273 (2020). CAS Article Google Scholar Amanat, F. & Krammer, F. SARS-CoV-2 vaccines: status report. Immunity 52, 583–589 (2020). CAS Article Google Scholar Chen, W. H., Strych, U., Hotez, P. J. & Bottazzi, M. E. The SARS-CoV-2 vaccine pipeline: an overview. Curr. Trop. Med. Rep. 7, 61–64 (2020). Article Google Scholar Hotez, P. J., Corry, D. B. & Bottazzi, M. E. COVID-19 vaccine design:...
25 CitationsSource
#1Jinkai Zang (CAS: Chinese Academy of Sciences)H-Index: 3
#2Chenjian Gu (Fudan University)H-Index: 5
Last. Zhong Huang (CAS: Chinese Academy of Sciences)H-Index: 29
view all 19 authors...
Recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic. Currently, there is no vaccine available for preventing SARS-CoV-2 infection. Like closely related severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV-2 also uses its receptor-binding domain (RBD) on the spike (S) protein to engage the host receptor, human angiotensin-converting enzyme 2 (ACE2), facilitating subsequ...
11 CitationsSource
#1Xinying Tang (CAS: Chinese Academy of Sciences)H-Index: 8
#2Yong Yang (CAS: Chinese Academy of Sciences)H-Index: 7
Last. Dongming Zhou (CAS: Chinese Academy of Sciences)H-Index: 21
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: Influenza is a zoonotic disease that poses severe threats to public health and the global economy. Reemerging influenza pandemics highlight the demand for universal influenza vaccines. We developed a novel virus platform using extracellular domain IV of the matrix 2 protein (M2e), AdC68-F3M2e, by introducing three conserved M2e epitopes into the HI loop of the chimpanzee adenovirus (AdV) fiber protein. The M2e epitopes were expressed sufficiently on the AdV virion surface without affecting fib...
9 CitationsSource
#1Chao Zhang (CAS: Chinese Academy of Sciences)H-Index: 123
#2Yong Yang (CAS: Chinese Academy of Sciences)H-Index: 7
Last. Dongming Zhou (CAS: Chinese Academy of Sciences)H-Index: 21
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Hand, foot and mouth disease (HFMD) is a major public health concern in Asia; more efficient vaccines against HFMD are urgently required. Adenoviral (Ad) capsids have been used widely for the presentation of foreign antigens to induce specific immune responses in the host. Here, we describe a novel bivalent vaccine for HFMD based on the hexon-modified, E1-deleted chimpanzee adenovirus serotype 68 (AdC68). The novel vaccine candidate was generated by incorporating the neutralising epitope of Coxs...
11 CitationsSource
#1Chao Zhang (CAS: Chinese Academy of Sciences)H-Index: 123
#2Rui Zhu (CAS: Chinese Academy of Sciences)H-Index: 1
Last. Dongming Zhou (CAS: Chinese Academy of Sciences)H-Index: 21
view all 10 authors...
Hand, foot and mouth disease (HFMD) is a serious public health problem that has emerged over the past several decades. Pathogen detection by the Chinese national HFMD surveillance system has focused mainly on enterovirus 71 (EV71) and coxsackievirus A16 (CA16). Therefore, epidemiological information regarding the other causative enteroviruses is limited. To identify the pandemic enterovirus in Suzhou, Jiangsu province, China, clinical samples from patients with HFMD were collected from 2012 to 2...
30 CitationsSource
#1Xiang Wang (CAS: Chinese Academy of Sciences)H-Index: 14
#1Xiang Wang (CAS: Chinese Academy of Sciences)H-Index: 4
Last. Dongming Zhou (CAS: Chinese Academy of Sciences)H-Index: 21
view all 10 authors...
Hand, foot and mouth disease (HFMD) is an important public health problem that has emerged over the past several years. HFMD predominantly infects children under seven years old and occasionally causes severe disease in adults. Among the enteroviruses, enterovirus 71 (EV71) and coxsackievirus 16 (CA16) are the major causative agents of HFMD. In addition, adenovirus cocirculates with enterovirus and has become a possible additional pathogenic factor for HFMD in some cases. Here, we have investiga...
30 CitationsSource
#1Yudan Chi (CAS: Chinese Academy of Sciences)H-Index: 6
#2Xiang Wang (CAS: Chinese Academy of Sciences)H-Index: 14
Last. Dongming Zhou (CAS: Chinese Academy of Sciences)H-Index: 21
view all 6 authors...
Survivin is highly expressed in most human tumors and fetal tissue, and absent in terminally differentiated cells. It promotes tumor cell proliferation by negatively regulating cell apoptosis and facilitating cell division. Survivin's selective expression pattern suggests that it might be a suitable target for cancer therapy, which would promote death of transformed but not normal cells. This was tested using artificial microRNAs (amiRNAs) targeting survivin. After screening, two effective amiRN...
20 CitationsSource