Eleonora Scaccia
Sapienza University of Rome
AcetylationStromal cellAdipose tissueChemistryMesenchymal stem cellProgenitor cellOxidative stressHistone deacetylase inhibitorPlatelet lysateDental pulp stem cellsPeriodontitisAngiogenesisCell fate commitmentEpigeneticsTransdifferentiationHistoneMedicineChromatinNeuropeptide Y receptorCell biology
Publications 4
#1Eleonora Scaccia (Sapienza University of Rome)H-Index: 2
#2Antonella Bordin (Sapienza University of Rome)H-Index: 8
Last. Elena De Falco (Sapienza University of Rome)H-Index: 19
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Abstract Although controlling a wide range of physiological cell functions, redox states unbalance during inflammation toward oxidative stress. Specific regions of our genome are extremely sensitive to both oxygen and reactive oxygen species, therefore modulating gene transcription in response to this specific epigenetic effect. Additional epigenetic mechanisms may include the alteration of the methylation states of DNA, protein and lipid nitration or modulation of specific microRNAs. A crucial ...
#1Antonella Bordin (Sapienza University of Rome)H-Index: 8
#2Francesca Pagano (Sapienza University of Rome)H-Index: 13
Last. Elena De Falco (Sapienza University of Rome)H-Index: 19
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Type 2 diabetes (T2D) is a major metabolic disease and a key epigenetic risk factor for the development of additional clinical complications. Among them, periodontitis (PD), a severe inflammatory disease ascribable to a dysregulated physiology and composition of the oral microbiota, represents one of the most relevant complications. Periodontitis can impact the structure of the tooth and likely the stem and progenitor cell pool, which actively contributes to the periodontal microenvironment and ...
2 CitationsSource
#1Rita Businaro (Sapienza University of Rome)H-Index: 18
#2Eleonora Scaccia (Sapienza University of Rome)H-Index: 2
Last. Elena De Falco (Sapienza University of Rome)H-Index: 19
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Neuropeptide Y (NPY), a powerful neurotransmitter of the central nervous system, is a key regulator of angiogenesis and biology of adipose depots. Intriguingly, its peripheral vascular and angiogenic powerful activity is strictly associated to platelets, which are source of clinical hemoderivates, such as platelet lysate (PL), routinely employed in several clinical applications as wound healing, and to preserve ex vivo the progenitor properties of the adipose stromal cells pool. So far, the pres...
8 CitationsSource
#1Elena De Falco (Sapienza University of Rome)H-Index: 19
#2Antonella Bordin (Sapienza University of Rome)H-Index: 8
Last. Giacomo Frati (Sapienza University of Rome)H-Index: 47
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Abstract Background Although adipose stromal cells (ASCs) retain the ability to transdifferentiate at low rate towards the cardiac lineage, the potential mechanisms underlying such process have still to be elucidated. Methods Since chromatin state modifications are involved in several processes regulating the cellular cell fate commitment, we aimed at evaluating the role of histone protein acetylation in the cardiovascular-like transdifferentiation of ASCs. Results We found a clear increase of h...
2 CitationsSource
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