Xiao-Ying Chen
Guangzhou University of Chinese Medicine
PharmacokineticsProinflammatory cytokineTumor necrosis factor alphaChemistryImmunologyMyeloperoxidaseSuperoxide dismutaseOxidative stressOral administrationPogostemonNF-?BProstaglandin E2Bronchoalveolar lavageAntioxidantLipopolysaccharideGCLCPiperineLung injuryChromatographyGlutathioneBiochemistryMedicinePharmacology
13Publications
10H-index
286Citations
Publications 14
Newest
#1Xiao-Ying Chen (Guangzhou University of Chinese Medicine)H-Index: 10
#2Qingfeng XieH-Index: 9
Last. Jian-Hui Xie (Guangzhou University of Chinese Medicine)H-Index: 21
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Abstract null null Tetrahydrocurcumin (THC) is an essential metabolite of curcumin, a major active component of the Curcuma species, which have been used traditionally for the treatment of cardiovascular diseases. The PI3K/AKT/mTOR signaling pathways serve a vital role during myocardial ischemia-reperfusion (MI/R) injury. The aim of the present study was to investigate the cardioprotective potential and mechanism of THC. In the in vivo study, an animal model of MI/R was induced by coronary occlu...
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#1Xiao-Ying Chen (Guangzhou University of Chinese Medicine)H-Index: 10
#2Yao-Xing Dou (Guangzhou University of Chinese Medicine)H-Index: 9
Last. Yu-Cui Li (Guangzhou University of Chinese Medicine)H-Index: 20
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Abstract β-Patchoulene (β-PAE), a tricyclic sesquiterpene isolated from the essential oil of the leaves and stems of Pogostemon cablin ( Blanco ) Benth ., has been reported to have potent anti-inflammatory activity. The aim of this study was to evaluate the potential protective effect of β-PAE on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice and to illuminate the underlying mechanisms. ALI was induced by intracheal instillation of LPS into lung, and dexamethasone (DEX) was use...
22 CitationsSource
#1Zhen-Biao Zhang (Guangzhou University of Chinese Medicine)H-Index: 14
#2Xiao-Ying Chen (Guangzhou University of Chinese Medicine)H-Index: 10
Last. Zi-Ren Su (Guangzhou University of Chinese Medicine)H-Index: 30
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β-Patchoulene (β-PAE) is a tricyclic sesquiterpene isolated from the oil of Pogostemon cablin (patchouli oil), which has been widely used in traditional Chinese medicine for the treatment of inflammatory diseases. However, as one of the major principle of patchouli oil, the biological activity of β-PAE has not been explored so far. In the present study, the anti-inflammatory activity in vivo, and the underlying mechanism, of β-PAE was investigated on experimental mice models of acute inflammatio...
37 CitationsSource
#1Xiao-Ying ChenH-Index: 10
#2Guanghua YangH-Index: 4
Last. Ji LinH-Index: 1
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Purpose: To investigate the pharmacokinetic mechanism of interaction between magnolol and piperine when co-administered to rats. Methods: The rats were divided into five groups as follows: magnolol group (625 mg/kg); low dose of piperine group (20 mg/kg); high dose of piperine group (40 mg/kg); low dose of piperine + magnolol group; or high dose of piperine + magnolol group. Plasma samples were collected at regular time intervals after administration of a single dose of magnolol (625 mg/kg, p.o....
3 CitationsSource
#1Chao-Yue Sun (Guangzhou University of Chinese Medicine)H-Index: 12
#2Lie-Qiang Xu (Guangzhou University of Chinese Medicine)H-Index: 9
Last. Zi-Ren Su (Guangzhou University of Chinese Medicine)H-Index: 30
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Abstract Pogostone, a major component of Pogostemon cablin , has been demonstrated to possess antibacterial, anti-fungal, immunosuppressive and anti-inflammatory properties. To investigate the potential therapeutic effect of pogostone on lipopolysaccharide (LPS)-induced acute lung injury (ALI), mice were pretreated with pogostone prior to LPS exposure. After LPS challenge, the lungs were excised and the histological changes, wet to dry weight ratios, MPO activity reflecting neutrophil infiltrati...
34 CitationsSource
#1Zu-Qing Su (Guangzhou University of Chinese Medicine)H-Index: 14
#2Jin-Bin Liao (Guangzhou University of Chinese Medicine)H-Index: 6
Last. Yu-Cui Li (Guangzhou University of Chinese Medicine)H-Index: 20
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Patchouli alcohol (PA) is a tricyclic sesquiterpene isolated from Pogostemon cablin, which exerts anti-inflammatory, anti-influenza and cognitive-enhancing bioactivities. The present study aimed to investigate the protective effects of PA on acute lung injury (ALI) induced by intratracheal instillation of lipopolysaccharide (LPS) in mice. Dexamethasone was used as a positive drug for protection against LPS-induced ALI. The results of the present study demonstrated that pretreatment with PA signi...
13 CitationsSource
#1Xiao-Ying Chen (Guangzhou University of Chinese Medicine)H-Index: 10
#2Haiming Chen (Guangzhou University of Chinese Medicine)H-Index: 15
Last. Xiao-Qi Huang (Guangzhou University of Chinese Medicine)H-Index: 6
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Pogostemonis Herba, known as “Guang-Huo-Xiang” in Chinese, has been widely used in the treatment of gastrointestinal dysfunction. Pogostone is one of the major constituents of Pogostemonis Herba. The aim was to scientifically evaluate the possible gastroprotective effect and the underlying mechanisms of pogostone against indomethacin-induced gastric ulcer in rats. Rats were orally treated with vehicle, lansoprazole (30 mg/kg) or pogostone (10, 20 and 40 mg/kg) and subsequently exposed to acute g...
28 CitationsSource
#1Cailan Li (Guangzhou University of Chinese Medicine)H-Index: 12
#2Jian-Hui Xie (Guangzhou University of Chinese Medicine)H-Index: 21
Last. Xiaobo Yang (Guangzhou University of Chinese Medicine)H-Index: 4
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Rhizoma Coptidis, Cortex Phellodendri, and berberine were reported to inhibit Helicobacter pylori. However, the underlying mechanism remained elusive. Urease plays a vital role in H. pylori colonization and virulence. In this work, aqueous extracts of Rhizoma Coptidis, Cortex Phellodendri of different origins, and purified berberine were investigated against H. pylori urease and jack bean urease to elucidate the inhibitory capacity, kinetics, and mechanism. Results showed that berberine was the ...
21 CitationsSource
#1Yu-Hong Liu (Guangzhou University of Chinese Medicine)H-Index: 19
#2Zhen-Biao Zhang (Guangzhou University of Chinese Medicine)H-Index: 14
Last. Zi-Ren Su (Guangzhou University of Chinese Medicine)H-Index: 30
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Andrographolide sodium bisulfite (ASB), a water-soluble sulfonate of andrographolide has been shown to possess anti-inflammatory, antipyretic and analgesic activities. However, there is no report on the gastroprotective effect of ASB against indomethacin-induced gastric ulcer. Here we investigated the possible anti-ulcerogenic potential of ASB and the underlying mechanism against indomethacin-induced gastric ulcer in rats. The ulcer area, histopathological assessment, contents of gastric mucosal...
31 CitationsSource
Purpose : To develop and validate a rapid, sensitive and reliable ultra-fast liquid chromatography (UFLC) method with photodiode array (PDA) detection for the determination of pogostone (PO) in rat tissues using honokiol as internal standard (IS). Methods : Rats were randomly divided into two groups (intravenous administration group and oral administration group) and given of a single dose of 10 mg/kg PO by intravenous administration and oral administration, respectively. After intravenous injec...
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