Hao Chen
Southern Medical University
EpidemiologyCancerInternal medicineRadiologySurgeryOncologyRetrospective cohort studyStage (cooking)ChemistrySericinChemotherapyTNM staging systemLaparoscopyGastrectomyPostoperative complicationNomogramMultivariate analysisCancer researchProportional hazards modelColorectal cancerMedicineCohort
Publications 46
#1Yanrui Liang (Southern Medical University)H-Index: 2
#2Liying Zhao (Southern Medical University)H-Index: 17
Last. Guoxin Li (Southern Medical University)H-Index: 33
view all 10 authors...
BACKGROUND The benefits of adjuvant chemotherapy for elderly patients with gastric cancer (GC) remain unknown because elderly patients are underrepresented in most clinical trials. This study aimed to evaluate the effectiveness and complications of adjuvant chemotherapy in patients > 65 years of age after laparoscopic D2 gastrectomy. METHODS This was a single-center retrospective cohort study of elderly patients (> 65 years) with stage II/III GC who underwent curative laparoscopic D2 gastrectomy...
#1Yuming Jiang (Stanford University)H-Index: 15
#2Xiaokun Liang (CAS: Chinese Academy of Sciences)H-Index: 7
Last. Yaoqin Xie (CAS: Chinese Academy of Sciences)H-Index: 24
view all 14 authors...
Importance Occult peritoneal metastasis frequently occurs in patients with advanced gastric cancer and is poorly diagnosed with currently available tools. Because the presence of peritoneal metastasis precludes the possibility of curative surgery, there is an unmet need for a noninvasive approach to reliably identify patients with occult peritoneal metastasis. Objective To assess the use of a deep learning model for predicting occult peritoneal metastasis based on preoperative computed tomograph...
3 CitationsSource
#1Chen Xinhua (Southern Medical University)H-Index: 4
#2Yu Zhu (Southern Medical University)H-Index: 4
Last. Guoxin Li (Southern Medical University)H-Index: 33
view all 11 authors...
Background: The enhanced recovery after surgery (ERAS) programme is feasible and effective in reducing the length of hospital stay, overall complication rates and medical costs when applied to cases involving colonic and rectal resections. However, a recent prospective, randomised, open, parallel-controlled trial (Chinese Laparoscopic Gastrointestinal Surgery Study-01 trial), initiated by our team, indicated that under conventional peri-operative management, the reduction of the post-operative h...
1 CitationsSource
#1Zhian Chen (Southern Medical University)H-Index: 2
#2Yanrui Liang (Southern Medical University)H-Index: 2
Last. Yanfeng Hu (Southern Medical University)H-Index: 22
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Among various methods, the use of targeting nucleic acid therapy is a promising method for inhibiting gastric cancer (GC) cells' rapid growth and metastasis abilities. In this study, vitamin B12-labeled poly (d,l-lactide-co-glycolide) and polyethylene glycol nanoparticles (PLGA-PEG-VB12 NPs) were developed for microRNAs-532-3p mimics incorporating as targeting gene delivery systems (miR-532-3p@PLGA-PEG-VB12 NPs) to fight against transcobalamin II (CD320)-overexpressed GC cells' progression. The ...
#1Chen XinhuaH-Index: 4
#3Chen YuehongH-Index: 3
Last. Jiang YuH-Index: 27
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Objective This study aimed to determine the impact of type 2 diabetes mellitus (T2DM) on clinical outcomes of gastric cancer (GC) patients and explore whether metformin use and good glycemic control could reverse it. Methods Clinicopathologic data of consecutive GC patients who underwent gastrectomy at Nanfang Hospital between October 2004 and December 2015 were included. Propensity score matching (PSM) was performed to balance the important factors of the disease status between non-T2DM and T2D...
INTRODUCTION Treatments for young patients with gastric cancer (GC) remain poorly defined, and their effects on survival are uncertain. We aimed to investigate the receipt of chemotherapy by age category (18-49, 50-64, and 65-85 years) and explore whether age differences in chemotherapy matched survival gains in patients with GC. METHODS Patients who were histologically diagnosed with GC were included from a Chinese multi-institutional database and the Surveillance, Epidemiology, and End Results...
#1Zepang Sun (Southern Medical University)H-Index: 5
#2Hao Chen (Southern Medical University)H-Index: 12
Last. Guoxin Li (Southern Medical University)H-Index: 33
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Purpose Gastric cancer (GC) is a product of multiple genetic abnormalities, including genetic and epigenetic modifications. This study aimed to integrate various biomolecules, such as miRNAs, mRNA, and DNA methylation, into a genome-wide network and develop a nomogram for predicting the overall survival (OS) of GC. Materials and Methods A total of 329 GC cases, as a training cohort with a random of 150 examples included as a validation cohort, were screened from The Cancer Genome Atlas database....
#1Gengtai Ye (Southern Medical University)H-Index: 7
#2Qingbin Yang (Southern Medical University)H-Index: 3
Last. Guoxin Li (Southern Medical University)H-Index: 33
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Rationale: Peritoneal metastasis predicts poor prognosis of gastric cancer (GC) patients, and the underlying mechanisms are poorly understood. Methods: The 2-DIGE, MALDI-TOF/TOF MS and single-cell transcriptome were used to detect differentially expressed proteins among normal gastric mucosa, primary GC and peritoneal metastatic tissues. Lentiviruses carrying shRNA and transcription activator-like effector nuclease technology were used to knock down myosin heavy chain 9 (MYH9) expression in GC c...
4 CitationsSource
#1Chen Xinhua (Southern Medical University)H-Index: 4
#2Yanfeng Hu (Southern Medical University)H-Index: 22
Last. Jiang Yu (Southern Medical University)H-Index: 27
view all 9 authors...
Background Intracorporeal esophagojejunostomy via a transorally inserted-anvil method during laparoscopic total gastrectomy (LTG) for upper gastric cancer has been demonstrated to be feasible, but the use of this assessment exclusively for Siewert type 2 adenocarcinoma of the esophagogastric junction (AEG) has not been reported. Methods A total of 428 consecutive gastric-cancer patients who underwent LTG in Nanfang Hospital from January 2008 to December 2016 were reviewed. Among these patients, ...
3 CitationsSource
#1Li Zhen (Southern Medical University)H-Index: 8
#2Tian Lin (Southern Medical University)H-Index: 12
Last. Guoxin Li (Southern Medical University)H-Index: 33
view all 11 authors...
Acute abdomen, abdominal trauma, gastrointestinal bleeding and gastrointestinal tumors are the main conditions that are routinely treated in gastrointestinal surgery department with high incidence and critical condition. These conditions need emergency or selective operations. During the outbreak of the coronavirus disease 2019 (COVID-19), it's a great challenge for us to meet the patients' requirement under the situation. As the COVID-19 was brought under control in China, the Department of Gen...
5 CitationsSource