Jennifer A. Price
Battelle Memorial Institute
GenePathologymicroRNAGene expressionSystems biologyMolecular biologyGene expression profilingChemistryMicroarrayImmunologyWound healingSulfur mustardThermal injuryTranscription (biology)Influenza A virus subtype H5N1BioinformaticsSignal transductionMedicineMicroarray analysis techniquesBiologyDNA microarray
12Publications
8H-index
182Citations
Publications 12
Newest
#1Eric M. Vela (Battelle Memorial Institute)H-Index: 10
#2Manjula D. Kasoji (Battelle Memorial Institute)H-Index: 2
Last. James P. Long (Battelle Memorial Institute)H-Index: 8
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Influenza virus infections in humans remain a healthcare concern, and the need for vaccines, therapeutics and prophylactics remains a high priority. Understanding the molecular events associated with influenza-virus-induced pathology may lead to the identification of clinical disease biomarkers and novel antiviral targets. MicroRNAs (miRNAs) are well-conserved endogenous non-coding RNAs known to regulate post-transcriptional gene expression as well as play a major role in many biological process...
Source
#1Jennifer A. Price (Battelle Memorial Institute)H-Index: 8
#2James V. Rogers (Battelle Memorial Institute)H-Index: 16
Last. John S. GrahamH-Index: 18
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Chlorine is an industrial chemical that can cause cutaneous burns. Understanding the molecular mechanisms of tissue damage and wound healing is important for the selection and development of an effective post-exposure treatment. This study investigated the effect of cutaneous chlorine vapor exposure using a weanling swine burn model and microarray analysis. Ventral abdominal sites were exposed to a mean calculated chlorine vapor concentration of 2.9 g/L for 30 min. Skin samples were harvested at...
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#1James V. Rogers (Battelle Memorial Institute)H-Index: 16
#2Jennifer A. Price (Battelle Memorial Institute)H-Index: 8
Last. Herbert S. Bresler (Battelle Memorial Institute)H-Index: 12
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Abstract Within the past decade, human infections with the highly pathogenic avian influenza H5N1 have resulted in approximately 60% mortality and increased the need for vaccines and therapeutics. Understanding the molecular events associated with pathology can aid this effort; therefore, this study was conducted to assess microRNA (miRNA) expression in mouse lungs infected with H5N1 A/Vietnam/1203/04. Intranasal administration of 1500 median tissue culture infectious dose of H5N1 promoted diffe...
Source
#1Jennifer A. Price (Battelle Memorial Institute)H-Index: 8
#2James V. Rogers (Battelle Memorial Institute)H-Index: 16
Last. John S. GrahamH-Index: 18
view all 8 authors...
Bromine is an industrial chemical that causes severe cutaneous burns. When selecting or developing effective treatments for bromine burns, it is important to understand the molecular mechanisms of tissue damage and wound healing. This study investigated the effect of cutaneous bromine vapor exposure on gene expression using a weanling swine burn model by microarray analysis. Ventral abdominal sites were exposed to a mean calculated bromine vapor concentration of 0.51 g/L for 7 or 17 min. At 6 h,...
Source
#1James V. Rogers (Battelle Memorial Institute)H-Index: 16
#2Jennifer A. Price (Battelle Memorial Institute)H-Index: 8
Last. John S. GrahamH-Index: 18
view all 7 authors...
Bromine is an industrial chemical that can cause severe cutaneous burns. This study was a preliminary investigation into the effect of cutaneous exposure to bromine vapor using a weanling swine burn model and microarray analysis. Ventral abdominal sites were exposed to a mean calculated bromine vapor concentration of 0.69 g L−1 for 10 or 20 min. At 48 h postexposure, total RNA from skin samples was isolated, processed, and hybridized to Affymetrix GeneChip Porcine Genome Arrays. Expression analy...
Source
May 1, 2011 in ATS (American Thoracic Society International Conference)
#1Melissa G. Piper (OSU: Ohio State University)H-Index: 14
#2Richard GelinasH-Index: 25
Last. David J. Galas (University of Luxembourg)H-Index: 58
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Source
#1Ji-Hoon ChoH-Index: 24
#2Richard Gelinas (Battelle Memorial Institute)H-Index: 25
Last. Clay B. MarshH-Index: 68
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The molecular pathways involved in the interstitial lung diseases (ILDs) are poorly understood. Systems biology approaches, with global expression data sets, were used to identify perturbed gene networks, to gain some understanding of the underlying mechanisms, and to develop specific hypotheses relevant to these chronic lung diseases.
Source
#1James V. Rogers (Battelle Memorial Institute)H-Index: 16
#2Jennifer A. Price (Battelle Memorial Institute)H-Index: 8
Last. James N. McDougal (Wright State University)H-Index: 14
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Monitoring gene expression profiles in the skin using microarrays has become a useful approach to enhance the understanding of dermal function, toxicologic mechanisms, and risk assessment. With respect to cutaneous chemical exposure, there are few transcriptomic studies in the published literature, and these often differ in experimental design and availability of raw data. An assessment of multiple microarray data sets could be advantageous for identifying potential redundant biological mechanis...
Source
#1Jennifer A. Price (Battelle Memorial Institute)H-Index: 8
#2James V. Rogers (Battelle Memorial Institute)H-Index: 16
Last. John S. GrahamH-Index: 18
view all 6 authors...
Severe cutaneous injuries continue to result from exposure to sulfur mustard [bis(2-chloroethyl)sulfide; HD] and thermal burns. Microarray analysis was utilized in this study to evaluate transcriptional changes in porcine skin assessing the underlying repair mechanisms of HD and thermal injury involved in wound healing. Four ventral abdominal sites on each of 4 weanling swine were exposed to 400 μL undiluted HD or a heated brass rod (70°C) for 8 minutes and 45–60 seconds, respectively. At 7 days...
Source
#1James V. Rogers (Battelle Memorial Institute)H-Index: 16
#2James N. McDougal (Wright State University)H-Index: 14
Last. John S. GrahamH-Index: 18
view all 5 authors...
In military and civilian environments, serious cutaneous damage can result from thermal burns or exposure to the blistering agent sulfur mustard [bis (2-chloroethyl) sulfide; HD]. Similar therapies have historically been used to treat cutaneous thermal and HD injuries; however, the underlying molecular mechanisms of tissue damage and wound healing may differ between the types of burns. Using microarray analysis, this study assessed the transcriptional responses to cutaneous HD and thermal injury...
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