Peter C. Grayson
National Institutes of Health
Internal medicineRadiologyPathologyDermatologyIntensive care medicineImmunologyPositron emission tomographyVasculitisGiant cell arteritisSystemic vasculitisRelapsing polychondritisMicroscopic polyangiitisDiseaseTakayasu's arteritisGranulomatosis with polyangiitisArteritisLarge vessel vasculitisMedicineCohortGastroenterology
130Publications
25H-index
2,677Citations
Publications 121
Newest
#1H. Dashora (NIH: National Institutes of Health)H-Index: 1
#2Joel S. Rosenblum (NIH: National Institutes of Health)H-Index: 6
Last. Peter C. Grayson (NIH: National Institutes of Health)H-Index: 25
view all 8 authors...
The study rationale was to assess the performance of qualitative and semi-quantitative scoring methods for 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) assessment in large-vessel vasculitis (LVV). Methods: Patients with giant cell arteritis (GCA) or Takayasu's arteritis (TAK) underwent clinical and imaging assessment, blinded to each other, within a prospective observational cohort. FDG-PET-CT scans were interpreted for active vasculitis by central reader assessment. Arterial FD...
Source
Source
Source
#1Debashish DandaH-Index: 22
#2Ruchika GoelH-Index: 9
Last. Peter C. Grayson (NIH: National Institutes of Health)H-Index: 25
view all 9 authors...
Objectives To describe the clinical profile of Asian Indian patients with Takayasu's arteritis (TAK) and to compare clinical features and outcome of childhood-onset Takayasu's arteritis (cTAK) with adult-onset TAK (aTAK). Methods Data related to clinical features and response to treatment of patients with cTAK (age of onset Results Altogether, 602 patients (cTAK = 119; aTAK = 483) were studied. Patients with cTAK had a blunted female: male ratio; but fever, elevated acute phase reactants, involv...
1 CitationsSource
#1Jean-Paul Makhzoum (UdeM: Université de Montréal)H-Index: 3
#2Peter C. Grayson (NIH: National Institutes of Health)H-Index: 25
Last. Christian Pagnoux (U of T: University of Toronto)H-Index: 62
view all 9 authors...
Objectives This study describes the spectrum and initial impact of pulmonary manifestations in the primary systemic vasculitides. Methods Description and comparison of pulmonary manifestations in adults with Takayasu's arteritis (TAK), giant cell arteritis (GCA), granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (EGPA), polyarteritis nodosa (PAN), and IgA vasculitis (IgAV), using data collected within the Diagnostic and Classifi...
Source
#1Marcela A. Ferrada (NIH: National Institutes of Health)H-Index: 5
#2Keith A. Sikora (NIH: National Institutes of Health)H-Index: 5
Last. Peter C. Grayson (NIH: National Institutes of Health)H-Index: 25
view all 35 authors...
OBJECTIVE Somatic mutations in ubiquitin activating enzyme 1 (UBA1) cause a newly defined syndrome known as VEXAS. More than fifty percent of patients currently identified with VEXAS meet diagnostic criteria for relapsing polychondritis (RP). Clinical features that characterize VEXAS within a cohort of RP have not been defined. METHODS Exome and targeted sequencing of the UBA1 gene was performed in a prospective observational cohort of patients with RP. Clinical and immunological characteristics...
1 CitationsSource
#1Rennie L. Rhee (UPenn: University of Pennsylvania)H-Index: 9
#2Jiarui Lu (UPenn: University of Pennsylvania)
Last. Petra Merkel (UPenn: University of Pennsylvania)H-Index: 120
view all 14 authors...
OBJECTIVE Little is known about temporal changes in nasal bacteria in granulomatosis with polyangiitis (GPA). We examined longitudinal changes in the nasal microbiome in association with relapse in GPA patients. METHODS Bacterial 16S gene sequencing was performed on nasal swabs of 19 patients with GPA followed longitudinally for a total of 78 visits, including 9 patients who developed a relapse and 10 patients who remained in remission. Relative abundance of bacteria and ratios between bacteria ...
Source
#1Oskar Schnappauf (NIH: National Institutes of Health)H-Index: 5
#2Natalia Sampaio Moura (NIH: National Institutes of Health)H-Index: 5
Last. Petra Merkel (UPenn: University of Pennsylvania)H-Index: 120
view all 30 authors...
OBJECTIVE Deficiency of adenosine deaminase 2 (DADA2) is a monogenic form of vasculitis that can resemble polyarteritis nodosa (PAN). This study was undertaken to identify potential disease-causing sequence variants in ADA2 in patients with idiopathic PAN, granulomatosis with polyangiitis (GPA), or microscopic polyangiitis (MPA). METHODS Patients with idiopathic PAN (n = 118) and patients with GPA or MPA (n = 1,107) were screened for rare nonsynonymous variants in ADA2 using DNA sequencing metho...
2 CitationsSource
#1Dan Pugh (Edin.: University of Edinburgh)H-Index: 3
#2Peter C. Grayson (NIH: National Institutes of Health)H-Index: 25
Last. Neeraj Dhaun (Edin.: University of Edinburgh)H-Index: 26
view all 4 authors...
Broadly defined, aortitis refers to inflammation of the aorta and incorporates both infectious and non-infectious aetiologies. As advanced imaging modalities are increasingly incorporated into clinical practice, the phenotypic spectrum associated with aortitis has widened. The primary large vessel vasculitides, giant cell arteritis and Takayasu arteritis, are the most common causes of non-infectious aortitis. Aortitis without systemic disease or involvement of other vascular territories is class...
Source
#1Emily Rose (NIH: National Institutes of Health)H-Index: 1
#2Marcela A. Ferrada (NIH: National Institutes of Health)H-Index: 5
Last. Peter C. Grayson (NIH: National Institutes of Health)H-Index: 25
view all 12 authors...
OBJECTIVE Relapsing polychondritis (RP) is a systemic inflammatory disorder of cartilage that lacks validated disease activity measures. Physician global assessment (PhGA), a measure of disease activity commonly used in rheumatologic diseases, has not been tested in a cohort of patients with RP. METHODS Adult patients in an observational cohort of RP underwent standardized, comprehensive evaluation at approximately 6-month intervals. PhGA was scored by three physicians from the evaluating instit...
Source