Jing Zhou
Nanjing University of Chinese Medicine
Internal medicineCellMass spectrometryReceptorChemistryTraditional Chinese medicineApoptosisIn vivoMetabolomicsEx vivoCinobufaginVentricular tachycardiaInflammationVerapamilDocosahexaenoic acidBufoToadCardiotoxicityAntidoteVenomAnti-inflammatoryAnalgesicBufadienolideToad VenomToxicityChromatographyArsenicGut floraBiochemistryLipidomicsMedicineBiologyPharmacology
26Publications
8H-index
153Citations
Publications 26
Newest
#1Jiaojiao Wang (Nanjing University of Chinese Medicine)H-Index: 2
#2Dihui Xu (Nanjing University of Chinese Medicine)H-Index: 1
Last. Jing Zhou (Nanjing University of Chinese Medicine)H-Index: 8
view all 11 authors...
Abstract null null Long-term exposure to high levels of arsenic (As) will result in damage to organs. Compared with free arsenic, protein-bound arsenic are more difficult to be excreted from the bodies due to their complexation with biological macromolecules. We developed a method of size exclusion chromatography (SEC) and ion exchange chromatography (IEC) combined with inductively coupled plasma-mass spectrometry (ICP-MS) and multiple reaction monitoring (MRM) mode, which was used to determine ...
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#10Edyta Marcon (U of T: University of Toronto)H-Index: 20
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Traditional Chinese medicine injections (TCMIs) containing complex constituents frequently cause unpredictable adverse reactions. The residual heterologous proteins in TCMIs may be one kind of the sensitized constituents. However, few methods were developed to identify and monitor the residual proteins of TCMIs in industry. Here, we described a method combining the advantages of ultrafiltration and mass spectrometry-based proteomics for monitoring the potential residual proteins in Re Du Ning in...
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#1Jiaojiao Wang (Nanjing University of Chinese Medicine)H-Index: 2
#2Dihui Xu (Nanjing University of Chinese Medicine)H-Index: 1
Last. Jin-Ao Duan (Nanjing University of Chinese Medicine)H-Index: 55
view all 9 authors...
Inflammation is a primary defense and immune response. However, under pathological conditions, the inflammation processes always become uncontrolled and lead to chronic diseases. Bufotenine, as a natural component from toad venom, showed great potential for development as a novel anti-inflammation and analgesia agent. This study aimed to investigate the therapeutic effects of bufotenine against inflammation and pain on animal models with a focus on lipid metabolism. In pharmacological studies, b...
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#1Wei Zhang (Nanjing University of Chinese Medicine)H-Index: 4
#2Weiwei Tao (Nanjing University of Chinese Medicine)H-Index: 21
Last. Qinan Wu (Nanjing University of Chinese Medicine)H-Index: 17
view all 11 authors...
By a pilot trial on investigating immunomodulatory activity and target of ginsenosides, the major bioactive components of ginseng, here we report that structural analogues in herbal medicines hit a shared target to achieve cumulative bioactivity. A ginsenoside analogues combination with definite immunomodulatory activity in vivo was designed by integrating pharmacodynamics, serum pharmacochemistry and pharmacokinetics approaches. The cumulative bioactivity of the ginsenoside analogues was valida...
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#1Dihui Xu (Nanjing University of Chinese Medicine)H-Index: 1
#2Jiaojiao Wang (Nanjing University of Chinese Medicine)H-Index: 2
Last. Jin-Ao Duan (Nanjing University of Chinese Medicine)H-Index: 55
view all 8 authors...
Abstract Ethnopharmacological relevance Toad venom is one of widely used traditional Chinese medicines due to its analgesic and anti-inflammatory activities. However, hydrophilic alkaloids from toad venom, which may have certain pharmacological activities, have not been systematic studied. Aim of the study: The aim of the study was to identify the indolealkylamines (IAAs) from toad venom and investigate the analgesic and anti-inflammatory actions. Materials and methods The alkaloids were extract...
2 CitationsSource
#1Ye-Ting Zou (Nanjing University of Chinese Medicine)H-Index: 3
#2Jing Zhou (Nanjing University of Chinese Medicine)H-Index: 8
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
view all 9 authors...
Abstract Ethnopharmacological relevance Poria cocos (Schw.) Wolf (Poria) is a well-known traditional medicinal fungus. It has been considered to possess spleen-invigorating (Jianpi) effects in traditional Chinese medicine, and is used clinically to treat spleen deficiency (Pixu) with symptoms of intestinal disorders such as diarrhea, indigestion, mucositis and weight loss. The aim of this study To investigate the protective effects of Poria and its three component fractions (Water-soluble polysa...
2 CitationsSource
#1He Zhu (Nanjing University of Chinese Medicine)H-Index: 8
#2Yisheng He (CUHK: The Chinese University of Hong Kong)H-Index: 5
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
view all 9 authors...
Abstract Ethnopharmacological relevance Cyclophosphamide (CTX) is a first line chemotherapeutic agent, but often limited for its unstable therapeutic effect and serious side effects. Ginsenosides could facilitate the anti-tumor efficiency of CTX, including benefiting therapeutic effect and decreasing side effects. Aim of the study To investigate the potential mechanism of ginsenosides on benefiting the anti-tumor efficiency of CTX. Materials and methods Mammary carcinoma mice were applied to inv...
2 CitationsSource
#1Jiaojiao Wang (Nanjing University of Chinese Medicine)H-Index: 2
#2Lanfang DingH-Index: 1
Last. Jin-Ao Duan (Nanjing University of Chinese Medicine)H-Index: 55
view all 16 authors...
Abstract Ethnopharmacological relevance Liu-Shen-Wan (LSW) is one of the popular over-the-counter drugs in Asia, which contains realgar (As4S4), used for the treatment of upper respiratory tract inflammation and skin infections. However, the safety and potential risk of this arsenic remain unknown. Aim of the study The aim of this study was to determine total arsenic in tissue and investigate effects of regular dose and overdose LSW exposure on rat liver. Materials and methods We used a target l...
2 CitationsSource
#1Rongrong He (Nanjing University of Chinese Medicine)H-Index: 1
#2Hongyue Ma (Nanjing University of Chinese Medicine)H-Index: 9
Last. Jin-Ao DuanH-Index: 55
view all 12 authors...
In order to evaluate the quality of Bufonis Venenum commercial herbs, a three-step qualitative and quantitative research study was performed. Firstly, we tried to identify small molecules and peptides in Bufonis Venenum using pre-fractionation chromatography and high-resolution mass spectrometry. The database search of the small molecules and peptides of Bufonis Venenum revealed that the dried venom consisted of free/conjugated-type bufadienolides and peptides with a mass range of 0.4–2 kDa. Sec...
3 CitationsSource