Hao Yu
Jilin University
GeneInternal medicineEndocrinologyGenotypeUnfolded protein responsemicroRNAGene expressionSingle-nucleotide polymorphismMolecular biologyEndoplasmic reticulumTranscriptomeAndrologyChemistryApoptosisHaplotypeOxidative stressLinkage disequilibriumCancer researchViability assayGeneticsCell growthReprogrammingBiologyCell biology
61Publications
8H-index
239Citations
Publications 60
Newest
#1Zhen Shi (JLU: Jilin University)H-Index: 9
#2Zhiyuan Fang (JLU: Jilin University)H-Index: 5
Last. Guowen Liu (JLU: Jilin University)H-Index: 28
view all 11 authors...
Nuciferine (NF) has received extensive attention due to its medicinal value in the treatment of metabolic diseases, such as obesity; however, to date, the effects of NF on obesity-related intestinal permeability, autophagy and the gut microbiota have not been investigated. Herein, C57BL/6J mice were fed either a chow or a high-fat diet (HFD) with or without NF for 8 weeks. The results showed that NF supplement reduced weight gain, fat accumulation and intestinal permeability in the HFD mice acco...
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#1Zhen Shi (JLU: Jilin University)H-Index: 9
#2Yuxiang Song (JLU: Jilin University)H-Index: 8
Last. Guowen Liu (JLU: Jilin University)H-Index: 28
view all 12 authors...
Disruption of endoplasmic reticulum (ER) homeostasis, a condition termed "ER stress," contributes to the development of liver injury in nonruminants. Because liver injury is a prominent pathological feature associated with overproduction of ketone bodies in dairy cows with ketosis, understanding the ER stress state and its functional consequences on liver injury is of particular interest. Here, 30 multiparous cows (within 3 wk postpartum) classified based on blood β-hydroxybutyrate (BHB) as heal...
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#1Wenwen Gao (JLU: Jilin University)H-Index: 5
#2Zhiyuan Fang (JLU: Jilin University)H-Index: 5
Last. Xiliang Du (JLU: Jilin University)H-Index: 12
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Negative energy balance-induced high blood concentrations of free fatty acids during the early postpartum period in dairy cows is a major cause of liver injury. Cows in severe negative energy balance often have suboptimal intakes of feed, which contributes to shortfalls in production of ruminal propionate and circulating glucose. Although increasing propionate production by the rumen through feed additives such as propylene glycol is effective in helping cows alleviate the shortfall in dietary e...
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#1Jie SongH-Index: 2
#2Linlin HaoH-Index: 8
Last. Yunyun ChengH-Index: 1
view all 11 authors...
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#1Yanhui Zhai (JLU: Jilin University)H-Index: 5
#2Meng Zhang (JLU: Jilin University)H-Index: 9
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 9 authors...
Pre-implantation embryos undergo genome-wide DNA demethylation, however certain regions, like imprinted loci remain methylated. However, the mechanisms ensuring demethylation resistance by TRIM28 in epigenetic reprogramming remain poorly understood. Here, TRIM28 was knocked down in oocytes, and its effects on porcine somatic cell nuclear transfer (SCNT) embryo development was examined. Our results showed that SCNT embryos constructed from Trim28 knockdown oocytes had significantly lower cleavage...
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#1Ruihua LiH-Index: 4
#2Hengtong FangH-Index: 4
Last. Jing ZhangH-Index: 5
view all 10 authors...
Lipopolysaccharide (LPS) is an endotoxin, which may cause immune response and inflammation of bovine mammary glands. Mastitis impairs animal health and results in economic loss. Curcumin (CUR) is a naturally occurring diketone compound, which has attracted widespread attention as a potential anti-inflammatory antioxidant. The purpose of this study is to investigate whether CUR can reduce the damage of bovine mammary epithelial cells (MAC-T) induced by LPS and its underlying molecular mechanism. ...
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#1Daoyu Zhang (JLU: Jilin University)H-Index: 1
#2Xinglan An (JLU: Jilin University)H-Index: 10
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 4 authors...
Breast cancer is one of the most prevalent and reoccurring cancer types that leads to death in women. Triple-negative breast cancer (TNBC) is difficult to treat due to the lack of therapeutic targets. Many studies have focused on identifying drugs for use as alternative treatments for breast cancer. Thioguanine (6-TG) exerts antitumor effects in cancer. Increasing evidence has demonstrated that ceRNAs are involved in cancer processes. However, the mechanism by which 6-TG regulates lncRNA-miRNA-m...
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#1Yurong Fu (JLU: Jilin University)H-Index: 4
#2Yongcheng Jin (JLU: Jilin University)H-Index: 8
Last. Yue Tian (JLU: Jilin University)
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Zearalenone (ZEA) is a mycotoxin of the Fusarium genus that can cause endoplasmic reticulum (ER) stress and Apoptosis in bovine mammary epithelial cells (MAC-T). Polydatin (PD), a glycoside purified from Polygonum cuspidatum, has antioxidant properties. This study aimed to explore whether PD can alleviate ZEA-induced damage on bovine mammary epithelial cells (MAC-T). We found that incasing the concentration of ZEA (0, 7.5, 15, 30, 60, 90, 120, and 240 μM) gradually decreased the cell viability. ...
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#1Jing Zhang (JLU: Jilin University)H-Index: 5
#2JunMei Wang (Sichuan Agricultural University)
Last. Yongcheng Jin (JLU: Jilin University)H-Index: 8
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Abstract More and more studies have showed that tricothecene mycotoxin, deoxynivalenol (DON) caused cytotoxicity in mammary alveolar cells-large T antigen cells (MAC-T). Therefore, research on reducing the cytotoxicity of DON has gradually attracted attention. In this study, we aim to explore the potential of pterostilbene (PTE) to protect MAC-T cells from DON-induced oxidative stress and inflammatory response. MAC-T cells were treated with 0.25 μg/mL DON or 2.0504 μg/mL PTE or 0.25 μg/mL DON an...
1 CitationsSource
#1Hao Li (JLU: Jilin University)H-Index: 1
#2Xinglan An (JLU: Jilin University)H-Index: 10
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 5 authors...
Previous research has proven that 6-thioguanine (6-TG) inhibits the growth of MCF-7 breast cancer cells. Accumulating evidence indicates that long non-coding (lnc)RNAs are involved in the development of various cancer types as competitive endogenous (ce)RNA molecules. The present study was conducted to investigate the regulatory mechanism underlying the function of lncRNAs as ceRNA molecules in MCF-7 cells and to identify more effective prognostic biomarkers for breast cancer treatment. The expr...
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