Jianguo Wang
Northwest A&F University
Messenger RNAFGF21Subclinical infectionInternal medicineEndocrinologyAnimal scienceGene expressionMolecular biologyEndoplasmic reticulumAlkaline phosphataseFetusChemistryApoptosisIn vitroHepatocyteWestern blotLactationKetosisAMP-activated protein kinaseFatty liverNEFACartilageChondrocyteLipid oxidationLipid metabolismSecretionCopperMedicineVery low-density lipoproteinBiologyCell biology
33Publications
12H-index
323Citations
Publications 34
Newest
#1Yan Huang (NWAFU: Northwest A&F University)H-Index: 2
#2Jing Wen (NWAFU: Northwest A&F University)H-Index: 2
Last. Baoyu Zhao (NWAFU: Northwest A&F University)H-Index: 7
view all 12 authors...
Background null A better comprehension of the redox status during the periparturient period may facilitate the development of management and nutritional solutions to prevent subclinical hyperketonemia (SCHK) and subclinical hypocalcemia (SCHC) in dairy goats. We aimed to evaluate the variation in the redox status of dairy goats with SCHK and SCHC during their periparturient periods. Guanzhong dairy goats (n = 30) were assigned to SCHK (n = 10), SCHC (n = 10), and healthy (HEAL, n = 10) groups ba...
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#1Yan Huang (NWAFU: Northwest A&F University)H-Index: 2
#2Chenxu Zhao (NWAFU: Northwest A&F University)H-Index: 1
Last. Jianguo Wang (NWAFU: Northwest A&F University)H-Index: 12
view all 10 authors...
Abstract During the periparturient transition period, negative energy balance (NEB) characterized by high concentrations of non-esterified fatty acids (NEFA) may cause fatty liver and ketosis in dairy cows. Previous studies have shown that the protein kinase R-like endoplasmic reticulum kinase (PERK) branch of the endoplasmic reticulum stress (ERS) response plays an important role in lipid metabolism in hepatocytes. This study, therefore, investigated the role of the PERK-branch in NEFA-induced ...
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#8Binyun Cao (NWAFU: Northwest A&F University)H-Index: 14
#9Jianguo Wang (NWAFU: Northwest A&F University)H-Index: 12
Background: Dairy goats are highly susceptible to subclinical hyperketonemia (SCHK) during the transition period. This study aimed to compare the variation in metabolic parameters and surrogate indexes of insulin resistance (sIR) between goats with SCHK and clinically healthy (HEAL) goats during the transition period. Methods: Twenty Guanzhong dairy goats were assorted to HEAL (n = 10) and SCHK (n = 10) groups according to the blood β-hydroxybutyrate (BHBA) concentrations. The blood samples were...
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#1Yazhou GuoH-Index: 3
Last. Chonghui MoH-Index: 1
view all 12 authors...
Monocrotaline (MCT), one of pyrrolizidine alkaloids, is the major toxin in Crotalaria, which causes cell apoptosis in humans and animals. It has been reported that livers are the vulnerable target of MCT. However, the exact molecular mechanism of the interaction between endoplasmic reticulum (ER) stress and livers injury induced by MCT is still incompletely clearly. In this study, the cytotoxicity of MCT on primary rat hepatocytes was analysis by CCK-8 assay and Annexin V-FITC/PI assay. Protein ...
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#1Yezi Kong (NWAFU: Northwest A&F University)H-Index: 5
#2Chenxu Zhao (NWAFU: Northwest A&F University)H-Index: 1
Last. Jianguo Wang (NWAFU: Northwest A&F University)H-Index: 12
view all 10 authors...
In dairy cows, fatty liver is one of the most common metabolic diseases that occurs during the periparturient period. Angiopoietin-like protein 4 (ANGPTL4) is a well-known downstream target of peroxisome proliferator-activated receptors (PPARs), which regulate the glucose and fatty acid metabolisms. The inhibition of lipoprotein lipase (LPL) activity interferes with the storage of triglycerides (TG) in adipocytes, which plays an essential role in lipid metabolism in rodents. However, it remains ...
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#1Yazhou Guo (NWAFU: Northwest A&F University)H-Index: 3
#2Rong Guo (NWAFU: Northwest A&F University)H-Index: 3
Last. Baoyu Zhao (NWAFU: Northwest A&F University)H-Index: 7
view all 11 authors...
Monocrotaline (MCT) belongs to the category of Pyrrolizdine Alkaloids (PAs), which is one of important hepatotoxic alkaloid in Crotalaria Lin. Apoptosis is one mechanism of toxic responses induced by MCT. However, the underlying mechanism of liver apoptosis caused by MCT through Endoplasmic reticulum (ER) stress continues to be incompletely understood. In this study, we describe the role of ER stress in MCT induced hepatotoxicity in rats. 24 male rats were randomly divided into 3 groups: normal ...
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#1Jianguo Wang (NWAFU: Northwest A&F University)H-Index: 12
#2Xiaoyan Zhu (NWAFU: Northwest A&F University)H-Index: 8
Last. Baoyu Zhao (NWAFU: Northwest A&F University)H-Index: 7
view all 3 authors...
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#1Jinfeng Zhang (Qinghai University)H-Index: 1
#2Xiaoyan Zhu (NWAFU: Northwest A&F University)H-Index: 8
Last. Jianguo Wang (NWAFU: Northwest A&F University)H-Index: 12
view all 9 authors...
Abstract The trace element strontium has a significant impact on cartilage metabolism. However, the direct effects of strontium on alkaline phosphatase (ALP), a marker of bone growth, and bone morphogenetic protein-4 (BMP-4), which plays a key role in the regulation of bone and cartilage development, are not entirely clear. In order to understand the mechanisms involved in these processes, the chondrocytes were isolated from Wistar rat articular cartilage by enzymatic digestion and cultured unde...
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#1Xiaoyan Zhu (NWAFU: Northwest A&F University)H-Index: 8
#2Yezi Kong (NWAFU: Northwest A&F University)H-Index: 5
Last. Jianguo Wang (NWAFU: Northwest A&F University)H-Index: 12
view all 5 authors...
Strontium (Sr) can reduce cartilage degeneration and stimulate cartilage matrix formation. Angiogenesis plays a developmental role in chondrogenesis, and was stimulated by growth factors such as vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2). However, the direct influence of Sr on VEGF and FGF2 expressions in chondrocytes is not entirely clear. The objective of this study was to investigate the effects of different Sr concentrations on VEGF and FGF2 expressions i...
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#1Jianguo Wang (NWAFU: Northwest A&F University)H-Index: 12
#2Xiaoyan Zhu (NWAFU: Northwest A&F University)H-Index: 8
Last. Baoyu Zhao (NWAFU: Northwest A&F University)H-Index: 7
view all 8 authors...
During peripartum period, dairy cows are highly susceptible to energy metabolism disorders such as fatty liver and ketosis. Angiopoietin-like protein 4 (ANGPTL4) and fibroblast growth factor 21 (FGF21), known as hepatokines, play important roles in lipid metabolism. The purposes of our study were to evaluate variations of serum ANGPTL4 and FGF21 concentrations in periparturient dairy cows and changes in these serum analyte concentrations of energy-related metabolic disorders in early lactation d...
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