Xin Zhang
Sichuan Agricultural University
Messenger RNASignal peptideInternal medicineEndocrinologyGene expressionReceptorComplementary DNACloningCartSturgeonPostprandialApelinIntraperitoneal injectionSchizothorax prenantiAcipenser baeriiSequence alignmentOpen reading frameAppetiteBiologyUntranslated region
11Publications
7H-index
140Citations
Publications 13
Newest
#1Mei Wang (Sichuan Agricultural University)H-Index: 4
#2Shaoqi Xu (Sichuan Agricultural University)H-Index: 4
Last. Xin Zhang (Sichuan Agricultural University)H-Index: 7
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Abstract null null Amylin is a 37-amino acid polypeptide that has been found to be involved in feeding regulation in some mammals, birds, and goldfish. We cloned amylin of Siberian sturgeon and detected its distribution pattern in 15 tissues. The expression levels in the periprandial period (pre-and post-feeding), the changes in the food intake, and the expression levels of related appetite factors after the intraperitoneal injection of amylin were detected. The expression of amylin was found to...
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#1Ni TangH-Index: 6
#2Xin Zhang (Sichuan Agricultural University)H-Index: 7
Last. Zhiqiong Li (Sichuan Agricultural University)H-Index: 15
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Eating disorders and obesity are important health problems with a widespread global epidemic. Adiponectin (AdipoQ), the most abundant adipokine in the plasma, plays important roles in the regulation of energy homeostasis, glucose metabolism and lipid metabolism. Plasma adiponectin concentration is negatively associated with obesity and binge eating disorder. There is a growing interest in the appetite regulation function of adiponectin. However, the effect of AdipoQ on feeding behavior is contro...
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#1Dengyue Yuan (Sichuan Agricultural University)H-Index: 12
#2Yundi Gao (Sichuan Agricultural University)H-Index: 11
Last. Zhiqiong Li (Sichuan Agricultural University)H-Index: 15
view all 9 authors...
Abstract Neuropeptide Y (NPY) is the most powerful central neuropeptide implicated in feeding regulation via its receptors. Understanding the role of NPY system is critical to elucidate animal feeding regulation. Unlike mammal, the possible mechanisms of NPY system in the food intake of teleost fish are mostly unknown. Therefore, we investigated the regulatory mechanism of NPY and NPY receptors in Siberian sturgeon. In this study, we cloned the cDNA encoding NPY, and assessed the effects of diff...
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#1Ni Tang (Sichuan Agricultural University)H-Index: 6
#2Jin Hao (Sichuan Agricultural University)H-Index: 7
Last. Zhi Q. Li (Sichuan Agricultural University)H-Index: 1
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: Apela identified from zebrafish Danio rerio for the first time in 2013 is a novel endogenous peptide ligand for the apelin receptor. To study the role of apela in regulating fish feeding, the complementary (c) DNA sequence of apela of Siberian sturgeon Acipenser baerii was cloned for the first time. The apela cDNA fragment of 836 bp was obtained by cloning. The open reading frame (ORF) of apela was 165 bp encoding a 54 amino acid, including 22 amino acids signal peptide and two proteolytic sit...
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#1Xin Zhang (Sichuan Agricultural University)H-Index: 7
#2Yundi Gao (Sichuan Agricultural University)H-Index: 11
Last. Zhiqiong Li (Sichuan Agricultural University)H-Index: 15
view all 9 authors...
Cocaine- and amphetamine-regulated transcript (CART), discovered in 1995, with various biological functions, has received much attention recently due to its role in the regulation of appetite in mammals. However, the function of CART on the appetite control in fish species is still not very clear. In this study, Siberian sturgeon (Acipenser baerii Brandt) cart gene was cloned for the first time, and the cart mRNA levels in 11 feeding-related tissues was investigated. The Siberian sturgeon cart g...
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#1Xin Zhang (Sichuan Agricultural University)H-Index: 7
#2Ni Tang (Sichuan Agricultural University)H-Index: 6
Last. Zhiqiong Li (Sichuan Agricultural University)H-Index: 15
view all 11 authors...
To explore the effect of CCK on food intake in Siberian sturgeon, cck cDNA sequence of 1005 bp was obtained, and cck mRNA possessed the highest expression in brain. The expressions of cck were significantly increased after feeding 1 and 3 h, while displaying significant decrease after fasting within 15 days in brain and duodenum. Re-feeding for 3 days induced cck level returned to basic level. Acute i.p. injection experiment showed 100 and 200 ng/g BW CCK8 inhibited the food intake in 0–1 h toge...
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#1Jin Hao (Sichuan Agricultural University)H-Index: 7
#2Qing Liu (Dalian Ocean University)H-Index: 1
Last. Zhiqiong Li (Sichuan Agricultural University)H-Index: 15
view all 11 authors...
Abstract Apelin is a peptide, mainly produced in the brain, which participates in several physiologic effects. However, knowledge about the mechanism of appetite regulation in teleosts, including the role of apelin is not well understood. The aim of this study is to explore the effect of feeding status on the expression of apelin mRNA in the whole brain and the effects of injection of apelin on food intake in Siberian sturgeon ( Acipenser baerii ). In this study, we first cloned the apelin cDNA ...
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#1Xin Zhang (Sichuan Agricultural University)H-Index: 7
#2Yuanbing Wu (Sichuan Agricultural University)H-Index: 6
Last. Zhiqiong Li (Sichuan Agricultural University)H-Index: 15
view all 13 authors...
Abstract Urocortin-3 (UCN3), one of the corticotropin releasing factor (CRF) family peptides, which was discovered in 2001, has a variety of biological functions. However, the researches of UCN3 in fish were scarce. In order to understand whether UCN3 play a role in regulating food intake in fish, we first cloned the ucn3 cDNAs sequence of Siberian sturgeon ( Acipenser baerii Brandt), and investigated the ucn3 mRNA levels in 11 tissues. The Siberian sturgeon ucn3 cDNA sequence was 1044 bp, inclu...
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#1Yundan Pu (Sichuan Agricultural University)H-Index: 5
#2Jieyao Zhu (Sichuan Agricultural University)H-Index: 5
Last. Defang Chen (Sichuan Agricultural University)H-Index: 18
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Aquatic animals suffer from various environmental stresses because the aquatic environment is a very complex system. To monitor the health status of fish, Hsp90 a potential early warning marker was determined in Schizothorax prenanti after infection with a bacterium. In this study, we cloned Hsp90 from S. prenanti for the first time. The full-length cDNA sequence of SpHsp90 was 2663 bp, contains an open reading frame of 2181 bp, and has a gene encoding 726 amino acids, an estimated molecular mas...
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Spexin (SPX) is a novel peptide which was known for its role in physiological homeostasis. A recent study has confirmed that SPX plays an important role in the feeding regulation. However, the reports about SPX are very limited. In the present study, we characterized the structure, distribution and mRNA expression responses to feeding status of SPX in Ya-fish (Schizothorax prenanti). The full-length cDNA of Ya-fish SPX was 1330 base pairs (bp), which encoded 106 amino acid residues. These residu...
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