Jing Yang
University of Notre Dame
CancerPAX8Internal medicinePathologyOncologyCellAdipose tissueChemistryRhodopsinIn vitroImmunohistochemistryIn vivoLysophosphatidic acidRetinaPeritoneal cavityMetastasisContext (language use)Ovarian tumorOvarian cancerRetinalMesothelial CellCancer researchBiochemistryCarcinogenesisHistologyMedicineCell cultureBiologyCell biology
15Publications
6H-index
182Citations
Publications 10
Newest
#1Jing Yang (ND: University of Notre Dame)H-Index: 6
#2M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
Obesity has become a recognized global epidemic that is associated with numerous comorbidities including type II diabetes, cardiovascular disease, hypertension, and cancer incidence and progression. Ovarian cancer (OvCa) has a unique mechanism of intra-peritoneal metastasis, already present in 80% of women at the time of diagnosis, making it the fifth leading cause of death from gynecological malignancy. Meta-analyses showed that obesity increases the risk of OvCa progression, leads to enhanced ...
2 CitationsSource
#1Yuliya Klymenko (IU: Indiana University)H-Index: 8
#2Brandi Bos (ND: University of Notre Dame)H-Index: 1
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
view all 8 authors...
Epithelial ovarian cancer (EOC) metastasis occurs by exfoliation of cells and multicellular aggregates (MCAs) from the tumor into the peritoneal cavity, adhesion to and retraction of peritoneal mesothelial cells and subsequent anchoring. Elevated levels of lysophosphatidic acid (LPA) have been linked to aberrant cell proliferation, oncogenesis, and metastasis. LPA disrupts junctional integrity and epithelial cohesion in vitro however, the fate of free-floating cells/MCAs and the response of host...
1 CitationsSource
#1Yuliya Klymenko (IU: Indiana University)H-Index: 8
#2Brandi Bos (ND: University of Notre Dame)H-Index: 1
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
view all 8 authors...
Epithelial ovarian cancer (EOC) metastasis occurs by exfoliation of cells and multicellular aggregates (MCAs) from the tumor into the peritoneal cavity, adhesion to and retraction of peritoneal mesothelial cells and subsequent anchoring. Elevated levels of lysophosphatidic acid (LPA) have been linked to aberrant cell proliferation, oncogenesis, and metastasis. LPA disrupts junctional integrity and epithelial cohesion in vitro however, the fate of free-floating cells/MCAs and the response of host...
#1Elizabeth I. Harper (ND: University of Notre Dame)H-Index: 6
#2Elizabeth Loughran (ND: University of Notre Dame)H-Index: 7
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
view all 14 authors...
Ovarian cancer (OvCa) is the deadliest cancer of the female reproductive system, ranking fifth in overall cancer deaths among women. Unlike the majority of cancers, OvCa metastasizes via diffusion through the peritoneal cavity, resulting in multiple metastatic sites, including the omentum and peritoneum. These metastasizing OvCa cells induce rapid mesothelial cell retraction and readily adhere to the sub-mesothelial collagen of the extracellular matrix. Epidemiologic data identifies age as a sig...
Source
#1Jing Yang (ND: University of Notre Dame)H-Index: 6
#2William C. Kasberg (ND: University of Notre Dame)H-Index: 1
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
view all 6 authors...
: Membrane type 1 matrix metalloproteinase (MT1-MMP, MMP-14) is a transmembrane collagenase highly expressed in metastatic ovarian cancer and correlates with poor survival. Accumulating evidence shows that the cytoplasmic tail of MT1-MMP is subjected to phosphorylation, and this post-translational modification regulates enzymatic activity at the cell surface. To investigate the potential role of MT1-MMP cytoplasmic residue Thr567 phosphorylation in regulation of metastasis-associated behaviors, ...
10 CitationsSource
Ovarian cancer (OvCa) is the leading gynecological malignancy in women in the United States. OvCa metastasizes uniquely, spreading through the peritoneal cavity and generating widespread metastatic sites. The vast majority of OvCa cases occur in women over 40 and the median age at diagnosis is 63 (SEER). Despite age being a significant risk factor for the development of OvCa, there is a paucity of studies addressing the role of aging in OvCa metastasis. To our knowledge, there are no reports uti...
Source
Ovarian cancer is the most lethal gynecological cancer in U.S. women. Poor 5-year survival rates ( 90%. Metastasizing tumor cells grow rapidly and aggressively attach to the mesothelium of all organs within the peritoneal cavity, including the parietal peritoneum and the omentum, producing secondary lesions. Mesothelin (MSLN), a 40kDa glycoprotein that is over expressed in many cancers including ovarian and mesotheliomas is suggested to play a role in cell survival, proliferation, tumor progress...
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#1Anirban K. Mitra (IU: Indiana University)H-Index: 19
#2David A. Davis (UIC: University of Illinois at Chicago)H-Index: 7
Last. Joanna E. Burdette (UIC: University of Illinois at Chicago)H-Index: 29
view all 19 authors...
Abstract Objective Genomic studies of ovarian cancer (OC) cell lines frequently used in research revealed that these cells do not fully represent high-grade serous ovarian cancer (HGSOC), the most common OC histologic type. However, OC lines that appear to genomically resemble HGSOC have not been extensively used and their growth characteristics in murine xenografts are essentially unknown. Methods To better understand growth patterns and characteristics of HGSOC cell lines in vivo, CAOV3, COV36...
96 CitationsSource
#1Jing Yang (ND: University of Notre Dame)H-Index: 6
#2Joseph E. O'Tousa (ND: University of Notre Dame)H-Index: 26
The Drosophila genes ninaB and ninaD, encoding a β-carotene oxygenase and a type B scavenger receptor respectively, are essential for the biosynthesis of the 3-hydroxyretinal chromophore of rhodopsin. We analyzed transgenic reporter strains and performed in situ hybridization to show that both ninaB and ninaD are expressed in the adult brain but not retinal tissues. Developmental RT-PCR and tissue expression studies showed that ninaB is only expressed in the adult brain, while ninaD is expressed...
12 CitationsSource
#1Guie Gu (ND: University of Notre Dame)H-Index: 1
#2Jing Yang (ND: University of Notre Dame)H-Index: 6
Last. Joseph E. O'TousaH-Index: 26
view all 4 authors...
Abstract The Drosophila ninaB gene encodes a β,β-carotene-15,15′-oxygenase responsible for the centric cleavage of β-carotene that produces the retinal chromophore of rhodopsin. The ninaD gene encodes a membrane receptor required for efficient use of β-carotene. Despite their importance to the synthesis of visual pigment, we show that these genes are not active in the retina. Mosaic analysis shows that ninaB and ninaD are not required in the retina, and exclusive retinal expression of either gen...
33 CitationsSource