Hitomi Hamaoka
Osaka Medical College
VacuoleGlycoproteinCancerSpermatogenesisInternal medicineDownregulation and upregulationTFEBEndocrinologySomatic cellLymphatic systemChemistryApoptosisAutophagyImmunohistochemistryIn vivoTranscriptional regulationCD163Mammary tumorCD68Nitric oxide synthaseAdjuvant therapyFatty liverMetastasisLactoferrinMacrophageMitophagyLipoproteinAmyotrophic lateral sclerosisEntorhinal cortexLymphatic vesselLauric acidSertoli cellMitochondrionM2 MacrophageCancer researchCentral nervous systemFatty acidBrainstemApolipoprotein EAndrogen receptorParacrine signallingBiologyCell biology
Publications 5
#2Hitomi HamaokaH-Index: 3
Last. Yoichi Kondo (Shiga University of Medical Science)
view all 6 authors...
Lactoferrin (Lf) is an iron-binding glycoprotein mainly found in exocrine secretions and the secondary granules of neutrophils. In the central nervous system (CNS), expression of the Lf protein has been reported in the lesions of some neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, as well as in the aged brain. Lf is primarily considered an iron chelator, protecting cells from potentially toxic iron or iron-requiring microorganisms...
#1Masa-Aki Shibata (Osaka Medical College)H-Index: 26
#2Mariko Harada-ShibaH-Index: 39
Last. Yoichi Kondo (Osaka Medical College)H-Index: 21
view all 8 authors...
Lifestyle choices play a significant role in the etiology of atherosclerosis. Male Apoe−/− mice that develop spontaneous atherosclerotic lesions were fed 0%, 0.3%, and 0.4% mangosteen extracts, composed largely of α-mangostin (MG), for 17 weeks. Body weight gains were significantly decreased in both MG-treated groups compared to the control, but the general condition remained good throughout the study. The levels of total cholesterol (decreased very-low-density lipoprotein in lipoprotein profile...
7 CitationsSource
#1Masa-Aki Shibata (Osaka Medical College)H-Index: 26
#2Hitomi Hamaoka (Osaka Medical College)H-Index: 3
Last. Yoichi Kondo (Osaka Medical College)H-Index: 21
view all 8 authors...
: We previously reported that, in a mouse model of mammary cancer, α-mangostin alone exhibits anti-metastatic properties. To enhance this anti-metastatic effect, we examined the efficacy of synthetic α-mangostin dilaurate (MGD), prepared by adding lauric acid to α-mangostin, in the same experimental system wherein mice bearing mammary tumors are exposed to dietary MGD at 0, 2000 and 4000 ppm. Lauric acid has a high propensity for lymphatic absorption, which is the most common pathway of initial ...
4 CitationsSource
#1Nabil Eid (Osaka Medical College)H-Index: 13
#2Yuko Ito (Osaka Medical College)H-Index: 26
Last. Yoichi Kondo (Osaka Medical College)H-Index: 21
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: An emerging body of evidences based on in vitro studies indicate that mitophagy (selective autophagic clearance of damaged mitochondria) is a prosurvival mechanism, specifically under exposure to various stressors. Sertoli cells (SCs) play essential roles in maintenance of spermatogenesis via paracrine interactions with germ cells and other somatic cells in the testis; however, studies investigating mitophagy in SCs are still very few. In this chapter, we give a brief review of mechanisms and ...
3 CitationsSource
#1Akio Horibe (Osaka Medical College)H-Index: 4
#2Nabil Eid (Osaka Medical College)H-Index: 13
Last. Yoichi Kondo (Osaka Medical College)H-Index: 21
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This study was conducted to investigate the autophagic response of Sertoli cells (SCs) to acute ethanol toxicity using in vivo and in vitro models. Adult Wistar rats were intraperitoneally injected with either 5 g/kg ethanol or phosphate-buffered saline (for the control group) and sacrificed 0, 3, 6 and 24 h after injection. Compared to the control group, enhanced germ cell apoptosis was observed in the ethanol-treated rats (ETRs) in association with upregulation of iNOS and reduced expression o...
13 CitationsSource