Colleen Buggs-Saxton
Wayne State University
Internal medicineEndocrinologyEthnic groupBehavior changeMagnetic resonance imagingSelf-determination theorySocioeconomic statusDemographyGlucose transporterCarbohydrate metabolismChemistryPhysical therapyPediatricsGonadotropic cellEstrous cycleHealth equityPsychological interventionDiabetes managementMotivational interviewingFamily incomeMood disordersPituitary glandOvulationGlucose uptakeGLUT2GLUT1GirlAttendanceLuteinizing hormoneFatty liverGonadotropin-releasing hormoneMEDLINEGlycemicLMNAIntervention (counseling)Type 1 diabetesAtypiaNuclear atypiaOutreachPartial LipodystrophyGonadotroph CellGlucose Transporter Type 1Liver dysfunctionClinical trialDiabetes mellitusScale (social sciences)MedicineBiomarker (medicine)GerontologySocial determinants of healthCell cultureBiologyGastroenterology
Publications 8
#1Deborah A. Ellis (WSU: Wayne State University)H-Index: 32
#2Jillian Rhind (WSU: Wayne State University)
Last. Bassem H. Dekelbab (Boston Children's Hospital)H-Index: 7
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OBJECTIVES Adolescents of color are underrepresented in behavioral health research. Study aims were to quantify the amount and types of outreach effort needed to recruit young Black adolescents with type 1 diabetes and their primary caregiver into a clinical trial evaluating a parenting intervention and to determine if degree of recruitment difficulty was related to demographic, diabetes-related, or family characteristics. METHODS Data were drawn from a multi-center clinical trial. Participants ...
This article summarizes clinical observations and management strategies in pediatric type 1 diabetes (T1D) during the coronavirus disease 2019 (COVID-19) pandemic. Despite initial fears that children with diabetes would, similar to adults with diabetes, be at risk for severe COVID-19, most pediatric patients with a history of T1D who developed COVID-19 had mild disease or were asymptomatic similar to their peers without diabetes. The article also summarizes the use of telemedicine to provide ong...
#1Deborah A. Ellis (WSU: Wayne State University)H-Index: 32
#2Malcolm P. Cutchin (WSU: Wayne State University)H-Index: 9
Last. Jessica R Worley (WSU: Wayne State University)H-Index: 1
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While individual and family risk factors that contribute to health disparities in children with type 1 diabetes have been identified, studies on the effects of neighborhood risk factors on glycemic control are limited, particularly in minority samples. This cross-sectional study tested associations between family conflict, neighborhood adversity and glycemic outcomes (HbA1c) in a sample of urban, young Black adolescents with type 1 diabetes(mean age = 13.4 ± 1.7), as well as whether neighborhood...
#2Deborah A. EllisH-Index: 32
Last. Steven J. Ondersma (MSU: Michigan State University)H-Index: 26
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BACKGROUND Poor diabetes self-management in emerging adulthood (age 18-25 years) is associated with poorer diabetes health and diabetes complications. Emerging adults' focus on individuation and independence underlies their poor diabetes outcomes, offering a lever for behavior change. Self-determination theory (SDT) suggests that interventions leveraging emerging adults' innate developmental need for autonomy may offer a route to improving diabetes outcomes by increasing feelings of responsibili...
#1Nevin Ajluni (UM: University of Michigan)H-Index: 7
#2Rasimcan Meral (UM: University of Michigan)H-Index: 6
Last. Elif A. OralH-Index: 31
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SummaryContext Partial lipodystrophy (PL) is associated with metabolic co-morbidities but may go undiagnosed as the disease spectrum is not fully described. Objective The objective of the study was to define disease spectrum in PL using genetic, clinical (historical, morphometric) and laboratory characteristics. Design Cross-sectional evaluation. Participants Twenty-three patients (22 with familial, one acquired, 78·3% female, aged 12–64 years) with PL and non-alcoholic fatty liver disease (NAFL...
43 CitationsSource
#1Melissa Kaori Silva Litao (Boston Children's Hospital)H-Index: 2
#2Mohammad El-Baba (WSU: Wayne State University)H-Index: 7
Last. Colleen Buggs-Saxton (WSU: Wayne State University)H-Index: 3
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1 CitationsSource
Glucose provides fuel for cell metabolism and plays an important role in normal reproductive function. Glucose transporters such as (SLC2A1) facilitate entry of glucose into cells. We have previously shown that gonadotropin releasing hormone (GnRH) stimulates Slc2a1 expression in Li¢T2 gonadotrope cells and in the pituitary gland of pre-pubertal mice. In this study we examined changes in Slc2a1 expression in the pituitary gland of mice after puberty and in Li¢T2 gonadotrope cells treated with ...
3 CitationsSource
#1Valerie Michelle Harris (WSU: Wayne State University)H-Index: 1
#2Sachin V Bendre (BCM: Baylor College of Medicine)H-Index: 1
Last. Colleen Buggs-Saxton (WSU: Wayne State University)H-Index: 3
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GnRH is the main regulator of the hypothalamic–pituitary– gonadal (H–P–G) axis. GnRH stimulates the pituitary gonadotroph to synthesize and secrete gonadotrophins (LH and FSH), and this effect of GnRH is dependent on the availability of glucose and other nutrients. Little is known about whether GnRH regulates glucose metabolism in the gonadotroph. This study examined the regulation of glucose transporters (Gluts) by GnRH in the LbT2 gonadotroph cell line. Using real-time PCR analysis, the expres...
9 CitationsSource