Heinrich Patscheke
Heidelberg University
BiophysicsInternal medicineEndocrinologyInternalizationCardiologyThromboxane-A synthaseChemistrySerotoninThromboxaneFibrinolysisThrombinArachidonic acidReceptor antagonistCytochalasin BFibrinogenThromboxane A2ProstacyclinPlatelet activationFibrinogen bindingThromboxane receptorBiochemistryMedicinePlateletPharmacology
48Publications
18H-index
1,271Citations
Publications 47
Newest
#1Martin Möckel (Humboldt University of Berlin)H-Index: 46
Last. A. RufH-Index: 2
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The aims of this study were to evaluate whether platelets are activated during strenuous exercise in healthy athletes. Also, to determine the impact of plasmin and thrombin activity and catecholamine release. Previous studies have shown activation of the hemostatic system after competitive exercise, but platelet activation was thought to be absent in trained athletes. The impact of thrombin and other potent platelet activators is still a matter for debate. We examined 30 healthy triathletes duri...
37 CitationsSource
#1Meinrad Gawaz (TUM: Technische Universität München)H-Index: 27
#2Andreas RufH-Index: 17
Last. Albert SchömigH-Index: 102
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Resting platelets contain a substantial internal pool of GPIIb-IIIa complexes that is exposed on the surface of activated platelets. Whether the exposure of internal GPIIb-IIIa complexes on the activated platelet surface affects therapy with GPIIb-IIIa antagonists is poorly understood. We addressed this issue in thirteen patients who underwent elective coronary stenting and received abciximab. Platelet aggregation, surface expression of GPIIb-IIIa and P-selectin, receptor blockade of GPIIb-IIIa,...
47 CitationsSource
#1L. Röcker (FU: Free University of Berlin)H-Index: 19
#2S. GünayH-Index: 1
Last. Martin MöckelH-Index: 46
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■ Isometric exercise is a popular form of physical activity for many people. Only few studies exist on the effects of this type of exercise on the hemostatic system. Eleven male healthy subjects (21- 42 years) of varying fitness levels were investigated before, immediately after and 10 min after strenuous isometric exercise of the dominant arm. Blood samples were drawn by repetitive puncture from both the exercising and the contralateral arm. The following variables were studied: Prothrombin tim...
18 CitationsSource
#1Martin Möckel (Humboldt University of Berlin)H-Index: 46
#2Natalie-Viviane Ulrich (Humboldt University of Berlin)H-Index: 1
Last. Ulrich Frei (Humboldt University of Berlin)H-Index: 61
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17 CitationsSource
#1Karl Reuner (Heidelberg University)H-Index: 8
#2Andreas Ruf (Heidelberg University)H-Index: 17
Last. Heinrich Patscheke (Heidelberg University)H-Index: 18
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Background and Purpose—It has been recently reported that a G→A transition at nucleotide position 20210 in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increased risk of deep venous thrombosis. To date, it is unknown whether this polymorphism also represents a risk factor for cerebral venous thrombosis (CVT). Methods—Venous blood samples were collected from 45 patients with CVT and from 354 healthy blood donors as controls. A sec...
143 CitationsSource
#1Karl ReunerH-Index: 8
#2Andreas RufH-Index: 17
Last. Heinrich PatschekeH-Index: 18
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It has been reported recently by Poort et al. (1) that the mutation G20210→A in the 3′-untranslated region of the prothrombin gene is associated with increased plasma prothrombin concentrations and venous thrombosis. The G20210→A mutation was found in 18% of 28 selected patients with a personal and family history of venous thrombosis as well as in 6.2% of 471 unselected patients with a first episode of deep venous thrombosis. On the other hand, only 2.3% of 474 healthy control subjects carried t...
11 CitationsSource
#1Armin J. Grau (Heidelberg University)H-Index: 47
#2Andreas RufH-Index: 17
Last. Werner HackeH-Index: 137
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Determination of circulating activated platelets may be helpful to estimate the prognosis and to stratify therapies in arterial vascular disorders including stroke. We used flow cytometry and phase contrast microscopy to study whether the fraction of platelets expressing p-selectin and CD63 and the fraction of platelets with shape change are increased in patients with acute and previous cerebrovascular ischemia. The proportion of platelets expressing activation dependent antigens was higher in p...
88 CitationsSource
#1Karl ReunerH-Index: 8
#2Andreas RufH-Index: 17
Last. Heinrich PatschekeH-Index: 18
view all 5 authors...
22 CitationsSource
#1Karl ReunerH-Index: 8
#2Michael ElgasH-Index: 1
Last. Heinrich PatschekeH-Index: 18
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8 CitationsSource
#1L. RöckerH-Index: 19
Last. Martin MöckelH-Index: 46
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