Hong Xie
Guangzhou University of Chinese Medicine
AdductElectron transferRadicalMedicinal chemistryChemistryStructure–activity relationshipRutinLuteolinOxidative stressNaringeninAntioxidantGallic acidMTT assayABTSDPPHIc50 valuesMs analysisTandem mass spectrometryElectrospray ionizationChromatographyBiochemistryDouble bondStereochemistry
16Publications
10H-index
207Citations
Publications 16
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#1Xiaojian Ouyang (Guangzhou University of Chinese Medicine)H-Index: 5
#2Xican Li (Guangzhou University of Chinese Medicine)H-Index: 19
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 10 authors...
Erastin-treated bone marrow-derived mesenchymal stem cells (bmMSCs) were prepared and used to compare the ferroptosis inhibitory bioactivities of four monostilbenes, including rhapontigenin (1a), isorhapontigenin (1b), piceatannol-3′-O-glucoside (1c), and rhapontin (1d). Their relative levels were 1c ≈ 1b > 1a ≈ 1d in 4,4-difluoro-5-(4-phenyl-1,3-butadienyl)-4-bora-3a,4a-diaza-s-indacene-3-undecanoic acid (C11-BODIPY), 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), and flow ...
3 CitationsSource
#1Rongxin Cai (Guangzhou University of Chinese Medicine)H-Index: 3
#2Xican Li (Guangzhou University of Chinese Medicine)H-Index: 19
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 6 authors...
6 CitationsSource
#1Minshi Liang (Guangzhou University of Chinese Medicine)H-Index: 4
#2Xican Li (Guangzhou University of Chinese Medicine)H-Index: 9
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 5 authors...
Echinatin and its 1,1-dimethyl-2-propenyl derivative licochalcone A are two chalcones found in the Chinese herbal medicine Gancao. First, their antioxidant mechanisms were investigated using four sets of colorimetric measurements in this study. Three sets were performed in aqueous solution, namely Cu2+-reduction, Fe3+-reduction, and 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide radical (PTIO•)-scavenging measurements, while 1,1-diphenyl-2-picrylhydrazyl radical (DPPH•)-scavenging colori...
21 CitationsSource
#1Xican Li (Guangzhou University of Chinese Medicine)H-Index: 9
#2Zhenxing Ren (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
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Sanggenons C and D are two Diels-Alder-type adducts from Chinese crude drug Sang-bai-pi. Structurally, both sanggenons construct stereoisomers. In the study, they were comparatively determined using four antioxidant assays, including ferric ion reducing antioxidant power (FRAP) assay, Cu2+-reducing assay, 1,1-diphenyl-2-picryl-hydrazl (DPPH•)-scavenging assay, and 2,2′-azino-bis (3-ethylbenzo-thiazoline-6-sulfonic acid radical (ABTS•+)-scavenging assay. Their Fe2+-binding reactions were explored...
4 CitationsSource
#1Xican Li (Guangzhou University of Chinese Medicine)H-Index: 19
#2Ban Chen (Guangzhou University of Chinese Medicine)H-Index: 8
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 6 authors...
The study determined the comparative antioxidant capacities of five similar dihydrochalcones: phloretin, phloridzin, trilobatin, neohesperidin dihydrochalcone, and naringin dihydrochalcone. In the ferric-reducing antioxidant power (FRAP) assay, the antioxidant activities of pairs of dihydrochalcones had the following relationship: phloretin > phloridzin, phloretin > trilobatin, trilobatin > phloridzin, trilobatin > naringin dihydrochalcone, and neohesperidin dihydrochalcone > naringin dihydrocha...
41 CitationsSource
#1Xican Li (Guangzhou University of Chinese Medicine)H-Index: 9
#2Jian Lin (Guangzhou University of Chinese Medicine)H-Index: 7
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 5 authors...
In this study, two natural phenolic polyamines, kukoamine A and B, were comparatively investigated for their antioxidant and cytoprotective effects in Fenton-damaged bone marrow-derived mesenchymal stem cells (bmMSCs). When compared with kukoamine B, kukoamine A consistently demonstrated higher IC50 values in PTIO•-scavenging (pH 7.4), Cu2+-reducing, DPPH•-scavenging, •O2−-scavenging, and •OH-scavenging assays. However, in the PTIO•-scavenging assay, the IC50 values of each kukoamine varied with...
12 CitationsSource
#1Xican Li (Guangzhou University of Chinese Medicine)H-Index: 9
#2Hong Xie (Guangzhou University of Chinese Medicine)H-Index: 10
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 4 authors...
Two 2-phenyl-benzofurans, moracin C {2-[3′,5′-dihydroxy-4′-(3-methlbut-2-enyl)phenyl]-6-hydroxybenzofuran} and its isomer iso-moracin C{2-[3′,5′-dihydroxy-4′-(3-methlbut-1-enyl)phenyl]-6-hydroxybenzofuran}, were comparatively studied using redox-related antioxidant assays and non-redox antioxidant assays. Moracin C always resulted in higher IC50 values than iso-moracin C in the redox-related antioxidant assays, including •O2−-inhibition, Cu2+-reducing power, DPPH•-inhibition, and ABTS+•-inhibiti...
16 CitationsSource
#1Xican Li (Guangzhou University of Chinese Medicine)H-Index: 19
#2Yulu Xie (Guangzhou University of Chinese Medicine)H-Index: 6
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 5 authors...
α-Viniferin and caraphenol A, the two oligostilbenes, have the sole difference of the presence or absence of an exocyclic double bond at the π-π conjugative site. In this study, the antioxidant capacity and relevant mechanisms for α-viniferin and caraphenol A were comparatively explored using spectrophotometry, UV-visible spectral analysis, and electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UPLC–ESI–Q–TOF–MS/MS) analysis. The spectrophotometric results suggested that...
15 CitationsSource
#1Xican Li (Guangzhou University of Chinese Medicine)H-Index: 9
#2Yulu Xie (Guangzhou University of Chinese Medicine)H-Index: 6
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 11 authors...
The study tried to explore the role of sugar-residues and mechanisms of phenolic phenylpropanoid antioxidants. Acteoside, along with its apioside forsythoside B and rhamnoside poliumoside, were comparatively investigated using various antioxidant assays. In three electron-transfer (ET)-based assays (FRAP, CUPRAC, PTIO•-scavenging at pH 4.5), the relative antioxidant levels roughly ruled as: acteoside >forsythoside B > poliumoside. Such order was also observed in H+-transfer-involved PTIO•-scaven...
16 CitationsSource