Yu-Hsuan A. Chang
University of California, San Diego
RecallFluid-attenuated inversion recoveryQuality of lifeVerbal memoryNeuriteWater mazeInternal medicineRadiologyEndocrinologyTournamentDevelopmental psychologyJob designNeuropsychologyMagnetic resonance imagingOncologyHippocampal formationDiffusion MRIDominance (genetics)PsychologyConcordanceNeurologyEmpirical evidenceNeuroscienceCognitionLateralityCommon spatial patternCognitive psychologyCore languageOasis mazeVariance (accounting)Working memoryMemoriaSeparation (statistics)Frontal lobeCingulum (brain)NeocortexSuperior temporal gyrusEpilepsyGliomaTrail Making TestTest (assessment)Posterior cingulateEpilepsy syndromesDepression (differential diagnoses)Functional magnetic resonance imagingMemory disorderUncinate fasciculusArcuate fasciculusExecutive dysfunctionStriatumTask (project management)Inferior longitudinal fasciculusTemporal lobeWhite matterMolecular classificationFluid intelligenceIndirect evidenceInferior parietal cortexTemporal cortexVerbal learningConceptual processingTissue heterogeneityIn patientSensitivity to changeMixed effectsMemory impairmentOptimal combinationVentricular volumeMemory performanceClinical settingsMedical imagingMathematicsAssertionSpatial memoryMorris water navigation taskAgeingSenescenceAudiologyCHRESTNeuroimagingCognitive flexibilityResting state fMRIReinforcementCognitive reserveClinical psychologyLatent learningMedicineChild prodigyGerontologyBehavioral patternSemantic networkEpisodic memoryWechsler Adult Intelligence ScaleFractional anisotropyRecognition memoryAnalysis of variance
17Publications
7H-index
157Citations
Publications 16
Newest
#1Ghiam Yamin (UCSD: University of California, San Diego)H-Index: 14
#2Piyaphon Cheecharoen (UCSD: University of California, San Diego)H-Index: 1
Last. Nikdokht Farid (UCSD: University of California, San Diego)H-Index: 17
view all 8 authors...
Objective:Computerized tomography (CT) is the mainstay imaging modality for assessing change in ventricular volume in patients with ventricular shunts or external ventricular drains (EVDs). We eval...
1 CitationsSource
#1Erik Kaestner (UCSD: University of California, San Diego)H-Index: 10
#2Anny Reyes (UCSD: University of California, San Diego)H-Index: 10
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 7 authors...
OBJECTIVE: To identify neuroimaging and clinical biomarkers associated with a language-impaired phenotype in refractory temporal lobe epilepsy (TLE). METHODS: Eighty-five patients with TLE were characterized as language-impaired (TLE-LI) or non-language-impaired (TLE-NLI) based on comprehensive neuropsychological testing. Structural magnetic resonance imaging (MRI), diffusion tensor imaging, and functional MRI (fMRI) were obtained in patients and 47 healthy controls (HC). fMRI activations and co...
14 CitationsSource
#1Yu-Hsuan A. Chang (UCSD: University of California, San Diego)H-Index: 7
#2Anisa Marshall (UCSD: University of California, San Diego)H-Index: 5
Last. Carrie R. McDonaldH-Index: 38
view all 11 authors...
OBJECTIVES: Temporal lobe epilepsy (TLE) is known to affect large-scale gray and white matter networks, and these network changes likely contribute to the verbal memory impairments observed in many patients. In this study, we investigate multimodal imaging patterns of brain alterations in TLE and evaluate the sensitivity of different imaging measures to verbal memory impairment. METHODS: Diffusion tensor imaging (DTI), volumetric magnetic resonance imaging (vMRI), and resting-state functional MR...
4 CitationsSource
#1Tobin J. Ehrlich (Palo Alto University)H-Index: 2
#2Anny Reyes (UCSD: University of California, San Diego)H-Index: 10
Last. Carrie R. McDonaldH-Index: 38
view all 10 authors...
Abstract Objective Individuals with temporal lobe epilepsy (TLE) often experience diminished quality of life (QoL). Although comorbid depression is one of the most recognized predictors of poor QoL in TLE, impairments in verbal memory (VM) and executive functioning (EF), have also been identified as risk factors, independent of other biological and psychosocial factors. In this study, we examine the contribution of depression, VM, and EF to QoL in 52 well-characterized medically-refractory TLE p...
4 CitationsSource
#1Naeim Bahrami (UCSD: University of California, San Diego)H-Index: 12
#2Stephen J. Hartman (UCSD: University of California, San Diego)H-Index: 2
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 12 authors...
Background Molecular markers of WHO grade II/III glioma are known to have important prognostic and predictive implications and may be associated with unique imaging phenotypes. The purpose of this study is to determine whether three clinically relevant molecular markers identified in gliomas—IDH, 1p/19q, and MGMT status—show distinct quantitative MRI characteristics on FLAIR imaging.
18 CitationsSource
#1Anny Reyes (UCSD: University of California, San Diego)H-Index: 10
#2Brianna M. Paul (UCSF: University of California, San Francisco)H-Index: 11
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 10 authors...
OBJECTIVE: Bilingual healthy adults have been shown to exhibit an advantage in executive functioning (EF) that is associated with microstructural changes in white matter (WM) networks. Patients with temporal lobe epilepsy (TLE) often show EF deficits that are associated with WM compromise. In this study, we investigate whether bilingualism can increase cognitive reserve and/or brain reserve in bilingual patients with TLE, mitigating EF impairment and WM compromise. METHODS: Diffusion tensor imag...
6 CitationsSource
#1Yu-Hsuan A. Chang (UCSD: University of California, San Diego)H-Index: 7
#2Sogol Stephanie Javadi (UCSD: University of California, San Diego)H-Index: 3
Last. Carrie R. McDonald (SDSU: San Diego State University)H-Index: 38
view all 6 authors...
Abstract Blocked and event-related fMRI designs are both commonly used to localize language networks and determine hemispheric dominance in research and clinical settings. We compared activation profiles on a semantic monitoring task using one of the two designs in a total of 43 healthy individual to determine whether task design or subject-specific factors (i.e., age, sex, or language performance) influence activation patterns. We found high concordance between the two designs within core langu...
3 CitationsSource
#1David M. Lane (Rice University)H-Index: 56
#2Yu-Hsuan A. Chang (Rice University)H-Index: 7
The expertise effect in memory for chess positions is one of the most robust effects in cognitive psychology. One explanation of this effect is that chess recall is based on the recognition of familiar patterns and that experts have learned more and larger patterns. Template theory and its instantiation as a computational model are based on this explanation. An alternative explanation is that the expertise effect is due, in part, to stronger players having better and more conceptual knowledge, w...
12 CitationsSource
#1Anny Reyes (UCSD: University of California, San Diego)H-Index: 10
#2Heather M. Holden (UCSD: University of California, San Diego)H-Index: 7
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 10 authors...
Abstract Individuals with chronic temporal lobe epilepsy (TLE) experience episodic memory deficits that may be progressive in nature. These memory decrements have been shown to increase with the extent of hippocampal damage, a hallmark feature of TLE. Pattern separation, a neural computational mechanism thought to play a role in episodic memory formation, has been shown to be negatively affected by aging and in individuals with known hippocampal dysfunction. Despite the link between poor pattern...
19 CitationsSource
#1Anny Reyes (UCSD: University of California, San Diego)H-Index: 10
#2Vedang S. Uttarwar (UCSD: University of California, San Diego)H-Index: 5
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 8 authors...
Abstract Objective Executive dysfunction is observed in a sizable number of patients with refractory temporal lobe epilepsy (TLE). The frontostriatal network has been proposed to play a significant role in executive functioning, however, because of the complex architecture of these tracts, it is difficult to generate measures of fiber tract microstructure using standard diffusion tensor imaging. To examine the association between frontostriatal network compromise and executive dysfunction in TLE...
11 CitationsSource