Daniel Kirschenbaum
University of Zurich
PathologyWhisking in animalsStimulus (physiology)NeuroscienceElectrophysiologyChemistryCell typePneumoniaEncephalopathyThalamusInterneuronAutopsyNeuropathologyBarrel cortexAction potential initiationCentral nervous systemMedicineBiologyAmyloidSensory system
Publications 22
#1Daniel Kirschenbaum (UZH: University of Zurich)H-Index: 6
#2Lukas L. Imbach (UZH: University of Zurich)H-Index: 12
Last. Karl Frontzek (UZH: University of Zurich)H-Index: 10
view all 15 authors...
Coronavirus disease 19 (COVID-19), caused by infection with the severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2), has become a worldwide pandemic (1). Symptoms of COVID-19 vary widely and range from asymptomatic disease to severe pneumonia and multiorgan failure (2). A severe disease course is more likely in older patients and patients with pre-existing respiratory and cardiovascular conditions (2). Patients with severe Sars-CoV-2 infection may present with ischaemic stroke (3, 4) or...
10 CitationsSource
#1Christopher J. Love (MIT: Massachusetts Institute of Technology)
#1Christopher J. Love (MIT: Massachusetts Institute of Technology)H-Index: 3
Last. Adriano Aguzzi (UZH: University of Zurich)H-Index: 111
view all 7 authors...
Background and Purpose: The classic presentation of chronic (stage III) hemorrhagic stroke lesions is a fluid-filled cavity. In one of the most commonly used animal models of intracerebral hemorrha...
#2Fabian F. Voigt (UZH: University of Zurich)H-Index: 12
Last. Adriano Aguzzi (UZH: University of Zurich)H-Index: 111
view all 13 authors...
Genetic and biochemical evidence suggests a role for amyloid-{beta} (A{beta}) in Alzheimer's disease, yet many anti-A{beta} treatments are clinically ineffective. Regional heterogeneity of efficacy may contribute to these disappointing results. Here we compared the regiospecificity of various anti-A{beta} treatments by combining focused electrophoretic whole-brain clearing, amyloid labelling and light-sheet imaging with whole-brain analyses of plaque topology in A{beta}-overexpressing mice. A{be...
#1Rahel Kastli (UZH: University of Zurich)H-Index: 3
#2Rasmus Vighagen (UZH: University of Zurich)
Last. Theofanis Karayannis (UZH: University of Zurich)H-Index: 14
view all 10 authors...
#1Emanuela Keller (UZH: University of Zurich)H-Index: 21
#2Giovanna Brandi (UZH: University of Zurich)H-Index: 9
Last. Ilijas Jelcic (UZH: University of Zurich)H-Index: 20
view all 19 authors...
Background and Purpose: Case series indicating cerebrovascular disorders in coronavirus disease 2019 (COVID-19) have been published. Comprehensive workups, including clinical characteristics, labor...
18 CitationsSource
#1Daniel Kirschenbaum (UZH: University of Zurich)H-Index: 6
#2Lukas L. Imbach (UZH: University of Zurich)H-Index: 12
Last. Karl Frontzek (UZH: University of Zurich)H-Index: 10
view all 13 authors...
We report two cases of olfactory neuropathy diagnosed at autopsy in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. One patient experienced anosmia. Information about anosmia was not available in the other patient. Patient 1, a man aged 70 years, and patient 2, a man aged 79 years, both tested positive for SARS-CoV-2. Patient 1 was a renal transplant recipient with coronary artery disease and arterial hypertension. He developed progressive respiratory failur...
25 CitationsSource
#1Emanuela KellerH-Index: 21
#2Giovanna BrandiH-Index: 9
Last. Ilijas JelcicH-Index: 20
view all 16 authors...
Objective Case series with different clinical presentations indicating central nervous system (CNS) involvement in coronavirus disease 2019 (COVID-19) have been published. Comprehensive work-ups including clinical characteristics, laboratory, electroencephalography (EEG), neuroimaging and cerebrospinal fluid (CSF) findings are needed to understand the mechanisms. Design We evaluated 32 consecutive patients with severe SARS-CoV-2 infection treated at a tertiary care centre from March 09 to April ...
#1Ruiqing Ni (UZH: University of Zurich)H-Index: 12
#2Xose Luis Dean-Ben (UZH: University of Zurich)H-Index: 4
Last. Jan Klohs (UZH: University of Zurich)H-Index: 19
view all 13 authors...
Deposition of beta-amyloid deposits is one major histopathological hallmark of Alzheimer′s disease (AD). Here, we introduce volumetric multi-spectral optoacoustic tomography (vMSOT), which covers 10×10×10 mm3 field-of-view, capable of 3D whole mouse brain imaging. We show for the first time the optoacoustic properties of oxazine-derivative AOI987 probe, which binds to beta-amyloid, and the application of vMSOT for the quantification of brain-wide beta-amyloid; deposition. Administration of AOI98...
3 CitationsSource
#1Fabian F. Voigt (UZH: University of Zurich)H-Index: 12
#2Daniel Kirschenbaum (UZH: University of Zurich)H-Index: 6
Last. Fritjof Helmchen (UZH: University of Zurich)H-Index: 55
view all 30 authors...
Light-sheet microscopy is an ideal technique for imaging large cleared samples; however, the community is still lacking instruments capable of producing volumetric images of centimeter-sized cleared samples with near-isotropic resolution within minutes. Here, we introduce the mesoscale selective plane-illumination microscopy initiative, an open-hardware project for building and operating a light-sheet microscope that addresses these challenges and is compatible with any type of cleared or expand...
55 CitationsSource
#1Ann-Katrin Rodewald (UZH: University of Zurich)H-Index: 3
#2Elisabeth J. Rushing (UZH: University of Zurich)H-Index: 40
Last. Daniela Mihic-Probst (UZH: University of Zurich)H-Index: 22
view all 9 authors...
BACKGROUND: Metastatic tumor spread is a complex multistep process. Due to the blood-brain barrier, metastasis to the central nervous system is restrictive with a distinct predilection for certain tumor types. In melanoma patients, brain metastasis is a common endpoint with the majority showing evidence of widespread disease at autopsy. In a previous murine melanoma model, we have shown that melanoma cells migrate along preexisting vessels into the brain, showing angiotropism/vascular co-option ...
6 CitationsSource