Dong Hoon Shin
Pusan National University
CancerInternal medicineRadiologySurgeryPathologyOncologyTissue microarrayImmunohistochemistryLung cancerCarcinomaLungDiffuse large B-cell lymphomaMetastasisLymphomaRituximabLymph nodeCancer/testis antigensAdenocarcinomaPapillary thyroid cancerCancer researchColorectal cancerCarcinogenesisMedicineBiology
88Publications
17H-index
786Citations
Publications 87
Newest
#1Hyun Jung Lee (PNU: Pusan National University)H-Index: 9
#2Dong Hoon Shin (PNU: Pusan National University)H-Index: 1
Last. Sung Woo Park (PNU: Pusan National University)H-Index: 11
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ABSTRACT null null The efficacy of PD-L1/PD-1 checkpoint blockade in renal cell carcinoma remains unknown. Moreover, the effects of mTOR inhibitors are uncertain, and patients may develop resistance to them. The limited understanding of cancer cell-intrinsic mTOR-mediated pathways remains a challenge in developing effective treatments. We investigated whether Transcription factor E3 (TFE3) regulates PD-L1 expression and the tumor microenvironment and explored the effects of an mTOR inhibitor in ...
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#1Hwaseong Ryu (PNU: Pusan National University)H-Index: 4
#2Jae-Yeon Hwang (PNU: Pusan National University)H-Index: 13
Last. Dong Hoon Shin (PNU: Pusan National University)H-Index: 17
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BACKGROUND Rosai-Dorfman disease (RDD) is a rare histiocytic proliferation of unknown etiology commonly found in children and adolescents. The common manifestation of RDD is massive and painless bilateral cervical lymphadenopathy with extranodal disease. While extranodal involvement in RDD is common, the spleen is an infrequent site of disease. CASE SUMMARY We report a 10-mo-old female infant with RDD presenting multiple splenic masses without cervical lymphadenopathy. She had fever, and blood t...
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#1Hye-Jin Kim (PNU: Pusan National University)H-Index: 5
#2Dong Hoon Shin (PNU: Pusan National University)H-Index: 17
Last. Hye Ju Yeo (PNU: Pusan National University)H-Index: 11
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During the present COVID-19 pandemic, transplantation of donor lungs with a history of COVID-19 infection is a critical issue. Donor-derived virus infection and graft dysfunction are possible after transplantation. However, use of such lungs could save the lives of patients requiring emergency transplantation. We successfully transplanted lungs from a brain-dead donor who had recovered from SARS-CoV-2 into a severe respiratory failure patient supported with ECMO who needed an emergency transplan...
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#1Ye-Rin KimH-Index: 2
#2Kiuk KimH-Index: 2
Last. Sang-Yull LeeH-Index: 10
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To identify cancer/testis (CT) antigens and immunogenic proteins, immunoscreening of testicular and small-cell lung cancer cell line NCI-H889 cDNA libraries was performed using serum obtained from a small-cell lung cancer (SCLC) patient. We obtained 113 positive cDNA clones comprised of 74 different genes, designated KP-SCLC-1 through KP-SCLC-74. Of these genes, 59 genes were found to be related to cancers by EMBASE analysis. Three of these antigens, including KP-SCLC-29 (NOL4), KP-SCLC-59 (CCDC...
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#1Sunhee Chang (Inje University)H-Index: 9
#2Hyo Sup Shim (Yonsei University)H-Index: 28
Last. Chang Hun Lee (PNU: Pusan National University)H-Index: 27
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Molecular biomarker testing is the standard of care for non-small cell lung cancer (NSCLC) patients. In 2017, the Korean Cardiopulmonary Pathology Study Group and the Korean Molecular Pathology Study Group co-published a molecular testing guideline which contained almost all known genetic changes that aid in treatment decisions or predict prognosis in patients with NSCLC. Since then there have been significant changes in targeted therapies as well as molecular testing including newly approved ta...
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#1Yun-Sung Lim (Dongguk University)H-Index: 1
#2Yoon Se Lee (UOU: University of Ulsan)H-Index: 8
Last. Byung-Joo Lee (PNU: Pusan National University)H-Index: 19
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BACKGROUND/AIM The association between preoperative ultrasound (US) echogenicity and histopathological characteristics of papillary thyroid cancer (PTC) has been rarely investigated is not well characterized. This study evaluated a relationship between the clinical characteristics of PTC, histopathological phenomena including tumor growth patterns (TGPs) and tumor fibrosis (TF), and US echogenicity. PATIENTS AND METHODS In total, 170 patients with PTC (<2 cm) underwent total thyroidectomy with c...
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#1Hong-Min Ahn (PNU: Pusan National University)H-Index: 1
#2Gyung Mo Son (PNU: Pusan National University)H-Index: 13
Last. Hyung Wook Kim (PNU: Pusan National University)H-Index: 20
view all 7 authors...
BACKGROUND Indocyanine green (ICG) is a multifunctional dye used in tumor localization, tissue perfusion, and lymph node (LN) mapping during fluorescence-guided laparoscopic colorectal surgery. PURPOSE This study aimed to establish the optimal protocol for preoperative endoscopic submucosal ICG injection to perform fluorescence lymph node mapping (FLNM), along with undisturbed fluorescent tumor localization and ICG angiography during a single surgery. METHODS Colorectal cancer patients (n = 192)...
1 CitationsSource
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#1Hyun Jung Lee (PNU: Pusan National University)H-Index: 9
#2Dong Hoon Shin (PNU: Pusan National University)H-Index: 17
Last. Jong Kil Nam (PNU: Pusan National University)H-Index: 7
view all 9 authors...
The presence of histologically different neoplasms in the same organ is rare in pathologic practice. We report the first case of synchronous clear cell renal cell carcinoma (clear cell RCC) and papillary renal neoplasm with reverse polarity (PRNRP) with comprehensive immunohistochemical and molecular characterization using next-generation sequencing (NGS). A 61-year-old man was incidentally found to have a left renal mass on imaging studies performed for workup of left back pain and urine color ...
1 CitationsSource
#1Dongwook KimH-Index: 1
#2Hae-Young KimH-Index: 1
Last. Dong-Hoon ShinH-Index: 1
view all 4 authors...
Oncolytic viruses have become a novel therapeutic tool for various cancer treatments. Several naturally occurring oncolytic viruses and engineered oncolytic viruses are developed for oncolytic virotherapies. Although we have a good understanding on molecular mechanisms of viral replication and virus-induced cell lysis at the cellular level, it is unclear how oncolytic viruses and cancer cells interact as a population. Several mathematical models of oncolytic virotherapy have been developed to ad...
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