Hirokazu Tsukahara
Okayama University
ExcretionInternal medicineUrologyEndocrinologySurgeryPathologyRenal functionChemistryPediatricsImmunologyOxidative stressNitriteEncephalopathyUrineKidneyPhysiologyNitric oxideMedicineUrinary systemBiologyGastroenterology
290Publications
39H-index
5,480Citations
Publications 297
Newest
#1Akihito TakeuchiH-Index: 8
#2Takahiro Namba (Okayama University)
Last. Takashi Yorifuji (Okayama University)H-Index: 30
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Background null Previous studies showed that preterm birth increased the risk for hospital admissions in infancy and childhood due to some acute diseases. However, the risk of preterm children developing Kawasaki disease remains unknown. In the present study, we investigate whether preterm birth increased the morbidity of Kawasaki disease. null Methods null We included 36,885 (34,880 term and 2005 preterm) children born in 2010 in Japan. We examined the association between preterm birth and hosp...
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#1Akihiko TaniguchiH-Index: 10
#2Mitsuru TsugeH-Index: 10
Last. Hirokazu TsukaharaH-Index: 39
view all 4 authors...
The respiratory system is continuously exposed to endogenous and exogenous oxidants. Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation of the airways, leading to the destruction of lung parenchyma (emphysema) and declining pulmonary function. It is increasingly obvious that reactive oxygen species (ROS) and reactive nitrogen species (RNS) contribute to the progression and amplification of the inflammatory responses related to this disease. First, we described ...
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#1Mitsuru Tsuge (Okayama University)H-Index: 10
#2Masanori IkedaH-Index: 28
Last. Hirokazu Tsukahara (Okayama University)H-Index: 39
view all 5 authors...
Background Jellyfish stings are known to induce allergic skin reactions; however, case reports of anaphylaxis after jellyfish ingestion have been increasing, especially in Asian countries. Some cases of anaphylaxis after jellyfish ingestion have been reported in patients with a previous history of frequent jellyfish stings. Herein, we report a pediatric patient with anaphylaxis after jellyfish ingestion with no history of jellyfish stings. Case presentation A 14-year-old girl developed two episo...
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#1Kazuhiro Uda (Okayama University)
#2Mitsuru Tsuge (Okayama University)H-Index: 10
Last. Hirokazu Tsukahara (Okayama University)H-Index: 39
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A 33-day-old baby girl was brought with concerns regarding acholic stool colour. After laboratory examinations, abdominal ultrasound and hepatobiliary scintigraphy, biliary atresia was suspected, and the patient was transferred to our hospital for surgery. Biliary atresia was definitively diagnosed by cholangiogram, and the Kasai procedure was performed at 47 days of age, but her jaundice persisted. Her liver condition progressed to cirrhosis requiring liver transplantation. At 5 …
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#1Naomi MatsumotoH-Index: 1
Last. Takashi YorifujiH-Index: 30
view all 4 authors...
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#1Takahiro Namba (Okayama University)
#2Mitsuru Tsuge (Okayama University)H-Index: 10
Last. Hirokazu Tsukahara (Okayama University)H-Index: 39
view all 8 authors...
Objective High mobility group box-1 (HMGB1) has been reported to be involved in influenza A virus-induced acute respiratory distress syndrome (ARDS). We studied the efficacy of an anti-HMGB1 mAb using an in vitro model of TNF-α stimulation or influenza A virus infection in human pulmonary microvascular endothelial cells (HMVECs). null Methods Vascular permeability of HMVECs was quantified using the Boyden chamber assay under tumor necrosis factor-α (TNF-α) stimulation or influenza A virus infect...
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#1Kosei Hasegawa (Okayama University)H-Index: 10
#2Hiroyuki Tanaka (Okayama University)H-Index: 43
Last. Hirokazu Tsukahara (Okayama University)H-Index: 39
view all 6 authors...
Pathogenic-activating variants of interferon induced with Helicase C domain 1 (IFIH1) cause Singleton-Merten (S-M) syndrome, which accompanies acro-osteolysis, loss of permanent teeth, and aortic calcification, as well as causing Aicardi-Goutieres (A-G) syndrome, which shows progressive encephalopathy, spastic paraplegia, and calcification of basal ganglia. Recently, patients with overlapping syndromes presenting with features of S-M syndrome and A-G syndrome were reported. However, progression ...
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#1Tomoka OkamuraH-Index: 2
#2Yosuke WashioH-Index: 5
Last. Satoshi KusudaH-Index: 24
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Late-onset circulatory collapse (LCC) in preterm infants is presumably caused by relative adrenal insufficiency. Because eosinophilia is known to be associated with adrenal insufficiency, we attempted to clarify the relation-ship between eosinophilia and LCC in preterm infants. We divided the cases of the infants (born at < 28 weeks’ gestation) admitted to our neonatal intensive care unit in 2008-2010 into 2 groups: those diagnosed with LCC that received glucocorticoids (LCC group), and those wh...
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#1Yousuke Higuchi (Okayama University)H-Index: 6
#2Kosei Hasegawa (Okayama University)H-Index: 10
Last. Hirokazu Tsukahara (Okayama University)H-Index: 39
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BACKGROUND Osteogenesis imperfecta (OI) is a rare connective-tissue disorder characterized by bone fragility. Approximately 90% of all OI cases are caused by variants in COL1A1 or COL1A2. Additionally, IFITM5 variants are responsible for the unique OI type 5. We previously analyzed COL1A1/2 variants in 22 Japanese families with OI through denaturing high-performance liquid chromatography screening, but our detection rate was low (41%). METHODS To expand the genotype-phenotype correlations, we pe...
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#1Hirokazu Tsukahara (Okayama University)H-Index: 39
#2Tsukasa Higashionna (Okayama University)H-Index: 1
Last. Nobuchika Kusano (Okayama University)H-Index: 16
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In Japan, clinical and experimental studies addressing COVID-19 have been increasing in number since early February 2020, with many case reports being published. Concurrently, many notifications and guidelines have been issued from the government and academic societies. Taking optimal measures at the prefectural level as well as the national level is necessary to prevent the spread of COVID-19. Surveying and analyzing details of the incidences of infected persons in each prefecture is extremely ...
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