Christian Gille
Boston Children's Hospital
Internal medicineInnate immune systemPeripheral blood mononuclear cellPhagocytosisProinflammatory cytokineTumor necrosis factor alphaChemistryPediatricsApoptosisImmunologyT cellInflammationGestational ageSepsisPregnancyCord bloodMonocyteProgrammed cell deathMyeloid-derived Suppressor CellBirth weightMedicineBiologyImmune systemCell biology
75Publications
17H-index
884Citations
Publications 76
Newest
#1Stefanie DietzH-Index: 3
#2Julian SchwarzH-Index: 6
Last. Natascha Köstlin-GilleH-Index: 4
view all 10 authors...
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#1Stefanie Dietz (Boston Children's Hospital)H-Index: 3
#2Julian Schwarz (Boston Children's Hospital)H-Index: 6
Last. Natascha Köstlin-Gille (Boston Children's Hospital)H-Index: 4
view all 11 authors...
Abstract Immunological pregnancy complications are a main challenge in reproductive medicine. Mechanisms regulating the adaptation of the maternal immune system to pregnancy are incompletely understood and therapeutic options limited. Myeloid derived suppressor cells (MDSC) are immune-modulatory cells expanding during healthy pregnancy and seem to play a crucial role for maternal-fetal tolerance. Recent studies showed that exosomes produced by MDSC have immune-modulatory effects corresponding to...
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#1Natascha Köstlin-Gille (Boston Children's Hospital)H-Index: 4
#2Christoph Härtel (University of Lübeck)H-Index: 33
Last. Christian Gille (Boston Children's Hospital)H-Index: 17
view all 9 authors...
BACKGROUND Sepsis is a major cause of death in neonates. Knowledge about epidemiology, risk factors, causative pathogens and outcome of neonatal sepsis is important to improve neonatal care. For Germany, only few data on neonatal sepsis in very low birth weight (VLBW) infants exist. METHODS Data from 14,926 preterm infants with birth weight <1500 g and gestational age between 22 0/7 weeks and 31 6/7 collected between January 2009 and December 2017 were analyzed for frequency of early-onset sepsi...
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#1Filip Ďurčo (Boston Children's Hospital)H-Index: 1
#2Natascha Köstlin-Gille (Boston Children's Hospital)H-Index: 4
Last. Christian Gille (Boston Children's Hospital)H-Index: 17
view all 4 authors...
BACKGROUND Neonatal sepsis is a leading cause of neonatal morbidity and mortality, associated with immunosuppression. Myeloid-derived suppressor cells (MDSCs) are cells with immunosuppressive activity, present in high amounts in cord blood. Mechanisms regulating MDSC expansion are incompletely understood. Adenosine is a metabolite with immunoregulatory effects that are elevated in cord blood. METHODS Impact of adenosine on peripheral and cord blood mononuclear cells (PBMCs and CBMCs) was analyse...
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#1Natascha Köstlin-Gille (Boston Children's Hospital)H-Index: 4
#2Christian Gille (Boston Children's Hospital)H-Index: 17
During pregnancy, the immune systems of mother and offspring are challenged by their close adjacency to balance tolerance and rejection. After birth the neonate has to continue this balance towards its new environment by tolerating commensals while rejecting pathogens and towards its developing tissues to avoid inflammatory damage while overcoming immunosuppression. Our group was the first to link immunosuppressive features of myeloid derived suppressor cells (MDSC) to materno-fetal tolerance, n...
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#1Christoph HärtelH-Index: 33
#2Kirstin Faust (University of Lübeck)H-Index: 6
Last. Wolfgang Göpel (University of Lübeck)H-Index: 27
view all 20 authors...
In 2013 German infection surveillance guidelines recommended weekly colonization screening for multidrug-resistant (MDRO) or highly epidemic organisms for neonatal intensive care units (NICUs) and extended hygiene measures based on screening results. It remains a matter of debate whether screening is worth the effort. We therefore aimed to evaluate sepsis related outcomes before and after the guideline update. The German Neonatal Network (GNN) is a prospective cohort study including data from ex...
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#2Lara-Antonia FlaigH-Index: 1
Last. Christian GilleH-Index: 17
view all 6 authors...
Background: Infections are the main cause of death in preterm infants. Causative agents often descend from the intestinal flora of the infected neonate, indicating insufficient protection by the mucosal barrier. Breast milk (BM) contains different subsets of immune cells. We recently showed that BM contains significant numbers of myeloid-derived suppressor cells (MDSC)—immune cells that actively suppress pro-inflammatory immune responses—and hypothesized that the transfer of BM-MDSC may modulate...
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#1Christian A. Maiwald (Boston Children's Hospital)H-Index: 3
Last. Christian F. Poets (Boston Children's Hospital)H-Index: 65
view all 6 authors...
BACKGROUND: Respiratory distress syndrome (RDS) is a frequent complication of premature birth. Treating RDS by continuous positive airway pressure and less invasive surfactant administration (LISA) may reduce bronchopulmonary dysplasia. Surfactant, however, can be inactivated by bacterial infection. Therefore, potential routes of microbe transmission into the airway are of interest. The aim of this study was to evaluate microbiological contamination of catheters used for LISA procedures and its ...
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#1Janina Marißen (University of Lübeck)H-Index: 2
#2Annette Haiß (University of Lübeck)H-Index: 11
Last. Christoph Härtel (University of Lübeck)H-Index: 7
view all 22 authors...
Introduction The healthy ‘eubiosis’ microbiome in infancy is regarded as the microbiome derived from term, vaginally delivered, antibiotic free, breastfed infants at 4–6 months. Dysbiosis is regarded as a deviation from a healthy state with reduced microbial diversity and deficient capacity to control drug-resistant organisms. Preterm infants are highly sensitive to early gut dysbiosis. Latter has been associated with sepsis and necrotising enterocolitis, but may also contribute to long-term hea...
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#1Stefan Gottlob (Boston Children's Hospital)H-Index: 1
#2Christian Gille (Boston Children's Hospital)H-Index: 17
Last. Christian F. Poets (Boston Children's Hospital)H-Index: 65
view all 3 authors...
BACKGROUND: Hypoxemia and bradycardia occur frequently in preterm infants, but are incompletely understood. They are more prevalent during infections and following immunization. Data on adults suggested an increased immune response if subjects slept following vaccination, suggesting an interaction between circadian rhythm and the immune system. Whether this holds true for preterm infants with their less well-established circadian rhythm is unclear. OBJECTIVE: Do infants born at 26-30 weeks' gest...
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