Xinxin Zhao
Sichuan Agricultural University
GeneInnate immune systemViral replicationGenomeMutantMolecular biologyVirologyPlasmidVirusFlavivirusRiemerella anatipestiferComputer securityComputer scienceTransfectionGeneticsVirulenceBiologyImmune systemMicrobiologyCell biology
184Publications
18H-index
1,319Citations
Publications 187
Newest
#1Mi Huang (Sichuan Agricultural University)H-Index: 3
#2Mafeng Liu (Sichuan Agricultural University)H-Index: 18
Last. Qun Gao (Sichuan Agricultural University)H-Index: 3
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Abstract null null Bacteria can take up exogenous naked DNA and integrate it into their genomes, which has been regarded as a main contributor to bacterial evolution. The competent status of bacteria is influenced by environmental cues and by the immune systems of bacteria. Here, we review recent advances in understanding the working mechanisms underlying activation of the natural transformation system and limitations thereof. Environmental stresses including the presence of antimicrobials can a...
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#1Shaqiu Zhang (Sichuan Agricultural University)H-Index: 13
#2Muhammad Abbas (Sichuan Agricultural University)H-Index: 1
Last. Qun Gao (Sichuan Agricultural University)H-Index: 3
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Colistin drug resistance is an emerging public health threat worldwide. The adaptability, existence and spread of colistin drug resistance in multiple reservoirs and ecological environmental settings is significantly increasing the rate of occurrence of multidrug resistant (MDR) bacteria such as Escherichia coli (E. coli). Here, we summarized the reports regarding molecular and biological characterization of mobile colistin resistance gene (mcr)-positive E. coli (MCRPEC), originating from divers...
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#1Zhishuang Yang (Sichuan Agricultural University)H-Index: 2
#2Xue-Qin Yang (Sichuan Agricultural University)H-Index: 1
Last. Shaqiu Zhang (Sichuan Agricultural University)H-Index: 13
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The disease caused by Riemerella anatipestifer (R. anatipestifer) causes large economic losses to the global duck industry every year. Serotype-related genomic variation (such as in O-antigen and capsular polysaccharide gene clusters) has been widely used for the serotyping in many gram-negative bacteria. To date, there have been few studies focused on genetic basis of serotypes in R. anatipestifer. Here, we used pan-genome-wide association studies (Pan-GWAS) to identify the serotype-specific ge...
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#1Shaqiu Zhang (Sichuan Agricultural University)H-Index: 13
#2Shuling Chen (Sichuan Agricultural University)H-Index: 2
Last. Ying Wu (Sichuan Agricultural University)H-Index: 17
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Harmonious ecological environment is a major concern with rising feeding and consumption of ducks, as these waterfowl birds can promote the spread of antibiotic resistant genes (ARGs). Therefore, this study was conducted to know diversity of antimicrobial resistance (AMR), integrons, and mobile genetic elements (MGEs) in Escherichia coli (E. coli) isolated from intestinal contents or pericardial effusion of diseased ducks from 2018 to 2020 in Sichuan, China. The AMR phenotype was determined via ...
1 CitationsSource
#1Zezheng Liu (Sichuan Agricultural University)
#2Qian Ye (Sichuan Agricultural University)
Last. Ying Wu (Sichuan Agricultural University)H-Index: 17
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ABSTRACT null null Duck hepatitis A virus 1 (DHAV-1) can cause high morbidity and fatal acute infectious hepatitis in ducklings, which seriously endangers animal husbandry. Viroporin is a small molecular weight hydrophobic transmembrane protein encoded by the virus, that has been suggested to induce autophagy in host cells by increasing the membrane permeability through disturbing the ion balance. In this study, we aimed to investigate whether the DHAV-1 2B protein can induce autophagy in DEF ce...
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#1Shaqiu Zhang (Sichuan Agricultural University)H-Index: 13
#2Shuling Chen (Sichuan Agricultural University)H-Index: 2
Last. Anchun Cheng (Sichuan Agricultural University)H-Index: 29
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Abstract There are rising concerns about microbes harboring antibiotic resistance genes (ARGs) and virulence-associated genes (VAGs) in humans and food-producing animals. Moreover, ARGs are considered as emerging environmental pollutants, posing probable life-threatening complications in humans and animals. Commensal Escherichia coli (E. coli) strain can carry a large number of VAGs, which may become opportunistic pathogen. The objective of this study was to determine the prevalence and possible...
1 CitationsSource
#1Wei Zhang (Sichuan Agricultural University)H-Index: 10
#2Miao Zeng (Sichuan Agricultural University)H-Index: 3
Last. Shun Chen (Sichuan Agricultural University)H-Index: 20
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Our previous studies reported that duck Tembusu virus (DTMUV) nonstructural protein 2A (NS2A) is a major inhibitor of the IFNβ signaling pathway through competitively binding to STING with TBK1, leading to a reduction in TBK1 phosphorylation (Zhang, et al., J. Virol. 2020). DTMUV NS2B3 could cleave and bind STING to subvert the IFNβ signaling pathway (Wu, et al., J. Immunol. 2019). Here, we found that DTMUV NS4B competitively bound to STING with TBK1, reducing TBK1 phosphorylation and inhibiting...
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#1Mafeng Liu (Sichuan Agricultural University)H-Index: 18
#2Siqi Liu (Sichuan Agricultural University)
Last. Anchun Cheng (Sichuan Agricultural University)H-Index: 29
view all 23 authors...
Iron is an essential element for the replication of most bacteria, including Riemerella anatipestifer (R. anatipestifer, RA), a gram-negative bacterial pathogen of ducks and other birds. R. anatipestifer utilizes haemoglobin-derived haemin as an iron source; however, the mechanism by which this bacterium acquires haemin from haemoglobin is largely unknown. Here, RhuA disruption was shown to impair iron utilization from duck haemoglobin in R. anatipestifer CH-1. Moreover, the putative lipoprotein...
1 CitationsSource
#1Zhen Wu (Sichuan Agricultural University)H-Index: 6
#1Wu Zhen (Sichuan Agricultural University)
Last. Anchun Cheng (Sichuan Agricultural University)H-Index: 29
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Abstract Previously, we isolated a novel strain of goose pegivirus (GPgV) that infects geese and shows high levels of lymphotropism. This novel pegivirus strain is phylogenetically distinct from previously known Pegivirus species, Pegivirus A-K, and qualifies as a candidate new Pegivirus species, GPgV. GPgV is tentatively named Pegivirus M. Here, to better understand the epidemic of GPgV infection and the co-infection of this virus with other viruses in Southwest China, 25 geese in poor health f...
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#1Xumin Ou (Sichuan Agricultural University)H-Index: 4
#1Xumin Ou (Sichuan Agricultural University)H-Index: 8
Last. Anchun Cheng (Sichuan Agricultural University)H-Index: 29
view all 19 authors...
Highly pathogenic coronaviruses, including SARS-CoV-2, SARS-CoV, and MERS-CoV, are thought to be transmitted from bats to humans, but the viral genetic signatures that contribute to bat-to-human transmission remain largely obscure. In this study, we identified an identical ribosomal frameshift motif among the three bat-human pairs of viruses and strong purifying selection after jumping from bats to humans. This represents genetic signatures of coronaviruses that are related to bat-to-human trans...
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