Qi Shen
Shanghai Jiao Tong University
CytotoxicityPharmacokineticsBiophysicsAbsorption (skin)NanoparticleBioavailabilityChemistryIn vitroIn vivoTumor microenvironmentOral administrationMetastasisDrug deliveryPLGADaidzeinDoxorubicinIntestinal absorptionChromatographyCancer researchZeta potentialPharmacology
47Publications
18H-index
959Citations
Publications 47
Newest
#1Hajra Zafar (SJTU: Shanghai Jiao Tong University)H-Index: 3
#2Faisal Raza (SJTU: Shanghai Jiao Tong University)H-Index: 10
Last. Qi Shen (SJTU: Shanghai Jiao Tong University)H-Index: 18
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The current treatment strategies for cancer therapy have posed many problems in achieving high efficacy. Therefore, an urgent step is needed to develop innovative therapies that can win beyond satisfactory results against tumor. Ferroptosis that is a kind of non-apoptotic based programmed cell death has played a crucial role in eradicating tumors by reactive oxygen species and iron-dependent pathways. Research shows a remarkable potential of ferroptosis in eliminating aggressive malignancies res...
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#1Jie Yang (SJTU: Shanghai Jiao Tong University)H-Index: 1
#1Jie Yang (SJTU: Shanghai Jiao Tong University)H-Index: 116
Last. Qi Shen (SJTU: Shanghai Jiao Tong University)H-Index: 18
view all 10 authors...
Antitumor immunotherapy is limited by low tumor immunogenicity and immunosuppressive microenvironment (TIME), which could be improved by "ROS-ferroptosis-glycolysis regulation" strategy. Herein, a cancer cell membrane coated metal organic framework (MOF) loading with glucose oxidase (GOx) and doxorubicin (DOX) was constructed (denoted as mFe(SS)/DG). Benefiting from the homotypic targeting of cancer cell membrane, the nanoplatform effectively accumulated in tumors. mFe(SS)/DG based on coordinati...
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Abstract null null Triple negative breast cancer (TNBC) metastasis is still one of the obstacles in clinical treatment, while highly-effective cancer drugs usually cannot be used for their hydrophobicity and comprehensive system toxicity. This study built a kind of pH-sensitive nanoparticles (PP/H NPs) constructed by poly (lactic-co-glycolic acid) modified with β-cyclodextrin (PLGA-β-CD), polyethyleneimine grafted with benzimidazole (PEI-BM) and low molecular weight heparin (LMWH) to delivery Ce...
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#1Huizi Deng (SJTU: Shanghai Jiao Tong University)
#2Yifan Yang (SJTU: Shanghai Jiao Tong University)H-Index: 4
Last. Qi Shen (SJTU: Shanghai Jiao Tong University)H-Index: 18
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Abstract The poor drug delivery and unsatisfying therapeutic effects remain to be the primary challenges for cancer therapy. Nanosystem that combines multiple functions into a single platform is an ideal strategy. Here, a smart drug delivery nanoplatform (Z@C-D/P) based on ZnO@CuS nanoparticles, loaded with doxorubicin (DOX) and pirfenidone (PFD) was constructed. Importantly, the β-CD-DMA and PEG-DMA could be activated in the mild acidic tumor microenvironment, then the nanosystem underwent char...
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#1Tiantian ZuoH-Index: 5
#2Jun Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 119
Last. Qi ShenH-Index: 18
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The desmoplastic tumor microenvironment (DTME), including overexpressed stromal cells and extracellular matrix, formed the first barrier for the accumulation and penetration of nanoparticles in tumors, which compromised the therapeutic efficacy and prognosis. In some metastatic cells, overactivity of the tricarboxylic cycle could overload the electron transport chain resulting in increased mtROS production, which triggered the mitochondria-driven tumor migration and metastasis. Hence, we develop...
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#1Rui Xu (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Jie Yang (SJTU: Shanghai Jiao Tong University)H-Index: 116
Last. Qi Shen (SJTU: Shanghai Jiao Tong University)H-Index: 18
view all 9 authors...
Non-apoptotic cell death such as ferroptosis and pyroptosis has shed new light on cancer treatment, whereas combinational therapy using both these mechanisms has not yet been fully explored. Herein, a dual-inductive nano-system to realize ferroptosis/pyroptosis mediated anti-cancer effects is presented. The nanodrug (Tf-LipoMof@PL) is constructed with a piperlongumine (PL) loaded metal-organic framework (MOF) coated with transferrin decorated pH sensitive lipid layer. Intracellular iron was enri...
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#1Zhihua Wang (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Yingxin Xu (SJTU: Shanghai Jiao Tong University)H-Index: 3
Last. Qi Shen (SJTU: Shanghai Jiao Tong University)H-Index: 18
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Tumor microenvironment (TME), with complex composition, plays a vital role in the occurrence, development, and metastasis of tumors. TME becomes an important obstacle to the accessibility of nanotherapy, thus indicating the need to improve the functional design to overcome this challenge. In this study, we generate an intelligent nano-drug-delivery system (DOX@PssP-Hh NPs) with dual environmental response, which involves heparanase (HPSE) in TME and glutathione (GSH) in tumor cells. The nanosyst...
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#1Jun Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 119
#1Jun Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 6
Last. Qi Shen (SJTU: Shanghai Jiao Tong University)H-Index: 18
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The aggressive progression of breast cancer is impacted significantly by the tumor microenvironment (TME). The current chemotherapy normally causes cytotoxicity to tumor cells, while does not effectively modulate the TME. Thus, the chemotherapy effect of breast cancer is usually dissatisfactory. In this study, a kind of hierarchically releasing bio-responsive nanoparticles (R(D)/H(S) NPs), constructed by β-cyclodextrin-grafted heparin and pH-sensitive pseudorotaxane, were investigated to enhance...
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#1Jun Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 119
#1Jun Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 6
Last. Qi Shen (SJTU: Shanghai Jiao Tong University)H-Index: 18
view all 10 authors...
Abstract The normal chemotherapy only induces the intracellular apoptosis pathway to promote primary tumor cells death, while not inhibit tumor metastasis. Herein, we proposed a kind of heparanase (HPSE)-driven sequential released nanoparticles, which modified with β-cyclodextrin (β-CD) grafted heparin (NLC/H(D + F + S) NPs) co-loading with doxorubicin (DOX), ferrocene (Fc), and TGF-β receptor inhibitor (SB431542). NLC/H(D + F + S) NPs successfully inhibited breast cancer metastasis by intracell...
2 CitationsSource
#1Tianxu Fang (SJTU: Shanghai Jiao Tong University)H-Index: 3
#2Jun Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 119
Last. Qi Shen (SJTU: Shanghai Jiao Tong University)H-Index: 18
view all 8 authors...
Extracellular matrix (ECM) accumulating in tumor microenvironment (TME) is generated by tumor associated fibroblasts. It can elevate interstitial fluid pressure and form dense barriers in tumor tissues. Consequently, nanocarriers are hindered from permeating into deeper tumor sites. Thus, the programmed drug releasing nanoparticles, G(TM)PPSP, were developed for TME remodeling and breast cancer therapy. Gelatin nanoparticles were linked with platinum nanoparticles (PtNPs) to obtain G(TM)PPSP wit...
4 CitationsSource