Yu Yamamoto
GeneEnhancerBiophysicsEmbryonic stem cellCellular differentiationGene expressionMolecular biologyMetal ions in aqueous solutionHomeobox protein NANOGRegulatory sequenceTranscriptional regulationCruciformSOX2NucleusSuper-enhancerTranscription (biology)MetalMicroinjectionBiologyCell biology
Publications 3
DNA can adopt various structures besides the B-form. Among them, cruciform structures are formed on inverted repeat (IR) sequences. While cruciform formable IRs (CFIRs) are sometimes found in regulatory regions of transcription, their function in transcription remains elusive, especially in eukaryotes. We found a cluster of CFIRs within the mouse Pou5f1 enhancer. Here, we demonstrate that this cluster or some member(s) plays an active role in the transcriptional regulation of not only Pou5f1, bu...