Miao Wang
Shenyang Pharmaceutical University
Therapeutic effectPharmacokineticsChemical compositionMass spectrometryFourier transform ion cyclotron resonanceCarbohydrate metabolismHigh-performance liquid chromatographyChemistryDecoctionMetabolic pathwayRadixIn vivoMetabolomicsFormic acidAtorvastatinGynostemma pentaphyllumFatty liverHyperlipidemiaChemical constituentsChromatographyLipid metabolismPharmacology
32Publications
9H-index
184Citations
Publications 32
Newest
#1Zhibo Guan (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 6 authors...
Abstract Sijunzi decoction, a renowned Chinese prescription has long been utilized to treat gastrointestinal problems. In the context of this research work, the use of Ultra high performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry was made to separate and characterize the components of Sijunzi decoction. The performance of Liquid chromatography was carried out on a C8 column (150 mm × 2.1 mm, 1.8 μm); moreover, the mobile phase were consist...
10 CitationsSource
#1Zhibo Guan (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Juan Wu (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 8 authors...
Abstract Ethnopharmacological relevance Sijunzi decoction (SJZD) is a well known traditional Chinese prescription used for the treatment of gastrointestinal disorders and immunity enhancement. It has been found to indeed improve life quality of chemotherapy patients and extensive used in clinical conbined with chemotherapeutics for the treatment of cancer. Aim of the study The aim of this study was to investigate the preventive effect of the immunotoxicity of SJZD on mitomycin C (MMC) and the me...
13 CitationsSource
#1Yinan Wang (SPU: Shenyang Pharmaceutical University)H-Index: 7
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 7 authors...
Cortex Fraxini is an important traditional Chinese herbal medicine used for the treatment of gout and hyperuricemia. An efficient and rapid ultra-performance liquid chromatography mass spectrometry method was developed and validated for simultaneous quantitation of six coumarins (aesculin, fraxin, aesculetin, fraxetin, sopoletin and 7-hydroxycoumarin) in normal and hyperuricemic rats plasma after oral administration of Cortex Fraxini. The method could successfully be applied for pharmacokinetics...
6 CitationsSource
#1Yinan Wang (SPU: Shenyang Pharmaceutical University)H-Index: 7
#2Fei Han (SPU: Shenyang Pharmaceutical University)H-Index: 17
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 5
view all 6 authors...
Cortex Fraxini is an important traditional Chinese medicine. In this work, a rapid and reliable homogenate extraction method was applied for the fast extraction for Cortex Fraxini, and the method was optimized by response surface methodology. Ultra high performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry and gas chromatography with mass spectrometry were established for the separation and characterization of the constituents of Cortex Fraxi...
6 CitationsSource
#1Yinan Wang (SPU: Shenyang Pharmaceutical University)H-Index: 7
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 6 authors...
Abstract Ethnopharmacological relevance Cortex Fraxini (CF) is an important traditional Chinese herbal medicine used for the treatment of gout and hyperuricemia. Aim of the study The aim of this study was to evaluate the anti-hyperuricemic effect of CF on hyperuricemic rats and to investigate its mechanism of action. Materials and methods Metabolomics based on NMR and MS was used to study the therapeutic effect of CF on hyperuricemic rats. Plasma determination of uric acid (UA) showed that CF tr...
21 CitationsSource
#1Yinan Wang (SPU: Shenyang Pharmaceutical University)H-Index: 7
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 5
view all 7 authors...
Abstract Esculin, a coumarin derivative found in Fraxinus rhynchophylla , has been reported to possess multiple biological activities. This present study is designed to investigate the metabolic profile of esculin in vivo based on ultra high performance liquid chromatography coupled to Fourier transform ion cyclotron resonance mass spectrometry (UHPLC-FT-ICR-MS) for the first time. After oral administration of esculin (100 mg/kg) for rats, plasma, urine, feces and bile samples were collected to ...
19 CitationsSource
#1Yinan Wang (SPU: Shenyang Pharmaceutical University)H-Index: 7
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 5 authors...
Cortex Fraxini is a widely used traditional Chinese medicine (TCM) used for the treatment of gout or hyperuricemia. In this study, a reliable and sensitive ultra-high performance liquid chromatography coupled with Fourier transform ion cyclotron resonance mass spectrometry (UHPLC-FT-ICR-MS) method was developed for systematical screen and identification of the metabolic profile in rats after oral administration of Cortex Fraxini. The chromatographic separation was performed on a Universil XB C18...
10 CitationsSource
#1Yinan Wang (SPU: Shenyang Pharmaceutical University)H-Index: 7
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 5
view all 4 authors...
AbstractContext Gynostemma pentaphyllum (Thunb.) Makino has been used in traditional medicine for the treatment of hyperlipidaemic with a long history.Objective: The objective of this study was to evaluate the influence of Gynostemma pentaphyllum (GP) and atorvastatin on amino acids from the plasma and liver tissue of hyperlipidaemic rats.Materials and methods The rats were fed a high-fat diet continuously for 11 weeks for the construction of hyperlipidaemic model. The hyperlipidaemic rats were ...
6 CitationsSource
#1Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
#2Yinan Wang (SPU: Shenyang Pharmaceutical University)H-Index: 7
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 5 authors...
Gynostemma pentaphyllum (GP) is widely used for the treatment of diseases such as hyperlipidemia, fatty liver and obesity in China, and atorvastatin is a popular anti-hyperlipidemia drug. Based on GC/MS and metabonomic methods, this study focuses on the comparative metabolic profiling analysis of fatty acids in the plasma and liver of hyperlipidemic rats before and after treatment, in order to identify the treatment mechanism of the two drugs. Results obtained show that GP and atorvastatin can e...
12 CitationsSource
#1Min Feng (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 6 authors...
The total alkaloids extracted from Rauvolfia verticillata have been developed into drugs-Verticil to treat hypertension. It has a slow and sustained reduction in blood pressure, for the treatment of early and mild hypertension. Ajmalicine, an indole alkaloid from total alkaloids, has been shown to not only reduce blood pressure but also expand blood vessels. However, the mechanism of the antihypertensive effect of total alkaloids and ajmalicine has not been fully characterized. In this research,...
7 CitationsSource