Interstitial lung diseases (ILDs) in patients with shortened telomeres have not been well characterized. We describe demographic, radiologic, histopathologic, and molecular features, and p16 expression in patients with telomeres ≤10th percentile (shortened telomeres) and compare them to patients with telomere length >10th percentile. Lung explants, wedge biopsies, and autopsy specimens of patients with telomere testing were reviewed independently by 3 pathologists using defined parameters. High-...
Purpose Explanted lungs are histopathologically reviewed to confirm or establish the diagnosis of the underlying lung disease and to identify other potentially important findings such as acute lung injury or malignancy. Currently there are no guidelines to direct explant sampling. We aimed to identify optimal lung explant specimen sampling and to better understand how additional pathologic findings may impact outcome of patients. Methods All explants (1/2009-1/2019) were initially sampled (“rout...
B-cell activation is increasingly linked to numerous fibrotic lung diseases and it is well-known that aggregates of lymphocytes form in the lung of many of these patients (1, 2). Activation of B-cells by pattern recognition receptors (PRR) drives the release of inflammatory cytokines, chemokines and metalloproteases important in the pathophysiology of pulmonary fibrosis (3-6). However, the specific mechanisms of B-cell activation in patients with idiopathic pulmonary fibrosis (IPF) are poorly un...
Abstract Background Exogenous lipoid pneumonia (ELP) develops when lipid-containing substances enter the airways through aspiration or inhalation, and incite an inflammatory response. The diagnosis of ELP is often difficult as findings may be nonspecific. ELP’s clinical course has not been well-characterized. Research Question What are the presenting clinico-radiologic features of ELP, its causative agents, and clinical course? Study Design and Methods We searched the Mayo Clinic electronic medi...
Abstract Background Intrathoracic involvement with lymphomas is common and manifests lymphadenopathy as well as a wide spectrum of imaging abnormalities in the lungs. Intravascular large B-cell lymphoma (IVLBCL) is a rare extranodal subtype of large B-cell lymphoma that typically involves small blood vessels and is difficult to detect. Methods Using a computer-assisted search, we identified patients with histopathologically proven IVLBCL in the lungs at Mayo Clinic from 2001 through 2018. Medica...
Abstract Background Primary Sjogren's Syndrome (pSS) is characterized by an immune-mediated lymphoplasmacytic infiltration of the salivary and lacrimal glands. Pulmonary nodules are not uncommonly encountered in these patients. Methods We conducted a retrospective computer-assisted search for patients with pSS who were encountered at our institution between 1999 and 2018 and had histologically characterized pulmonary nodule(s)/mass (es) (PNs). Results Of 41 patients with pSS and PNs, median age ...
Last. Andrew Churg(UBC: University of British Columbia)H-Index: 72
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Common variable immunodeficiency (CVID) and selective immunoglobulin A deficiency (IgAD) often cause chronic lung disease, but the pulmonary pathologic features of these systemic diseases are poorly recognized by pathologists. It has been claimed that CVID cases show a characteristic combination of noncaseating granulomas-lymphoid proliferations termed granulomatous-lymphocytic interstitial lung disease (GLILD). We present 34 surgical lung biopsy cases of CVID and 4 of IgAD. Noncaseating granulo...