Valentina Di Salvatore
University of Catania
GeneCancerPhenotypeImmunologyHeavy metalsMethicillin-resistant Staphylococcus aureusKrameria lappaceaMalignancyThyroid cancerStem cellOccupational exposureThyroid carcinomaEpigeneticsMAP3K8Endocrine systemMutationCancer researchComputational biologyMedicineBiologyImmune systemMicrobiology
12Publications
3H-index
68Citations
Publications 11
Newest
#1Carlo Genovese (University of Catania)H-Index: 12
#2Floriana D’Angeli (University of Catania)H-Index: 6
Last. Debora Lo Furno (University of Catania)H-Index: 14
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#1Giulia Russo (University of Catania)H-Index: 27
#2Valentina Di Salvatore (University of Catania)H-Index: 3
Last. Francesco Pappalardo (University of Catania)H-Index: 23
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#1Carlo GenoveseH-Index: 12
Last. Giovanni Li VoltiH-Index: 46
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Methicillin-resistant Staphylococcus aureus (MRSA) represents a serious threat to public health, due to its large variety of pathogenetic mechanisms. Accordingly, the present study aimed to investigate the anti-MRSA activities of Krameria lappacea, a medicinal plant native to South America. Through Ultra-High-Performance Liquid Chromatography coupled with High-Resolution Mass spectrometry, we analyzed the chemical composition of Krameria lappacea root extract (KLRE). The antibacterial activity o...
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#1Valentina Di Salvatore (University of Catania)H-Index: 3
#2Daniela Formica (University of Catania)
Last. Francesco Pappalardo (University of Catania)H-Index: 23
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One of the main problems in the fight against cancer is represented by the immunosuppression it causes. Several research lines have been undertaken to address this issue; one of the most promising is represented by oncolytic viruses. Oncolytic viruses are designed from live attenuated recombinant viruses and are designed to preferentially infect cancer cells, within which they replicate causing their lysis and enhance, through various mechanisms, innate and adaptive immunity. In collaboration wi...
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#1Carlo Genovese (University of Catania)H-Index: 12
#2Floriana D’Angeli (University of Catania)H-Index: 6
Last. Daria Nicolosi (University of Catania)H-Index: 13
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Streptococcus agalactiae (also known Group B Streptococcus or GBS) represents the main pathogen responsible for early- and late-onset infections in newborns. The present study aimed to determine the antimicrobial susceptibility pattern and the capsular serotypes of GBS isolated in Eastern Sicily over 5 years, from January 2015 to December 2019. A total of 3494 GBS were isolated from vaginal swabs of pregnant women (37–39 weeks), as recommended by the Centers for Disease Control and Prevention. C...
2 CitationsSource
#1A. Stivala (University of Catania)H-Index: 8
#2Carlo Genovese (University of Catania)H-Index: 12
Last. Mario Salmeri (University of Catania)H-Index: 13
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Chlamydophila pneumoniae is an intracellular pathogen responsible for respiratory tract infections. The isolation of the microorganism from clinical specimens is essential for a diagnosis. However, the identification of C. pneumoniae by cell cultures is very difficult besides strongly depending on the sample conditions. The study aimed to investigate, in adult patients with pharyngotonsillitis, the frequency of Chlamydophila pneumoniae detection by cell cultures and three conventional PCRs (a co...
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#1Valentina Di Salvatore (University of Catania)H-Index: 3
#1Valentina Di Salvatore (University of Catania)H-Index: 1
Last. Francesco Pappalardo (University of Catania)H-Index: 5
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Thyroid cancer is the commonest endocrine malignancy. Mutation in the BRAF serine/threonine kinase is the most frequent genetic alteration in thyroid cancer. Target therapy for advanced and poorly differentiated thyroid carcinomas include BRAF pathway inhibitors. Here, we evaluated the role of MAP3K8 expression as a potential driver of resistance to BRAF inhibition in thyroid cancer. By analyzing Gene Expression Omnibus data repository, across all thyroid cancer histotypes, we found that MAP3K8 ...
#1Saverio Candido (University of Catania)H-Index: 28
#2Giuseppe Alessandro Parasiliti Palumbo (University of Catania)H-Index: 2
Last. Francesco Pappalardo (University of Catania)H-Index: 3
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Background DNA methylation is an epigenetic mechanism of genomic regulation involved in the maintenance of homeostatic balance. Dysregulation of DNA methylation status is one of the driver alterations occurring in neoplastic transformation and cancer progression. The identification of methylation hotspots associated to gene dysregulation may contribute to discover new prognostic and diagnostic biomarkers, as well as, new therapeutic targets.
2 CitationsSource
#1Rossella Salemi (University of Catania)H-Index: 10
#2Andrea Marconi (University of Catania)H-Index: 11
Last. Massimo Libra (University of Catania)H-Index: 66
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: The chronic occupational exposure to contaminants and carcinogens leads to the development of cancer. Over the past decades, many carcinogens have been found in the occupational environment and their presence is often associated with an increased incidence of cancer. According to the International Agency for Research on Cancer (IARC), the majority of carcinogens are classified as 'probable' and 'possible' human carcinogens, while, direct evidence of carcinogenicity is provided in epidemiologic...
9 CitationsSource
#1Concettina Fenga (UNIME: University of Messina)H-Index: 24
#2Silvia Gangemi (UNIME: University of Messina)H-Index: 12
Last. Massimo Libra (University of Catania)H-Index: 66
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It is well-known that occupational and environmental exposure to several factors, including benzene, heavy metals, chemicals and mineral fibers, is associated with the risk of developing a great number of diseases. Numerous studies have been carried out in order to investigate the mechanisms of toxicity of these substances, with particular regard to the possible toxic effects on the immune system. However, little is known about the influence of heavy metals, such as lead, on the immune system in...
33 CitationsSource