Jing Zhang
University of Pennsylvania
Matrix metalloproteinaseInternal medicineDownregulation and upregulationEndocrinologySurgeryPsychologyProinflammatory cytokineNeuroscienceReceptorChemistryImmunologyOxidative stressInflammationAutism spectrum disorderVascular smooth muscleAortaCalcificationAngiotensin IIImmunostainingCancer researchIntellectual disabilitySignal transductionMedicineBiologyCell biology
Publications 71
#1Matúš Vojtek (Edin.: University of Edinburgh)H-Index: 1
#2Jing Zhang (UPenn: University of Pennsylvania)H-Index: 23
Last. Ian Chambers (Edin.: University of Edinburgh)H-Index: 44
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Primordial germ cells (PGCs) are induced in the embryo by signals, including BMP emanating from extra-embryonic ectoderm, that act on cells in the post-implantation epiblast. PGC development can be recapitulated in vitro through the exposure of epiblast-like cells (EpiLCs) to appropriate cytokines, resulting in differentiation into PGC-like cells (PGCLCs). Interestingly, the requirement for cytokines to induce PGCLCs can be bypassed by enforced expression of the transcription factor (TF) NANOG. ...
#1Stacey Elkhatib Smidt (Children's Hospital of Philadelphia)
#2Arpita Ghorai (UPenn: University of Pennsylvania)H-Index: 3
Last. Maja Bucan (UPenn: University of Pennsylvania)H-Index: 42
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#1Xiaoxing Wu (U of C: University of Chicago)H-Index: 6
Last. Wang Ning (U of C: University of Chicago)H-Index: 14
view all 27 authors...
Abstract Intestinal cancers are developed from intestinal epithelial stem cells (ISCs) in intestinal crypts through a multi-step process involved in genetic mutations of oncogenes and tumor suppressor genes. ISCs play a key role in maintaining the homeostasis of gut epithelium. In 2009, Sato et al established a three-dimensional culture system, which mimicked the niche microenvironment by employing the niche factors, and successfully grew crypt ISCs into organoids or Mini-guts in vitro. Since th...
#1Mikhail Pakvasa (U of C: University of Chicago)H-Index: 7
#2Pranav Haravu (U of C: University of Chicago)H-Index: 1
Last. Russell R. Reid (U of C: University of Chicago)H-Index: 35
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Abstract Notch is a cell-cell signaling pathway that is involved in a host of activities including development, oncogenesis, skeletal homeostasis, and much more. More specifically, recent research has demonstrated the importance of Notch signaling in osteogenic differentiation, bone healing, and in the development of the skeleton. The craniofacial skeleton is complex and understanding its development has remained an important focus in biology. In this review we briefly summarize what recent rese...
8 CitationsSource
#1Ling Zhao (CQMU: Chongqing Medical University)H-Index: 9
#2Linjuan Huang (CQMU: Chongqing Medical University)H-Index: 3
Last. Tong-Chuan He (U of C: University of Chicago)H-Index: 90
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Ovarian cancer is one of the most common cancers in women and the second most common cause of gynecologic cancer death in women worldwide. While ovarian cancer is highly heterogeneous in histological subtypes and molecular genetic makeup, epithelial ovarian cancer is the most common subtype. The clinical outcomes of ovarian cancer largely depend on early detection and access to appropriate surgery and systemic therapy. While combination therapy with platinum-based drugs and paclitaxel (PTX) rema...
#1Fang He (U of C: University of Chicago)H-Index: 7
#2Na Ni (U of C: University of Chicago)H-Index: 3
Last. Jiaming Fan (CQMU: Chongqing Medical University)H-Index: 18
view all 35 authors...
RNA interference (RNAi) is mediated by an ∼21-nt double-stranded small interfering RNA (siRNA) and shows great promise in delineating gene functions and in developing therapeutics for human diseases. However, effective gene silencing usually requires the delivery of multiple siRNAs for a given gene, which is often technically challenging and time-consuming. In this study, by exploiting the type IIS restriction endonuclease-based synthetic biology methodology, we developed the fast assembly of mu...
1 CitationsSource
#1Soo Hyuk Kim (NIH: National Institutes of Health)H-Index: 10
#2Lijuan Liu (NIH: National Institutes of Health)H-Index: 4
Last. Mingyi Wang (NIH: National Institutes of Health)H-Index: 28
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Abstract Objective The proinflammatory phenotypic shift of vascular smooth muscle cells (VSMCs) is closely linked to the elastolysis and calcification in the aging arterial wall. Degradation of tropoelastin (TPELN) is a key molecular event which often accompanies the proinflammatory phenotypic shift of VSMCs, arterial elastolysis and calcification with aging. Milk fat globule-EGF factor 8 (MFG-E8), secreted mainly from VSMCs, predominantly binds to degenerated elastin fibers, and alters VSMCs ph...
1 CitationsSource
#1Daigui Cao (CQMU: Chongqing Medical University)H-Index: 9
#2Yan Lei (U of C: University of Chicago)H-Index: 7
Last. Zhan Liao (U of C: University of Chicago)H-Index: 17
view all 22 authors...
Primary bone tumor, also known as osteosarcoma (OS), is the most common primary malignancy of bone in children and young adults. Current treatment protocols yield a 5-year survival rate of near 70% although approximately 80% of patients have metastatic disease at the time of diagnosis. However, long-term survival rates have remained virtually unchanged for nearly four decades, largely due to our limited understanding of the disease process. One major signaling pathway that has been implicated in...
1 Citations
#1Michel Bernier (NIH: National Institutes of Health)H-Index: 49
#2Sarah J. Mitchell (NIH: National Institutes of Health)H-Index: 26
Last. Rafael de Cabo (NIH: National Institutes of Health)H-Index: 94
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Summary Obesity is a top public health concern, and a molecule that safely treats obesity is urgently needed. Disulfiram (known commercially as Antabuse), an FDA-approved treatment for chronic alcohol addiction, exhibits anti-inflammatory properties and helps protect against certain types of cancer. Here, we show that in mice disulfiram treatment prevented body weight gain and abrogated the adverse impact of an obesogenic diet on insulin responsiveness while mitigating liver steatosis and pancre...
9 CitationsSource
#1Wenli Dai (U of C: University of Chicago)H-Index: 3
#2Rangarajan D. Nadadur (U of C: University of Chicago)H-Index: 13
Last. Christopher R. Weber (U of C: University of Chicago)H-Index: 40
view all 22 authors...
Rationale: Zona occludens 1 (ZO-1), encoded by the Tight Junction Protein 1 (TJP1) gene, is a regulator of paracellular permeability in epithelia and endothelia. ZO-1 interacts with the actin cytoskeleton, gap and adherens junction proteins, and localizes to intercalated discs in cardiomyocytes. However, the contribution of ZO-1 to cardiac physiology remains poorly defined. Objective: We aim to determine the role of ZO-1 in cardiac function. Methods and Results: Inducible cardiomyocyte-specific ...
3 CitationsSource