Wolfgang Koenig
Technische Universität München
Genome-wide association studyInternal medicineEndocrinologyCardiologyCohort studyImmunologyHazard ratioType 2 diabetesAcute coronary syndromeHeart failureCoronary artery diseaseDiseaseC-reactive proteinPopulationIn patientMyocardial infarctionGeneticsDiabetes mellitusMedicineCohortBiology
Publications 163
(1) Background: The study aimed to investigate the role of subclinical inflammation on the association between diurnal cortisol patterns and glycaemia in an aged population. (2) Methods: Salivary cortisol, interleukin-6 (IL-6) and glycated haemoglobin (HbA1c) were analysed in a sample of 394 men and 364 women (mean age = 5 ± 6.3, 65–90 years). The ratio of morning after awakening and late-night cortisol was calculated as an indication of diurnal cortisol slope (DCS). Multivariable regression mod...
#1Natalie Arnold (UHH: University of Hamburg)H-Index: 1
#1Natalie ArnoldH-Index: 7
Last. Wolfgang Koenig (TUM: Technische Universität München)H-Index: 34
view all 2 authors...
Improvement in risk prediction of atherosclerotic cardiovascular disease (ASCVD) using information on the genetic predisposition at an individual level might offer new possibilities for the successful management of such complex trait. Latest developments in genetic research with the conduction of genome-wide association studies have facilitated a broader utility of polygenic risk score (PRS) as a potent risk prognosticator, being strongly associated with future cardiovascular events. Although it...
2 CitationsSource
#1Yoichi Imori (Nippon Medical School)H-Index: 7
#2Ken Kato (Chiba University)H-Index: 8
Last. Christian Templin (UZH: University of Zurich)H-Index: 37
view all 124 authors...
BACKGROUND Ethnic disparities have been reported in cardiovascular disease. However, ethnic disparities in takotsubo syndrome (TTS) remain elusive. This study assessed differences in clinical characteristics between Japanese and European TTS patients and determined the impact of ethnicity on in-hospital outcomes. METHODS TTS patients in Japan were enrolled from 10 hospitals and TTS patients in Europe were enrolled from 32 hospitals participating in the International Takotsubo Registry. Clinical ...
#1Seryan Atasoy (TUM: Technische Universität München)H-Index: 1
#1Seryan AtasoyH-Index: 2
Last. Karl-Heinz Ladwig (TUM: Technische Universität München)H-Index: 39
view all 9 authors...
Abstract Objective To investigate the association of generalized anxiety disorder (GAD) symptomology on the incidence of type 2 diabetes. Research design & methods Participants from the prospective KORA F4/FF4 German cohort were followed for a mean of 6.5 years. Generalized Anxiety Disorder scale (GAD-7) was used to assess GAD symptoms and incident type 2 diabetes cases were confirmed using a standard oral glucose tolerance test. Multivariate logistic regression models were used to estimate the ...
#1Júlia Karády (Semmelweis University)H-Index: 11
#2Thomas Mayrhofer (Harvard University)H-Index: 19
Last. Udo Hoffmann (Harvard University)H-Index: 111
view all 11 authors...
Abstract Background High-sensitivity cardiac troponin (hs-cTn) assays have different analytic characteristics. Objectives The goal of this study was to quantify differences between assays for common analytical benchmarks and to determine whether they may result in differences in the management of patients with suspected acute coronary syndrome (ACS). Methods The authors included patients with suspected ACS enrolled in the ROMICAT (Rule Out Myocardial Infarction/Ischemia Using Computer Assisted T...
2 CitationsSource
#1Dora CsengeriH-Index: 1
#1Dora CsengeriH-Index: 1
Last. Renate B. SchnabelH-Index: 70
view all 26 authors...
AIMS There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spectrum of alcohol intake in European cohorts. METHODS AND RESULTS In a community-based pooled cohort, we followed 107 845 individuals for the association between alcohol consumption, including types of alcohol and drinking patterns, and incident AF. We collected...
13 CitationsSource
#1Ken KatoH-Index: 8
#2Victoria L. CammannH-Index: 13
Last. Christian TemplinH-Index: 37
view all 113 authors...
Aims Acute pulmonary disorders are known physical triggers of takotsubo syndrome (TTS). This study aimed to investigate prevalence of acute pulmonary triggers in patients with TTS and their impact on outcomes. Methods and results Patients with TTS were enrolled from the International Takotsubo Registry and screened for triggering factors and comorbidities. Patients were categorized into three groups (acute pulmonary trigger, chronic lung disease, and no lung disease) to compare clinical characte...
1 CitationsSource
#1R. Scott Wright (Mayo Clinic)H-Index: 55
#2Kausik K. Ray (Imperial College London)H-Index: 80
view all 14 authors...
Abstract Background Inclisiran is a double-stranded small interfering RNA that suppresses proprotein convertase subtilisin–kexin type 9 (PCSK9) translation in the liver, leading to sustained reductions in low-density lipoprotein cholesterol (LDL-C) and other atherogenic lipoproteins with twice-yearly dosing. Objectives The purpose of this study was to conduct a patient-level pooled analysis from 3 phase 3 studies of inclisiran. Methods Participants with heterozygous familial hypercholesterolemia...
4 CitationsSource
#1Maria Tomasdottir (Uppsala University)H-Index: 1
#2Claes Held (Uppsala University)H-Index: 67
Last. Ziad Hijazi (Uppsala University)H-Index: 25
view all 20 authors...
Abstract Background In patients with coronary heart disease (CHD), atrial fibrillation (AF) is associated with increased morbidity and mortality. We investigated the associations between clinical risk factors and biomarkers with incident AF in patients with CHD. Methods and Results 13,153 patients with optimally treated CHD included in the STABILITY trial with plasma samples obtained at randomization. Mean follow-up time was 3.5 years. The association between clinical risk factors and biomarkers...
#1Hendrik B. Sager (TUM: Technische Universität München)H-Index: 11
#2Wolfgang Koenig (TUM: Technische Universität München)H-Index: 34
1 CitationsSource