Frederic Fortin
Environmental resource managementPhenotypeGenotypePsychological resilienceAnimal scienceBiotechnologySingle-nucleotide polymorphismAntibodyHeritabilityTranscriptomeAlleleGenetic markerImmunologyVirusComplete blood countNatural (archaeology)Resilience (network)DiseaseNatural antibodyTreatment rateTiterPhysiologyGeneticsBiologyImmune systemEnvironmental health
19Publications
2H-index
38Citations
Publications 21
Newest
BACKGROUND The pork industry faces unprecedented challenges from disease, which increases cost of production and use of antibiotics, and reduces production efficiency, carcass quality, and animal wellbeing. One solution is to improve the overall resilience of pigs to a broad array of common diseases through genetic selection. Behavioral changes in feeding and drinking are usually the very first clinical signs when animals are exposed to stressors such as disease. Changes in feeding and drinking ...
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#2Jian Cheng (Iowa State University)
#4Q Dong (St. Jude Children's Research Hospital)
BACKGROUND Disease resilience, which is the ability of an animal to maintain performance under disease, is important for pigs in commercial herds, where they are exposed to various pathogens. Our objective was to investigate population-level gene expression profiles in the blood of 912 healthy F1 barrows at ~ 27 days of age for associations with performance and health before and after their exposure to a natural polymicrobial disease challenge at ~ 43 days of age. RESULTS Most significant (q < 0...
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Disease resilience refers to productivity of an animal under disease. Given the high biosecurity of pig nucleus herds, traits that can be measured on healthy pigs and that are genetically correlated with disease resilience, i.e. genetic indicator traits, offer a strategy to select for disease resilience. Our objective was to evaluate mitogen stimulation assays on peripheral blood mononuclear cells from young healthy pigs as genetic indicators for disease resilience. Data were from a natural dise...
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#1Xuechun Bai (U of A: University of Alberta)H-Index: 1
#2Tianfu Yang (U of A: University of Alberta)H-Index: 5
Last. Catherine J. Field (U of A: University of Alberta)H-Index: 71
view all 12 authors...
BACKGROUND Genetic improvement for disease resilience is anticipated to be a practical method to improve efficiency and profitability of the pig industry, as resilient pigs maintain a relatively undepressed level of performance in the face of infection. However, multiple biological functions are known to be involved in disease resilience and this complexity means that the genetic architecture of disease resilience remains largely unknown. Here, we conducted genome-wide association studies (GWAS)...
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Abstract A genomic region on chromosome 4 that is tagged by single nucleotide polymorphism (SNP) WUR0000125 (WUR) was previously found to be associated with host response to porcine reproductive and respiratory syndrome (PRRS) virus infection. The objectives of this study were to 1) determine whether genotype at the WUR SNP is also associated with resilience to a natural polymicrobial disease challenge, 2) investigate the relationship of genotype at the WUR SNP with genotype at its putative caus...
1 CitationsSource
#1Yulu Chen (Iowa State University)H-Index: 3
#2Laura E. Tibbs Cortes (Iowa State University)H-Index: 2
Last. PigGen CanadaH-Index: 2
view all 11 authors...
Disease resilience is the ability to maintain performance under pathogen exposure but is difficult to select for because breeding populations are raised under high health. Selection for resilience requires a trait that is heritable, easy to measure on healthy animals, and genetically correlated with resilience. Natural antibodies (NAb) are important parts of the innate immune system and are found to be heritable and associated with disease susceptibility in dairy cattle and poultry. Our objectiv...
1 CitationsSource
The objective was to estimate genetic parameters of performance and resilience of growing pigs under disease. Data were from 3,139 Yorkshire x Landrace wean-to-finish pigs that were exposed to a natural polymicrobial disease challenge that was established by entering naturally infected animals into a nursery barn, targeting various viral and bacterial diseases. The challenge was maintained by entering batches of 60 to 75 healthy nursery pigs every 3 weeks in a continuous flow system. Traits anal...
6 CitationsSource
#1Xuechun Bai (U of A: University of Alberta)H-Index: 1
#2Austin M. Putz (Iowa State University)H-Index: 4
Last. PigGen CanadaH-Index: 2
view all 10 authors...
Disease resilience is a valuable trait to help manage infectious diseases in livestock. It is anticipated that improved disease resilience will sustainably increase production efficiency, as resilient animals maintain their performance in the face of infection. The objective of this study was to identify phenotypes related to disease resilience using complete blood count (CBC) data from a wean-to-finish natural disease challenge model, established to mimic the disease pressure caused by many com...
4 CitationsSource
#1Xuechun Bai (U of A: University of Alberta)H-Index: 1
#2Austin M. Putz (Iowa State University)H-Index: 4
Last. Graham Plastow (U of A: University of Alberta)H-Index: 54
view all 8 authors...
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