Renaud de Crevoisier
University of Rennes
CancerInternal medicineRadiologyUrologySurgeryMagnetic resonance imagingOncologyArtificial intelligenceImage registrationPattern recognitionProstateProstate cancerRectumPopulationNuclear medicineComputer visionComputer scienceRadiation therapyMedicineImage-guided radiation therapy
Publications 137
Abstract Background To improve the early detection of responders to salvage external beam radiotherapy (RT) after radical prostatectomy (RP). Methods Between 2002 and 2007, in a single institution, 136 consecutive patients received salvage RT to a dose of 66 Gy without androgen-deprivation therapy after RP for a rising prostate-specific antigen (PSA) level. PSA measurements were systematically performed before RT (PSA RT ), at the fifth week of RT (PSA5), and in the follow-up at least twice a ye...
7 CitationsSource
#1B. Rigaud (University of Rennes)H-Index: 10
#2Antoine Simon (University of Rennes)H-Index: 17
Last. Renaud de Crevoisier (University of Rennes)H-Index: 28
view all 9 authors...
In the context of head and neck cancer (HNC) adaptive radiation therapy (ART), the two purposes of the study were to compare the performance of multiple deformable image registration (DIR) methods and to quantify their impact for dose accumulation, in healthy structures. Fifteen HNC patients had a planning computed tomography (CT0) and weekly CTs during the 7 weeks of intensity-modulated radiation therapy (IMRT). Ten DIR approaches using different registration methods (demons or B-spline free fo...
44 CitationsSource
#2Camille BuscailH-Index: 10
Last. Marc Cuggia (French Institute of Health and Medical Research)H-Index: 4
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Background The performance of randomized controlled trials (RCTs) is often hindered by recruitment difficulties. This study aims to explore the pre-screening phase of four prostate cancer RCTs to identify the impact of a systematic pre-selection of eligible patients for RCT recruitment.
9 CitationsSource
#1Joël Castelli (French Institute of Health and Medical Research)H-Index: 17
#2Antoine Simon (French Institute of Health and Medical Research)H-Index: 17
Last. Renaud de Crevoisier (French Institute of Health and Medical Research)H-Index: 28
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Background Large anatomical variations occur during the course of intensity-modulated radiation therapy (IMRT) for locally advanced head and neck cancer (LAHNC). The risks are therefore a parotid glands (PG) overdose and a xerostomia increase. The purposes of the study were to estimate: - the PG overdose and the xerostomia risk increase during a “standard” IMRT (IMRTstd); - the benefits of an adaptive IMRT (ART) with weekly replanning to spare the PGs and limit the risk of xerostomia.
74 CitationsSource
Jan 1, 2015 in EMBC (International Conference of the IEEE Engineering in Medicine and Biology Society)
#1Frederic Commandeur (French Institute of Health and Medical Research)H-Index: 13
#1Frederic Commandeur (French Institute of Health and Medical Research)H-Index: 6
Last. Renaud de Crevoisier (French Institute of Health and Medical Research)H-Index: 28
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Multi-parametric magnetic resonance imaging (mMRI) is the standard exam for prostate cancer diagnosis, staging and risk assessment in current clinical routine. Correlating mMRI in-vivo observations with biological findings from radical prostatectomy specimen would improve the optimal therapy selection. Thus, we proposed a method for reconstructing and registering the prostate whole-mount histology (WMH) to the MRI, considering a thin slicing of the prostatectomy specimen. The method was evaluate...
6 CitationsSource
#1A. Fargeas (University of Rennes)H-Index: 5
#2Laurent Albera (University of Rennes)H-Index: 24
Last. Oscar Acosta (University of Rennes)H-Index: 21
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Abstract External beam radiotherapy is commonly prescribed for prostate cancer. Although new radiation techniques allow high doses to be delivered to the target, the surrounding healthy organs (rectum and bladder) may suffer from irradiation, which might produce undesirable side-effects. Hence, the understanding of the complex toxicity dose–volume effect relationships is crucial to adapt the treatment, thereby decreasing the risk of toxicity. In this paper, we introduce a novel method to classif...
9 CitationsSource
#1Juan David Ospina (National University of Colombia)H-Index: 8
#2J. ZhuH-Index: 6
Last. Renaud de CrevoisierH-Index: 28
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Purpose To propose a random forest normal tissue complication probability (RF-NTCP) model to predict late rectal toxicity following prostate cancer radiation therapy, and to compare its performance to that of classic NTCP models. Methods and Materials Clinical data and dose-volume histograms (DVH) were collected from 261 patients who received 3-dimensional conformal radiation therapy for prostate cancer with at least 5 years of follow-up. The series was split 1000 times into training and validat...
32 CitationsSource
#1Guillaume Cazoulat (French Institute of Health and Medical Research)H-Index: 12
#2Antoine Simon (French Institute of Health and Medical Research)H-Index: 17
Last. Pascal Haigron (French Institute of Health and Medical Research)H-Index: 21
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This paper addresses the issue of cumulative dose estimation from cone beam computed tomography (CBCT) images in prostate cancer radiotherapy. It focuses on the dose received by the surfaces of the main organs at risk, namely the bladder and rectum. We have proposed both a surface-constrained dose accumulation approach and its extensive evaluation. Our approach relied on the nonrigid registration (NRR) of daily acquired CBCT images on the planning CT image. This proposed NRR method was based on ...
22 CitationsSource
#1Fabio Martínez (National University of Colombia)H-Index: 6
#2Eduardo Romero (National University of Colombia)H-Index: 19
Last. Oscar Acosta (University of Rennes)H-Index: 21
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Accurate segmentation of the prostate and organs at risk in computed tomography (CT) images is a crucial step for radiotherapy planning. Manual segmentation, as performed nowadays, is a time consuming process and prone to errors due to the a high intra- and inter-expert variability. This paper introduces a new automatic method for prostate, rectum and bladder segmentation in planning CT using a geometrical shape model under a Bayesian framework. A set of prior organ shapes are first built by app...
34 CitationsSource
#1Caroline Lafond (University of Rennes)H-Index: 15
#2Frédéric GassaH-Index: 2
Last. M.-C. BistonH-Index: 7
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PURPOSE: To investigate the performances of two commercial treatment planning systems (TPS) for Volumetric Modulated Arc Therapy (VMAT) optimization regarding prostate cancer. The TPS were compared in terms of dose distributions, treatment delivery parameters and quality control results. MATERIALS AND METHODS: For ten patients, two VMAT plans were generated: one with Monaco TPS (Elekta) and one with Pinnacle TPS (Philips Medical Systems). The total prescribed dose was 78 Gy delivered in one 360°...
15 CitationsSource