Jianping Chen
University of Hong Kong
CancerInternal medicineOncologyRandomized controlled trialChemistryTraditional Chinese medicineApoptosisImmunologyAlternative medicineIn vivoIsoliquiritigeninMetastasisCancer researchBreast cancerClinical trialTraditional medicineCell growthMedicineBiologyCancer cellPharmacology
98Publications
27H-index
2,012Citations
Publications 96
Newest
#2Yong Tang (MUST: Macau University of Science and Technology)H-Index: 11
Last. An-Guo WuH-Index: 11
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Abstract null null Ethnopharmacological relevance null In the past five years, ethnopharmacy-based drugs have been increasingly used in clinical practice. It has been reported that hundreds of ethnopharmacy-based drugs can modulate autophagy to regulate physiological and pathological processes, and ethnomedicines also have certain therapeutic effects on illnesses, revealing the important roles of these medicines in regulating autophagy and treating diseases. null null null Aim of the study null ...
Source
#1Kumar GanesanH-Index: 17
Last. Jianping ChenH-Index: 27
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Breast cancer (BC) is the second most common cancer in women globally after lung cancer. Presently, the most important approach for BC treatment consists of surgery, followed by radiotherapy and chemotherapy. The latter therapeutic methods are often unsuccessful in the treatment of BC because of their various side effects and the damage incurred to healthy tissues and organs. Currently, numerous nanoparticles (NPs) have been identified and synthesized to selectively target BC cells without causi...
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#1Feng Zhang (HKU: University of Hong Kong)H-Index: 1
#2Qingqing Liu (HKU: University of Hong Kong)H-Index: 1
Last. Jianping Chen (HKU: University of Hong Kong)H-Index: 27
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Breast cancer (BCa) is the leading cause of women’s death worldwide; among them, triple-negative breast cancer (TNBC) is one of the most troublesome subtypes with easy recurrence and great aggressive properties. Spatholobus suberectus Dunn has been used in the clinic of Chinese society for hundreds of years. Shreds of evidence showed that Spatholobus suberectus Dunn has a favorable outcome in the management of cancer. However, the anti-TNBC efficacy of Spatholobus suberectus Dunn percolation ext...
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#3Zhang Lu (HKU: University of Hong Kong)H-Index: 4
Reactive oxygen species (ROS)/reactive nitrogen species (RNS)-mediated ferroptosis becomes a novel effective target for anti-cancer treatment. In the present study, we tested the hypothesis that 18-β-glycyrrhetinic acid (GA), an active compound from medicinal herbal Licorice, could induce the production of ROS/RNS, increase lipid peroxidation and trigger ferroptosis in MDA-MB-231 triple negative breast cancer cells. To confirm the GA's anti-cancer effects, we detected cell viability, apoptosis a...
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#1Hongni Zhu (HKU: University of Hong Kong)H-Index: 1
#2Jeishu You (HKU: University of Hong Kong)H-Index: 1
Last. Jianping Chen (HKU: University of Hong Kong)H-Index: 27
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Abstract null null Ethnopharmacological relevance null The root of Angelica sinensis is widely used in traditional Chinese Medicine for relieving gynecological discomforts among the women population. However, its hormone-like effects have raised great attention on whether it is appropriate to use in breast cancer (BC) patients. Hence, this study aimed to investigate the tumorigenic effect of aqueous root extract of Angelica sinensis (AS) on estrogen receptor (ER)-positive BC growth through ER-in...
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#5Yan Bo Zhang (HKU: University of Hong Kong)H-Index: 6
#1Fu Peng (HKU: University of Hong Kong)H-Index: 9
#2Hailin Tang (SYSU: Sun Yat-sen University)H-Index: 39
Last. Cheng Peng (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 33
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Triple-negative breast cancer (TNBC) is the subtype of breast cancer with more aggressive growth and metastasis and without efficient therapies. Hence, it is worthwhile to search for potential effective drug candidates. According to our previous study, isoliquiritigenin (ISL) exerted a potent anticancer effect on breast cancer proliferation. Its effect on TNBC growth, metastasis and mechanism deserves further investigation. In this study, PCR array screened a significant increase of miR-200c in ...
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#1Feng Wan (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 4
#2Fu Peng (HKU: University of Hong Kong)H-Index: 9
Last. Min Dai (Chengdu Medical College)H-Index: 3
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Objective To investigate the antibacterial activity of patchouli alcohol (PA) against 127 bacteria strains, including the common bacteria and drug-resistant bacteria strains both in the in vitro and in vivo tests.
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Last. Jianping ChenH-Index: 27
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Background: Depression is a mental illness that disturbs an individual’s health, which exacerbates the development of BC and reduces the quality of an individual’s life. Objective: To investigate the impacts of Traditional Chinese Medicine Music (TCMM) intervention on the depressed BC mouse model and explore the potential underlying mechanisms. Methodology: The intervention of TCMM and its impact on the body weight, tumor size, tumor weight, and behavioral tests were conducted in Chronic Mild St...
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