Edina Szabo
University of Calgary
Drug resistanceOrganismImmunoglobulin ECytotoxic T cellAntibodyHelminthsCD8Cell typeModel organismImmunologyIn vivoToxoplasmosisToxoplasma gondiiCytokineHeligmosomoides polygyrusMesenteric lymph nodesImmunityC57BL/6Multiple ModelsHelminthiasisContext (language use)GranulomaSpleenChange over timeChronic infectionProtozoan parasiteClinical settingsComputational biologyInterleukinIL-2 receptorBiologyImmune system
6Publications
1H-index
23Citations
Publications 6
Newest
#1Edina Szabo (U of C: University of Calgary)H-Index: 1
#2Bowhay C (U of C: University of Calgary)
Last. Constance A. M. FinneyH-Index: 15
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Co-infections are a common reality but understanding how the immune system responds in this context is complex and can be unpredictable. Despite this, it is key to develop models that will provide better translatability to real world situations. Heligmosomoides polygyrus (parasitic roundworm) and Toxoplasma gondii (protozoan parasite) are well studied organisms that stimulate a characteristic Th2 and Th1 response respectively. IFN{gamma}-producing T cells, NK and {gamma}{delta} T cells contribut...
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#1Anupama Ariyaratne (U of C: University of Calgary)H-Index: 1
#2S. Y. Kim (UCR: University of California, Riverside)
Last. Constance A. M. Finney (U of C: University of Calgary)H-Index: 15
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ABSTRACT Intestinal roundworms cause chronic debilitating disease in animals, including humans. A lack of effective vaccines and the emergence of widespread drug resistance only increase the need to better understand parasite clearance mechanisms within the host. Heligmosomoides polygyrus larvae induce a strong intestinal granuloma response within their murine host, which has been associated with resistance. Immune cells, mostly alternatively activated macrophages and eosinophils, accumulate aro...
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#1Joel Bowron (U of C: University of Calgary)H-Index: 1
#2Anupama Ariyaratne (U of C: University of Calgary)H-Index: 1
Last. Constance A. M. Finney (U of C: University of Calgary)H-Index: 15
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Disrupting/harnessing immune suppression is leading to new therapeutic avenues in a number of immune-related diseases. Understanding the suppressive functions of regulatory T cells (Tregs) in different environments is therefore key. Parasitic worms are strong inducers of Tregs and previous research has suggested that parasite-induced Tregs are stronger suppressors than naive Tregs. In strains susceptible to the intestinal worm Heligmosomoides polygyrus, like C57BL/6 mice, it has been hypothesize...
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#1Anupama Ariyaratne (U of C: University of Calgary)H-Index: 1
#2Edina Szabo (U of C: University of Calgary)H-Index: 1
Last. Constance A. M. Finney (U of C: University of Calgary)H-Index: 15
view all 4 authors...
Abstract IL-21 is a much studied cytokine that has been implicated in the regulation of TH1, TH2, TH17 and regulatory immune responses; its signalling is a promising therapeutic target for autoimmune, inflammatory and infectious diseases. Despite its biological importance, measuring IL-21 reliably has proved difficult. ELISAs are commonly used to measure cytokines in various biological samples. However, results obtained are only as good as the quality of the sample. Here, we show that when using...
1 CitationsSource
#1Edina Szabo (U of C: University of Calgary)H-Index: 1
#2Constance A. M. Finney (U of C: University of Calgary)H-Index: 15
Toxoplasma gondii is an intensely studied protozoan parasite. It is also used as a model organism to research additional clinically relevant human and veterinary parasites due to ease of in vitro culture and genetic manipulation. Recently, it has been developed as a model of inflammatory bowel disease, due to their similar pathologies. However, researchers vary widely in how they use T. gondii , which makes study comparisons and interpretation difficult. The aim of this review is to provide rese...
21 CitationsSource