Alejandra Romero-Montero
National Autonomous University of Mexico
CytotoxicityIrradiationHydrogen bondBiophysicsConductivityNuclear chemistryComputational chemistryCopolymerProinflammatory cytokineIntermolecular forceEnzymeAqueous solutionChemistryElectron paramagnetic resonancePolymer chemistryMaterials scienceSide chainSelf-assemblyOxidative stressInflammationIC50AntioxidantGallic acidBiomaterialAmideCytokineCitric acidStaphylococcus aureusPolycaprolactoneEnterococcus faecalisFibroblastCell cycleSpectroscopyMoleculeChemical engineeringPolymerizationReactive oxygen speciesAntimicrobialTissue engineeringPolymerBacteriaViability assayBiochemistryCell growthProtein secondary structureContact anglePolyphenolCrystallographyCell cultureAdhesionCell adhesionNanocompositeSupramolecular chemistryCell biologyDiamagnetism
8Publications
3H-index
22Citations
Publications 8
Newest
The self-assembly behavior of chemoenzymatic high molecular weight (ca. 30 000 Da) poly-L-phenylalanine (ePLP) and the nano-morphologies thereof are investigated. Interestingly, this supramolecular ePLP changes from a non-ordered secondary structure when solubilized in water to an α-helix with the addition of only 1 vol% HFIP co-solvent, and at a relatively low concentration (0.5 mg mL−1). The results also indicate a temperature-dependent structural stabilization, wherein the self-assembly proce...
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Cytokines like IL-6, TNF-α, and IL-1β are important mediators of inflammation in many inflammatory diseases, as well as in cellular processes like cell proliferation and cell adhesion. Finding new molecules that decrease cell proliferation, adhesion (inflammatory infiltrate), and pro-inflammatory cytokine release could help in the treatment of many inflammatory diseases. The naturally derived poly(gallic acid) (PGAL), produced enzymatically from gallic acid in aqueous medium, is a non-toxic, the...
2 CitationsSource
#1Alejandra Romero-Montero (UNAM: National Autonomous University of Mexico)H-Index: 3
#2Luis J. del ValleH-Index: 27
Last. Miquel Gimeno (UNAM: National Autonomous University of Mexico)H-Index: 18
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Abstract Enzymatic mediated poly (gallic acid) (PGAL), a stable multiradical polyanion with helicoidal secondary structure and high antioxidant capacity, was successfully grafted to poly(e-caprolactone) (PCL) using UV-photo induction. PCL films were prepared with several levels of roughness and subsequently grafted with PGAL (PCL-g-PGAL). The results on the full characterization of the produced materials by mechanical tests, surface morphology, and topography, thermal and crystallographic analys...
1 CitationsSource
#1Alejandra Romero-Montero (UNAM: National Autonomous University of Mexico)H-Index: 3
#2Pablo Labra-Vázquez (UNAM: National Autonomous University of Mexico)H-Index: 5
Last. Miquel Gimeno (UNAM: National Autonomous University of Mexico)H-Index: 18
view all 7 authors...
A nanocomposite based on an antibiotic-loaded hydrogel into a nano-electrospun fibre with antimicrobial and antioxidant capacities is investigated. The material is composed of nanofibres of enzymatic PCL grafted with poly(gallic acid) (PGAL), a recently developed enzyme-mediated hydrophilic polymer that features a multiradical and polyanionic nature in a helicoidal secondary structure. An extensive experimental–theoretical study on the molecular structure and morphological characterizations for ...
2 CitationsSource
#1Alejandra Romero-Montero (UNAM: National Autonomous University of Mexico)H-Index: 3
#2Miquel Gimeno (UNAM: National Autonomous University of Mexico)H-Index: 18
Last. Pablo Labra-Vázquez (UNAM: National Autonomous University of Mexico)H-Index: 5
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Abstract In this work we re-examined the molecular structure of enzymatic poly(gallic acid) (PGAL), for which we identified a multiradical and polyanionic nature, in contrast to a previous assignment where it was mistakenly assumed as a neutral and diamagnetic molecule. Here, we present a profound investigation of its ground-state structure by the use of both experimental and theoretical methods, featuring ESR measurements and quantum chemical computations. It was found that its multiradical nat...
5 CitationsSource
#2Alejandra Romero-Montero (UNAM: National Autonomous University of Mexico)H-Index: 3
Last. Miquel Gimeno (UNAM: National Autonomous University of Mexico)H-Index: 18
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Abstract The poly(gallic acid), produced by laccase-mediated oxidation of gallic acid in aqueous media (pH 5.5) to attain a novel material with well-defined molecular structure and high water solubility (500 mg/mL at 25 °C), has been investigated to understand its potential biological activities. In this regard, a biomedical approach based on cytoprotective effect on human fibroblast cells exposed to UV-irradiation in the presence of the polymer has been demonstrated. The results also shows that...
5 CitationsSource
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#1Alejandra Romero-Montero (UNAM: National Autonomous University of Mexico)H-Index: 3
#2Alberto Tecante (UNAM: National Autonomous University of Mexico)H-Index: 22
Last. Miquel Gimeno (UNAM: National Autonomous University of Mexico)H-Index: 18
view all 7 authors...
Poly(gallic acid), a novel polymer obtained by enzymatic polymerization of gallic acid, was successfully cross-linked to carboxymethylcellulose using citric acid as a cross-linker. Non-woven sheets were prepared with the resulting copolymer and their in vitro biocompatibility was assessed. The results on the characterizations of the produced films by mechanical tests, water vapour permeability, contact angle, and antioxidant activity by electronic paramagnetic resonance were adequate for skin ti...
7 CitationsSource