Linlin Su
Fourth Military Medical University
Downregulation and upregulationCell migrationPathologyMolecular biologyGene knockdownChemistryExtracellular matrixImmunologyMyofibroblastInflammationHypertrophic scarWound healingFibrosisCancer researchSignal transductionMedicineProtein kinase BPI3K/AKT/mTOR pathwayBiologyCell biology
52Publications
18H-index
870Citations
Publications 52
Newest
#1Zichao Li (Fourth Military Medical University)H-Index: 1
#2Xiaozhi Bai (Fourth Military Medical University)H-Index: 21
Last. Dahai Hu (Fourth Military Medical University)H-Index: 26
view all 16 authors...
Although it is well-known that human skin aging is accompanied by an alteration in the skin microbiota, we know little about how the composition of these changes during the course of aging and the effects of age-related skin microbes on aging. Using 16S ribosomal DNA and internal transcribed spacer ribosomal DNA sequencing to profile the microbiomes of 160 skin samples from two anatomical sites, the cheek and the abdomen, on 80 individuals of varying ages, we developed age-related microbiota pro...
2 CitationsSource
#1Linlin Su (Fourth Military Medical University)H-Index: 18
#2Zhaohua WangH-Index: 1
Last. Yongjun Guan (HUM: Hubei University of Medicine)H-Index: 1
view all 7 authors...
The blood-testis barrier (BTB) separates the seminiferous epithelium into the apical and basal compartments. The BTB has to operate timely and accurately to ensure the correct migration of germ cells, meanwhile maintaining the immunological barrier. Testin was first characterized from primary Sertoli cells, it is a secretory protein and a sensitive biomarker to monitor junctions between Sertoli and germ cells. Till now, the functions of testin on BTB dynamics and the involving mechanisms are unk...
4 CitationsSource
#1Linlin Su (Fourth Military Medical University)H-Index: 18
#2Jianping Zheng (Huda: Hubei University)H-Index: 2
Last. Dahai Hu (Fourth Military Medical University)H-Index: 26
view all 5 authors...
Abstract Normal wound repair is a dynamic and complex process involving multiple coordinated interactions between growth factors, cytokines, chemokines, and various cells. Any failure during the repair process may cause chronic wounds or scar formation, which increase the financial burden of patients due to repetitive treatments and considerable medical expenditures, and affect their quality of life. Nowadays, extensive efforts have been made to develop novel therapeutics for wound repair. Genet...
11 CitationsSource
#1Bin Zhao (Fourth Military Medical University)H-Index: 10
#2Jiaqi Liu (Fourth Military Medical University)H-Index: 18
Last. Dahai Hu (Fourth Military Medical University)H-Index: 26
view all 8 authors...
Source
#1Fangfang Yang (Fourth Military Medical University)H-Index: 2
#2Erfei Chen (Northwest University (United States))H-Index: 1
Last. Dahai Hu (Fourth Military Medical University)H-Index: 26
view all 11 authors...
: Hypertrophic scars (HS) are characterized by the excessive production and deposition of extracellular matrix (ECM) proteins. Pentoxifylline (PTX), a xanthine derived antioxidant, inhibits the proliferation, inflammation and ECM accumulation of HS. In this study, we aimed to explore the effect of PTX on HS and further clarify the mechanism of PTX-induced anti-proliferation. We found that PTX could significantly attenuate proliferation of HS fibroblasts and fibrosis in an animal HS model. PTX in...
6 CitationsSource
#1Xiao-Qiang Li (Fourth Military Medical University)H-Index: 17
#2Gaofeng Wu (Fourth Military Medical University)H-Index: 4
Last. Dahai Hu (Fourth Military Medical University)H-Index: 26
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Abstract Objective Chronic wounds are a devastating complication of diabetes and can lead to amputations or even death. Current medical therapies are insufficient to accelerate its repair. The objective of this study was to explore the role of Sirtuin1 (SIRT1) in diabetic wounds. Methods and materials Perilesional skin tissue samples from diabetic ulcers and normoglycemic trauma wounds were used to detect SIRT1 expression and oxidative stress levels. In a diabetic mouse model, SIRT1 was pharmaco...
10 CitationsSource
#1Wei Zhang (Fourth Military Medical University)H-Index: 31
#2Xiaozhi Bai (Fourth Military Medical University)H-Index: 21
Last. Dahai Hu (Fourth Military Medical University)H-Index: 26
view all 16 authors...
Abstract Introduction Adipose tissue-derived stem cells (ADSCs) have been shown to enhance wound healing via their paracrine function. Exosomes, as one of the most important paracrine factors, play an essential role in this process. However, the concrete mechanisms that underlie this effect are poorly understood. In this study, we aim to explore the potential roles and molecular mechanisms of exosomes derived from ADSCs in cutaneous wound healing. Methods Normal human skin fibroblasts and ADSCs ...
74 CitationsSource
#1Yunchuan Wang (Fourth Military Medical University)H-Index: 1
#2Jianping Zheng (Huda: Hubei University)H-Index: 2
Last. Xiaobing Fu (Chinese PLA General Hospital)H-Index: 29
view all 7 authors...
Junctional adhesion molecule-A (JAM-A) belongs to the immunoglobulin superfamily, it predominantly exists at the tight junctions of epithelial and endothelial cells. JAM-A is known to regulate leukocyte trans-endothelial migration, however, how it affects the proliferation and migration of keratinocytes, the two essential steps during wound healing, has less been explored. In this study, we showed that JAM-A was significantly expressed in normal skin epidermis. RNAi-mediated JAM-A knockdown rema...
5 CitationsSource
#1Bin Zhao (Fourth Military Medical University)H-Index: 1
#2Xiaodong LiH-Index: 3
Last. Dahai Hu (Fourth Military Medical University)H-Index: 26
view all 9 authors...
Previous work in our laboratory demonstrated that exosomes derived from human amniotic epithelial cells (hAECs) accelerated wound healing by promoting the proliferation and migration of fibroblasts. It is reported that exosomes, which are carriers of the microRNAs (miRNAs) and proteins, play an important role in the regulation of cell-to-cell communication. However, it is still unclear precisely which molecule or which group of molecules carried within hAEC-derived exosomes (hAEC-Exos) mediated ...
16 CitationsSource
#1Yang Liu (Fourth Military Medical University)H-Index: 17
#2Hao Guan (Fourth Military Medical University)H-Index: 16
Last. Dahai Hu (Fourth Military Medical University)H-Index: 26
view all 9 authors...
MiR-199a is a novel gene regulator with an important role in inflammation and lung injury. However, its role in the pathogenesis of sepsis-induced acute respiratory distress syndrome (ARDS) is currently unknown. Our study explored the role of miR-199a in sepsis-induced ARDS and its mechanism of action. First, we found that LPS could up-regulate miR-199a in alveolar macrophages. Down-regulation of miR-199a inhibited the up-regulation of inflammatory cytokines in alveolar macrophages and induced t...
30 CitationsSource