Veerle Van Marck
University of Münster
PharmacokineticsCollagen receptorBiomarker discoveryNephrotoxicityUrologyCalcineurinAngiomotinUnfolded protein responsePathologyMagnetic resonance imagingDNA damageAbsorption (skin)Cellular differentiationFocal adhesionLive cell imagingIntegrin, beta 6Renal functionTranscriptomeProinflammatory cytokineReceptorIntegrin alpha MHippo signaling pathwayMedullaHepatic stellate cellRadiochemistryKinaseTranscytosisChemistryOrganic cation transport proteinsLiver cytologyIntegrinLanthanideIn vitroImmunologyIn vivoWild typeBiopsyNutrient sensingHepatocyteLeukocyte adhesion deficiencyKlebsiella pneumoniaePodocyteGlomerulosclerosisLungInfiltration (medical)PIKFYVECisplatinDisintegrinTumor initiationPulse wave velocityOtotoxicityVacuolizationLanthanum carbonatePhosphate binderSoluble fms-like tyrosine kinase-1NeurotoxicityLOXL2L-selectinKidneyReperfusion injuryKidney transplantationFibrosisNephrinPathogenesisNephronExtracellularHippo signalingTacrolimusNephrocyte filtrationGlomerular Filtration BarrierNephrocyte diaphragmRegulatory PathwayToxicityRenal fibrosisActin cytoskeletonChemical bindingSlit diaphragmKinase activityIn vitro toxicologyBlood volumeCD49cCancer researchCD18Scaffold proteinIschemiaCarcinogenesisLanthanumMetalloproteinaseGadoliniumPurinergic receptorCell growthSignal transductionMedicineDeposition (chemistry)Biomarker (medicine)Area under the curveIntracellularCell adhesionBiologyImmune systemCell biologyPharmacology
Publications 15
Fabry disease (FD) is caused by mutations in the α-galactosidase A (GLA) gene encoding the lysosomal AGAL enzyme. Loss of enzymatic AGAL activity and cellular accumulation of sphingolipids (mainly globotriaosylcermide) may lead to podocyturia and renal loss of function with increased cardiovascular morbidity and mortality in affected patients. To identify dysregulated cellular pathways in FD, we established a stable AGAL-deficient podocyte cell line to perform a comprehensive proteome analysis. ...
#1Konrad BuscherH-Index: 16
#2Barbara Heitplatz (WWU: University of Münster)H-Index: 8
Last. Stefan ReuterH-Index: 29
view all 13 authors...
BACKGROUND In transplant medicine, clinical decision-making largely relies on histology of biopsies. However, histology suffers from low specificity, sensitivity, and reproducibility, leading to suboptimal stratification of patients. We developed a histology-independent immune framework of kidney graft homeostasis and rejection. METHODS Tailored RNA deconvolution for leukocyte enumeration and co-regulated gene network analysis was applied to published bulk human kidney transplant RNA transcripto...
Background Crumbs2 is expressed at embryonic stages as well as in the retina, brain, and glomerular podocytes. Recent studies identified CRB2 mutations as a novel cause of steroid-resistant nephrotic syndrome (SRNS). Methods To study the function of Crb2 at the renal filtration barrier, mice lacking Crb2 exclusively in podocytes were generated. Gene expression and histologic studies as well as transmission and scanning electron microscopy were used to analyze these Crb2 podKO knockout mice and t...
#1Patrick Bücker (WWU: University of Münster)H-Index: 3
#2Henning Richter (UZH: University of Zurich)H-Index: 10
Last. Uwe Karst (WWU: University of Münster)H-Index: 61
view all 10 authors...
Abstract Background Recently, gadolinium from linear GBCAs has been reported to deposit in various regions of the body. Besides gadolinium, other lanthanides are used in medical care. In the current study, we investigated deposition of lanthanum in two patients who received lanthanum carbonate as a phosphate binder due to chronic kidney injury and compared it to additionally found Gd deposition. Material and Methods: Tissue specimens of two patients with long-term application of lanthanum carbon...
#1Isabel Schulien (University of Freiburg)H-Index: 5
#2Birgit Hockenjos (University of Freiburg)H-Index: 8
Last. Peter Hasselblatt (University of Freiburg)H-Index: 19
view all 7 authors...
Release of adenosine triphosphate (ATP) to the extracellular compartment and subsequent activation of purinergic receptors is a conserved mechanism mediating inflammatory responses and cell fate decisions in various organs including the liver. Previous findings suggest that extracellular ATP may promote liver tumorigenesis; however, the underlying mechanisms are poorly understood. Therefore, our aim was to dissect the functions of extracellular ATP and P2Y2 receptors (P2Y2R) during hepatocarcino...
#1Anika CappenbergH-Index: 1
#2Andreas MargrafH-Index: 11
Last. Alexander ZarbockH-Index: 72
view all 9 authors...
Pneumonia induced by gram-negative bacteria is a common and serious disease associated with high morbidity and mortality. Elimination of bacterial pathogens relies on the recruitment and functions of neutrophils. The adhesion molecule L-selectin has recently been implicated in integrin activation in neutrophils (inside-out-signaling). However, the molecular mechanism how L-selectin participates in host defense against Klebsiella pneumoniae-induced pulmonary inflammation is unknown. We demonstrat...
Fast tacrolimus metabolism is linked to inferior outcomes such as rejection and lower renal function after kidney transplantation. Renal calcineurin-inhibitor toxicity is a common adverse effect of tacrolimus therapy. The present contribution hypothesized that tacrolimus-induced nephrotoxicity is related to a low concentration/dose (C/D) ratio. We analyzed renal tubular epithelial cell cultures and 55 consecutive kidney transplant biopsy samples with tacrolimus-induced toxicity, the C/D ratio, C...
#10Alessia Chiorazzi (University of Milano-Bicocca)H-Index: 16
Cisplatin (CDDP) is one of the most important chemotherapeutic drugs in modern oncology. However, its use is limited by severe toxicities, which impair life quality after cancer. Here, we investigated the role of organic cation transporters (OCT) in mediating toxicities associated with chronic (twice the week for 4 weeks) low-dose (4 mg/kg body weight) CDDP treatment (resembling therapeutic protocols in patients) of wild-type (WT) mice and mice with OCT genetic deletion (OCT1/2−/−). Functional a...
Background Patients with certain mutations in the gene encoding the slit diaphragm protein Nephrin fail to develop functional slit diaphragms and display severe proteinuria. Many adult-onset glomerulopathies also feature alterations in Nephrin expression and function. Nephrin signals from the podocyte slit diaphragm to the Actin cytoskeleton by recruiting proteins that can interact with C3G, a guanine nucleotide exchange factor of the small GTPase Rap1. Because Rap activity affects formation of ...
#1Theresa M. WewersH-Index: 1
#2Anna B. MayerH-Index: 3
Last. Giovana Seno Di MarcoH-Index: 19
view all 12 authors...
Renal ischemia reperfusion injury (IRI) adversely affects clinical outcomes following kidney transplantation. Understanding the cellular mechanisms and the changes in gene/protein expression following IRI may help to improve these outcomes. Serum soluble fms-like tyrosine kinase 1 (sFlt-1), a circulating antiangiogenic protein, is increased in the first week following kidney transplantation. We evaluated the casual relationship of elevated sFlt-1 levels with renal microvascular dysfunction follo...
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