Rene Schmidt
University of Münster
Framingham Risk ScoreInternal medicineRadiologyOncologyRetrospective cohort studyPediatricsClinical endpointHazard ratioBiopsyChemotherapyGliomaNeurofibromatosisKidney transplantationMedulloblastomaPopulationLow-Grade GliomaIn patientMathematicsProportional hazards modelRadiation therapyClinical trialBioinformaticsMedicineCohortBiology
60Publications
14H-index
801Citations
Publications 66
Newest
OBJECTIVES The aim of this study was to compare the second trimester thymus-thorax-ratio (TTR) between fetuses born preterm (study group) and those born after 37 weeks of gestation were completed (control group). METHODS This study was conducted as a retrospective evaluation of the ultrasound images of 492 fetuses in the three vessel view. The TTR was defined as the quotient of a.p. thymus diameter and a.p. thoracic diameter. RESULTS Fetuses that were preterm showed larger TTR (p<0.001) the seco...
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#1J Feld (WWU: University of Münster)H-Index: 1
#2Andreas Faldum (WWU: University of Münster)H-Index: 37
Last. Rene Schmidt (WWU: University of Münster)H-Index: 14
view all 3 authors...
Whereas the theory of confirmatory adaptive designs is well understood for uncensored data, implementation of adaptive designs in the context of survival trials remains challenging. Commonly used adaptive survival tests are based on the independent increments structure of the log-rank statistic. This implies some relevant limitations: On the one hand, essentially only the interim log-rank statistic may be used for design modifications (such as data-dependent sample size recalculation). Furthermo...
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#1J FeldH-Index: 1
Last. Rene SchmidtH-Index: 14
view all 4 authors...
The one-sample log-rank test is the method of choice for single-arm Phase II trials with time-to-event endpoint. It allows to compare the survival of the patients to a reference survival curve that typically represents the expected survival under standard of care. The classical one-sample log-rank test, however, assumes that the reference survival curve is deterministic. This ignores that the reference curve is commonly estimated from historic data and thus prone to statistical error. Ignoring s...
#2Andreas FaldumH-Index: 37
Last. Rene SchmidtH-Index: 14
view all 3 authors...
Time-to-event endpoints show an increasing popularity in phase II cancer trials. The standard statistical tool for such endpoints in one-armed trials is the one-sample log-rank test. It is widely known, that the asymptotic providing the correctness of this test does not come into effect to full extent for small sample sizes. There have already been some attempts to solve this problem. While some do not allow easy power and sample size calculations, others lack a clear theoretical motivation and ...
#1Moritz Fabian Danzer (WWU: University of Münster)H-Index: 2
#2Tobias Terzer (DKFZ: German Cancer Research Center)H-Index: 4
Last. Rene Schmidt (WWU: University of Münster)H-Index: 14
view all 5 authors...
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#1Astrid Gnekow (Augsburg College)H-Index: 29
#2Daniela Kandels (Augsburg College)H-Index: 7
Last. Claudia Spix (University of Mainz)H-Index: 29
view all 12 authors...
BACKGROUND Successive multicenter studies for pediatric low-grade glioma (LGG) in Germany were accompanied by a doubling of annual recruitment over 2 decades. We investigated whether this increase conveyed a change of epidemiologic characteristics or survival. METHODS AND RESULTS Participating centers reported 4634 patients with the radiologic/histologic diagnosis of LGG (1996-2018), rising from 109 to 278/year. Relating these numbers to all pediatric CNS tumors registered at the German Childhoo...
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#1Thomas Perwein (Medical University of Graz)H-Index: 2
#2Martin Benesch (Medical University of Graz)H-Index: 32
Last. Astrid Gnekow (Augsburg College)H-Index: 29
view all 14 authors...
BACKGROUND Knowledge on management of pediatric spinal cord low-grade glioma (LGG) is scarce. METHODS We analyzed clinical datasets of 128 pediatric patients with spinal LGG followed within the prospective multicenter trials HIT-LGG 1996 (n=36), SIOP-LGG 2004 (n=56) and the subsequent LGG-Interim registry (n=36). RESULTS Spinal LGG, predominantly pilocytic astrocytomas (76%), harbored KIAA1549-BRAF fusion in 14/35 patients (40%) and FGFR1-TACC1 fusion in 3/26 patients (12%), as well as BRAFV600E...
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#1Holger Ottensmeier (Boston Children's Hospital)H-Index: 3
#2Paul G. Schlegel (Boston Children's Hospital)H-Index: 24
Last. Stefan Rutkowski (UHH: University of Hamburg)H-Index: 63
view all 17 authors...
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#1Juergen FoellH-Index: 3
Last. D. WolffH-Index: 13
view all 15 authors...
#1Fabian Falkenstein (Augsburg College)H-Index: 6
#2Marco Gessi (University of Bonn)H-Index: 33
Last. Torsten Pietsch (University of Bonn)H-Index: 108
view all 16 authors...
Reports on pediatric low-grade diffuse glioma WHO-grade II (DG2) suggest an impaired survival rate, but lack conclusive results for genetically defined DG2-entities. We analyzed the natural history, treatment and prognosis of DG2 and investigated which genetically defined sub-entities proved unfavorable for survival. Within the prospectively registered, population-based German/Swiss SIOP-LGG 2004 cohort 100 patients (age 0.8-17.8 years, 4% neurofibromatosis [NF1]) were diagnosed with a DG2. Foll...
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