Ana P.D. Mendes
Salk Institute for Biological Studies
PsychopharmacologyInduced pluripotent stem cellInternal medicinePhenotypeEndocrinologyNeural stem cellHippocampal formationPsychologyTranscriptomeNeuroscienceElectrophysiologyChemistryProgenitor cellAutismBipolar disorderDentate gyrusInflammationBonoboStem cellNeurogenesisMedicinePremovement neuronal activityBiologyNeuroinflammationCell biology
14Publications
6H-index
399Citations
Publications 14
Newest
#1Krishna C. Vadodaria (Salk Institute for Biological Studies)H-Index: 19
#2Ana P.D. Mendes (Salk Institute for Biological Studies)H-Index: 6
Last. Fred H. Gage (Salk Institute for Biological Studies)H-Index: 237
view all 14 authors...
Summary Bipolar disorder (BD) is characterized by cyclical mood shifts. Studies indicate that BD patients have a peripheral pro-inflammatory state and alterations in glial populations in the brain. We utilized an in vitro model to study inflammation-related phenotypes of astrocytes derived from induced pluripotent stem cells (iPSCs) generated from BD patients and healthy controls. BD astrocytes showed changes in transcriptome and induced a reduction in neuronal activity when co-cultured with neu...
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#1Renata Santos (Salk Institute for Biological Studies)H-Index: 24
#2Sara B. Linker (Salk Institute for Biological Studies)H-Index: 10
Last. Fred H. Gage (Salk Institute for Biological Studies)H-Index: 237
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Bipolar disorder (BD) is a psychiatric condition characterized by depressive and manic episodes that affect 2% of the world population. The first-line long-term treatment for mood stabilization is lithium (Li). Induced pluripotent stem cell modeling of BD using hippocampal dentate gyrus-like neurons derived from Li-responsive (LR) and Li-non-responsive (NR) patients previously showed neuronal hyperexcitability. Li treatment reversed hyperexcitability only on the LR neurons. In this study we sear...
1 CitationsSource
#1Thalita Figueiredo (USP: University of São Paulo)H-Index: 6
#2Ana P.D. Mendes (Salk Institute for Biological Studies)H-Index: 6
Last. Mayana Zatz (USP: University of São Paulo)H-Index: 71
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A homozygous mutation in the inositol monophosphatase 1 (IMPA1) gene was recently identified in nine individuals with severe intellectual disability (ID) and disruptive behavior. These individuals belong to the same family from Northeastern Brazil, which has 28 consanguineous marriages and 59 genotyped family members. IMPA1 is responsible for the generation of free inositol from de novo biosynthesis and recycling from inositol polyphosphates and participates in the phosphatidylinositol signaling...
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#1Shani Stern (University of Haifa)H-Index: 10
#2Anindita Sarkar (Salk Institute for Biological Studies)H-Index: 10
Last. Fred H. Gage (Salk Institute for Biological Studies)H-Index: 237
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Abstract Background We recently reported a hyperexcitability phenotype displayed in dentate gyrus (DG) granule neurons derived from bipolar disorder (BD) patients ( 1 , 2 ) and also a hyperexcitability that appeared only in CA3 pyramidal hippocampal neurons that were derived from BD patients who responded to lithium treatment (LR) but not from BD patients who were lithium non-responders (NR) ( 3 ). Methods Here we used our measurements of currents in neurons derived from 4 control individuals, 3...
4 CitationsSource
#1Shani Stern (University of Haifa)H-Index: 10
#2Anindita Sarkar (Salk Institute for Biological Studies)H-Index: 10
Last. Fred H. Gage (Salk Institute for Biological Studies)H-Index: 237
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Abstract Background Approximately one in every 50-100 people is affected with bipolar disorder (BD), making this disease a major economic burden. The introduction of the induced pluripotent stem cells (iPSCs) methodology enabled better modeling of this disorder. Methods Having previously studied the phenotype of dentate gyrus (DG) granule neurons, we turned our attention to studying the phenotype of CA3 hippocampal pyramidal neurons of 6 BD patients compared to 4 control individuals. We used pat...
7 CitationsSource
#1Sara B. Linker (Salk Institute for Biological Studies)H-Index: 10
#2Ana P.D. Mendes (Salk Institute for Biological Studies)H-Index: 6
Last. Maria C. Marchetto (UCSD: University of California, San Diego)H-Index: 47
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BACKGROUND Research evidence accumulated in the past years in both rodent and human models for autism spectrum disorders (ASD) have established insulin-like growth factor 1 (IGF-1) as one of the most promising ASD therapeutic interventions to date. ASD is phenotypically and etiologically heterogeneous, making it challenging to uncover the underlying genetic and cellular pathophysiology of the condition; and to efficiently design drugs with widespread clinical benefits. While IGF-1 effects have b...
1 CitationsSource
#1Debha Amatya (UCSD: University of California, San Diego)H-Index: 5
#2Sara B. Linker (Salk Institute for Biological Studies)H-Index: 10
Last. Yeni Kim (Salk Institute for Biological Studies)H-Index: 3
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Summary Neuronal activity can be modeled as a nonlinear dynamical system to yield measures of neuronal state and dysfunction. The electrical recordings of stem cell-derived neurons from individuals with autism spectrum disorder (ASD) and controls were analyzed using minimum embedding dimension (MED) analysis to characterize their dynamical complexity. MED analysis revealed a significant reduction in dynamical complexity in ASD neurons during differentiation, which was correlated to bursting and ...
3 CitationsSource
#1Maria C. Marchetto (Salk Institute for Biological Studies)H-Index: 47
#2Branka Hrvoj-Mihic (UCSD: University of California, San Diego)H-Index: 8
Last. Fred H. Gage (Salk Institute for Biological Studies)H-Index: 237
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: Comparative analyses of neuronal phenotypes in closely related species can shed light on neuronal changes occurring during evolution. The study of post-mortem brains of nonhuman primates (NHPs) has been limited and often does not recapitulate important species-specific developmental hallmarks. We utilize induced pluripotent stem cell (iPSC) technology to investigate the development of cortical pyramidal neurons following migration and maturation of cells grafted in the developing mouse cortex....
41 CitationsSource
#1Beatriz C.G. Freitas (USP: University of São Paulo)H-Index: 15
#1Beatriz C Freitas (USP: University of São Paulo)H-Index: 1
Last. Maria C. Marchetto (Salk Institute for Biological Studies)H-Index: 47
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Recent reports show an increase in the incidence of Autism Spectrum Disorders (ASD) to 1 in every 59 children up to 8 years old in 11 states in North America. Induced pluripotent stem cell (iPSC) technology offers a groundbreaking platform for the study of polygenic neurodevelopmental disorders in live cells. Robust inflammation states and immune system dysfunctions are associated with ASD and several cell types participate on triggering and sustaining these processes. In this review, we will ex...
7 CitationsSource
#1Maria C. Marchetto (Salk Institute for Biological Studies)H-Index: 47
#2Branka Hrvoj-Mihic (UCSD: University of California, San Diego)H-Index: 8
Last. Fred H. Gage (Salk Institute for Biological Studies)H-Index: 237
view all 25 authors...
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