Jaejung Song
Pohang University of Science and Technology
Colloidal goldPlasmonOpticsQuenching (fluorescence)Quantum dotBiophysicsNanoparticleNanotechnologyPhotothermal therapyChemistryNanostructureThin filmScatteringMaterials scienceBioconjugationCondensed matter physicsOptical coherence tomographyDoxorubicinCancer therapySynergistic combinationOrthorhombic crystal systemNear-infrared spectroscopyOptoelectronicsLaserDNAAbsorption (electromagnetic radiation)Resolution (electron density)Optical microscopeJahn–Teller effectFluorescenceNanocomposite
21Publications
12H-index
572Citations
Publications 21
Newest
#1Gyudong Lee (POSTECH: Pohang University of Science and Technology)H-Index: 1
#2Jaejung Song (POSTECH: Pohang University of Science and Technology)H-Index: 12
Last. Sungjee Kim (POSTECH: Pohang University of Science and Technology)H-Index: 48
view all 8 authors...
This paper demonstrates fabrication of silica-shell-coated magnetic nanoparticle clusters (SMNCs) and subsequent surface engineering of SMNCs to produce surface-modified SMNCs that have zwitterionic and primary amine ligands (SMNC-ZW/Am). SMNC-ZW/Am was passivated by zwitterionic ligands for improved colloidal stability and reduced nonspecific adsorption and by primary amine ligands for facilitated conjugation with biomolecules. Hydrodynamic (HD) size and zeta potential of SMNC-ZW/Am could be fl...
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#1Sanghwa Jeong (POSTECH: Pohang University of Science and Technology)H-Index: 11
#2Yebin Jung (POSTECH: Pohang University of Science and Technology)H-Index: 7
Last. Sungjee Kim (POSTECH: Pohang University of Science and Technology)H-Index: 48
view all 11 authors...
: PbS/CdS core/shell quantum dots (QDs) that emit at the second near-infrared (NIR-II, 1000-1700 nm) window are synthesized. The PbS seed size and CdS shell thicknesses are carefully controlled to produce bright and narrow fluorescence that are suitable for multiplexing. A polymer encapsulation yields polymer-encapsulated NIR-II QDs (PQDs), which provides the QDs with long-term fluorescence stability over a week in biological media. Exploiting the simple bioconjugation capability of PQDs, folic ...
7 CitationsSource
#1Jaejung Song (POSTECH: Pohang University of Science and Technology)H-Index: 12
#2Minhyuk Lee (Myongji University)H-Index: 2
Last. Nokyoung Park (Myongji University)H-Index: 18
view all 8 authors...
RNA interference (RNAi) is a mechanism in which small interfering RNA (siRNA) silences a target gene. Herein, we describe a DNA hydrogel capable of producing siRNA and interfering with protein expression. This RNAi-exhibiting gel (termed I-gel for interfering gel) consists of a plasmid carrying the gene transcribing siRNA against the target mRNA as part of the gel scaffold. The RNAi efficiency of the I-gel has been confirmed by green fluorescent protein (GFP) expression assay and RNA production ...
18 CitationsSource
#1Seunghyun Lee (POSTECH: Pohang University of Science and Technology)H-Index: 9
#2Owoong Kwon (SKKU: Sungkyunkwan University)H-Index: 6
Last. Chulhong Kim (POSTECH: Pohang University of Science and Technology)H-Index: 60
view all 13 authors...
Super-resolution microscopy based on light-activated atomic force microscopy has been demonstrated a team in Korea. The diffraction limit makes it difficult to image structures smaller than about 200 nanometres using optical microscopy. While several super-resolution fluorescence microscopy techniques have been realized, there is a need for a super-resolution technique that does not use fluorescent dyes. Chulhong Kim of Pohang University of Science and Technology in Korea and co-workers have rea...
18 CitationsSource
#1Jaejung Song (POSTECH: Pohang University of Science and Technology)H-Index: 12
#2Sungmin Park (Myongji University)H-Index: 2
Last. Nokyoung Park (Myongji University)H-Index: 18
view all 5 authors...
Here we show that well-defined three dimensional DNA nanostructures can be synthesized from branched DNAs via hybridization and enzymatic ligation. The fabricated triangular pyramid DNA has been employed as a template for assembly of AuNPs. The electrostatic attraction between DNA structures and AuNPs has shown nonspecific assembly behavior and allowed the plasmonic absorption peaks of the assembled nanocomposites to be tuned from visible to near infrared by simple control of the mixing ratio.
3 CitationsSource
#1Sanghwa JeongH-Index: 11
#2Jaejung SongH-Index: 12
Last. Sungjee KimH-Index: 48
view all 10 authors...
Recent technological advances have expanded fluorescence (FL) imaging into the second near-infrared region (NIR-II; wavelength = 1000–1700 nm), providing high spatial resolution through deep tissues. However, bright and compact fluorophores are rare in this region, and sophisticated control over NIR-II probes has not been fully achieved yet. Herein, we report an enzyme-activatable NIR-II probe that exhibits FL upon matrix metalloprotease activity in tumor microenvironment. Bright and stable PbS/...
40 CitationsSource
#1Jaejung Song (POSTECH: Pohang University of Science and Technology)H-Index: 12
#2Jeesu Kim (POSTECH: Pohang University of Science and Technology)H-Index: 18
Last. Sungjee Kim (POSTECH: Pohang University of Science and Technology)H-Index: 48
view all 7 authors...
‘Smart’ gold nanoparticles can respond to mild acidic environments, rapidly form aggregates, and shift the absorption to red and near-infrared. They were used as a photoacoustic imaging agent responsive to the cancer microenvironment, and have demonstrated the cancer-specific accumulation at the cellular level and an amplified signal which is twice higher than the control in vivo.
47 CitationsSource
#1Jaejung Song (POSTECH: Pohang University of Science and Technology)H-Index: 12
#2Sekyu Hwang (POSTECH: Pohang University of Science and Technology)H-Index: 17
Last. Nokyoung Park (Myongji University)H-Index: 18
view all 9 authors...
Herein, we show that DNA nanostructures have great potential as templates for the synthesis of shape-controlled metal nanostructures. In specific, branch-shaped gold nanostructures, which show broad absorption in near the infrared region and have high efficacy in photothermal cancer cell treatment, have been successfully synthesized by using X-shaped and Y-shaped DNA as templates.
4 CitationsSource
#1Seunghyun Lee (POSTECH: Pohang University of Science and Technology)H-Index: 9
#2Owoong Kwon (SKKU: Sungkyunkwan University)H-Index: 6
Last. Chulhong Kim (POSTECH: Pohang University of Science and Technology)H-Index: 60
view all 9 authors...
Photoacoustic imaging (PAI) is an emerging hybrid imaging modality that can provide a strong optical absorption contrast using the photoacoustic (PA) effect, and breaks through the fundamental imaging depth limit of existing optical microscopy such as optical coherence tomography (OCT), confocal or two-photon microscopy. In PAI, a short-pulsed laser is illuminated to the tissue, and the PA waves are generated by thermoelastic expansion. Despite the high lateral resolution of optical-resolution p...
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#1Jutaek NamH-Index: 21
#2Sungwook JungH-Index: 11
view all 5 authors...