Luca Possenti
Polytechnic University of Milan
Porous mediumSurface modificationLigand (biochemistry)VasodilationPermeability (electromagnetism)PhysicsBiophysicsTopologyMicrocirculationFinite element methodConfocalBiomedical engineeringPathologyAerospace engineeringCellNanoparticleFåhræus–Lindqvist effectNeuroscienceVolumetric flow rateIntensive care medicineLymphatic systemNanocarriersIsotropyTopology (electrical circuits)ChemistryBiological systemLimitingMaterials scienceCapillary actionNetwork topologyIn vitroIn vivoAcousticsIn silicoUremiaInflammationHuman brainBlood–brain barrierOrgan dysfunctionDilemmaOutcome (probability)AerosolExtravasationInterstitial fluidMouthpieceComputational analysisDirect samplingGlobal sensitivity analysisIntradialytic hypotensionMembrane permeabilityInterstitial pressureFluid exchangeMolecular sizeVascular networkIn vitro modelNormal tissueHealthy tissueClinical scenarioFluid homeostasisHuman bloodMicrovascular flowA determinantMoleculeMathematicsEnvironmental scienceComputer scienceCancer researchRadiation therapyMechanicsHydraulic conductivityComputational modelMedicineFlow (psychology)PlasmaMicrofluidicsPharmacologyDistribution (pharmacology)
18Publications
4H-index
75Citations
Publications 17
Newest
#1Luca Possenti (Polytechnic University of Milan)H-Index: 4
Last. Matteo MorettiH-Index: 30
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Ionizing radiation (IR) is used in radiotherapy as a treatment to destroy cancer. Such treatment also affects other tissues, resulting in the so-called normal tissue complications. Endothelial cells (ECs) composing the microvasculature have essential roles in the microenvironment’s homeostasis (ME). Thus, detrimental effects induced by irradiation on ECs can influence both the tumor and healthy tissue. In-vitro models can be advantageous to study these phenomena. In this systematic review, we an...
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#1Luca Possenti (Polytechnic University of Milan)H-Index: 4
#2S. Di Gregorio (Polytechnic University of Milan)
Last. Paolo Zunino (Polytechnic University of Milan)H-Index: 27
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A global sensitivity analysis of a multiscale computational model of microvascular flow is presented. A total of 140 simulations have been completed and analyzed varying 6 input parameters and considering their effects on 7 output variables. Interestingly, the vascular network topology has been found as a determinant factor for both vasculature-related and interstitium-related quantities. Regarding the firsts, the vascular network topology has obtained a score of 5.5/6 and 6/6 for average and sp...
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#2Federica Laurino (Polytechnic University of Milan)H-Index: 2
Last. Paolo Zunino (Polytechnic University of Milan)H-Index: 27
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Abstract Background Radiation-induced organ dysfunction are frequently described by Normal Tissue Complication Probability models. The approximations of this radiobiological approach do not allow to consider the important role played by the microvasculature not only in the dose–response of the blood vessels but also of the organs where it is located. To this purpose, we presented a computational model that describes the fluid dynamics of microcirculation when the parameters of the network and th...
1 CitationsSource
#1Sharon Wei Ling Lee (Singapore–MIT alliance)H-Index: 5
#2Marco Campisi (Polytechnic University of Turin)H-Index: 8
Last. Valeria Chiono (Polytechnic University of Turin)H-Index: 31
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#1Sharon Wei Ling Lee (Singapore–MIT alliance)H-Index: 5
#2Marco Campisi (Polytechnic University of Turin)H-Index: 8
Last. Valeria Chiono (Polytechnic University of Turin)H-Index: 31
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Polymer nanoparticles (NPs), due to their small size and surface functionalization potential have demonstrated effective drug transport across the blood-brain-barrier (BBB). Currently, the lack of in vitro BBB models that closely recapitulate complex human brain microenvironments contributes to high failure rates of neuropharmaceutical clinical trials. In this work, a previously established microfluidic 3D in vitro human BBB model, formed by the self-assembly of human-induced pluripotent stem ce...
16 CitationsSource
#1Marco Campisi (Polytechnic University of Turin)H-Index: 8
#2Sharon Wei Ling Lee (Singapore Immunology Network)H-Index: 5
Last. Roger D. Kamm (MIT: Massachusetts Institute of Technology)H-Index: 107
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The blood-brain barrier (BBB) protects the brain from pathogens but also hinders drug delivery to the central nervous system. Most of the BBB models developed up to date failed to reproduce the human anatomical complexity of brain barriers, contributing to less predictive experimental platforms and poor patient outcomes. To overcome those limitations, the development of reliable in vitro models represents a crucial step towards more effective therapies. This contribution was focused on the devel...
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#1Giovanni S. Offeddu (MIT: Massachusetts Institute of Technology)H-Index: 11
#2Luca Possenti (Polytechnic University of Milan)H-Index: 4
Last. Roger D. Kamm (MIT: Massachusetts Institute of Technology)H-Index: 107
view all 9 authors...
1 CitationsSource
#1Giovanni S. Offeddu (MIT: Massachusetts Institute of Technology)H-Index: 11
#2Luca Possenti (Polytechnic University of Milan)H-Index: 4
Last. Roger D. Kamm (MIT: Massachusetts Institute of Technology)H-Index: 107
view all 9 authors...
: In vitro prediction of physiologically relevant transport of therapeutic molecules across the microcirculation represents an intriguing opportunity to predict efficacy in human populations. On-chip microvascular networks (MVNs) show physiologically relevant values of molecular permeability, yet like most systems, they lack an important contribution to transport: the ever-present fluid convection through the endothelium. Quantification of transport through the MVNs by current methods also requi...
18 CitationsSource
#1Luca Possenti (Polytechnic University of Milan)H-Index: 4
#2Giustina Casagrande (Polytechnic University of Milan)H-Index: 7
Last. Maria Laura Costantino (Polytechnic University of Milan)H-Index: 14
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Abstract Fluid homeostasis is required for life. Processes involved in fluid balance are strongly related to exchanges at the microvascular level. Computational models have been presented in the literature to analyze the microvascular-interstitial interactions. As far as we know, none of those models consider a physiological description for the lymphatic drainage-interstitial pressure relation. We develop a computational model that consists of a network of straight cylindrical vessels and an iso...
15 CitationsSource
#1Luca Possenti (Polytechnic University of Milan)H-Index: 4
#2Simone Di Gregorio (Polytechnic University of Milan)H-Index: 3
Last. Paolo Zunino (Polytechnic University of Milan)H-Index: 27
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: We present a two-phase model for microcirculation that describes the interaction of plasma with red blood cells. The model takes into account of typical effects characterizing the microcirculation, such as the Fahraeus-Lindqvist effect and plasma skimming. Besides these features, the model describes the interaction of capillaries with the surrounding tissue. More precisely, the model accounts for the interaction of capillary transmural flow with the surrounding interstitial pressure. Furthermo...
13 CitationsSource