Saixia Zhang
Guangzhou University of Chinese Medicine
Gene silencingInternal medicineDownregulation and upregulationEndocrinologyNeural stem cellDopaminergicSurgeryPathologymicroRNACellular differentiationCellMolecular biologyTyrosine hydroxylaseCalcitriol receptorTumor necrosis factor alphaChemistryApoptosisMesenchymal stem cellIn vivoSmall interfering RNANeuroprotectionInflammationOsteoblastLipopolysaccharidePaeonolHMGB1PathogenesisOncogenePulmonary fibrosisLung injurySecretionTransfectionSignal transductionMedicineTranscription factorBiologyCell biologyPharmacology
21Publications
8H-index
207Citations
Publications 21
Newest
#1Sen Ye (Guangzhou University of Chinese Medicine)H-Index: 2
#2Jun Zhong (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Caixia Li (Guangzhou University of Chinese Medicine)
view all 7 authors...
Abstract In this paper, we report the results of treating cells with an effective small molecule, (+)4-cholesten-3-one (PubChem CID: 91477), which can promote neural stem cell(NSC) differentiation into dopaminergic neurons. This study used rat neural stem cells stimulated with two different concentrations (7.8 μM and 78 μM) of (+)4-cholesten-3-one. Cell phenotypic analysis showed that (+)4-cholesten-3-one induced NSC differentiation into dopaminergic neurons, and the level of tyrosine hydroxylas...
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#1Hao Pan (Guangzhou University of Chinese Medicine)H-Index: 2
#2Yuqing Lin (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 12 authors...
OBJECTIVES Wedelolactone exhibits regulatory effects on some inflammatory diseases. However, the anti-inflammatory mechanism of wedelolactone has not been entirely unravelled. Therefore, the present study focuses on investigating the mechanism of wedelolactone on NLRP3 inflammasome in macrophages and its influence on MSU-induced inflammation. MATERIALS AND METHODS BMDM, J774A.1 and PMA-differentiated THP-1 macrophages were primed with LPS and then stimulated with ATP or nigericin or MSU crystal ...
9 CitationsSource
#1Jun Zhong (Guangzhou University of Chinese Medicine)H-Index: 1
#2Sen Ye (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Caixia Li (Guangzhou University of Chinese Medicine)
view all 9 authors...
In recent years, stem cells have gained much attention for the treatment of neurodegenerative diseases. However, inducing neural stem cell directionally differentiation is a difficult problem in the treatment of Parkinson's disease (PD) by stem cell therapy. Plastrum Testudinis (PT) can enhance the number of TH-positive neurons in the PD rat brain substantia nigra, but the underlying mechanism has not been clarified. Here, we aimed at further investigating the mechanism by which PT can promote N...
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#1Xia Liu (Guida: Guizhou University)H-Index: 2
#2Fei Ai (Guida: Guizhou University)H-Index: 1
Last. Junfeng Guo (Guida: Guizhou University)H-Index: 1
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Shenfu injection (SFI), a Chinese herbal medicine with substances extracted from Ginseng Radix et Rhizoma Rubra and Aconiti Lateralis Radix Praeparata, is widely used as an anti-inflammatory reagent to treat endotoxin shock in China. However, the mechanism of SFI in endotoxin shock remains to be illuminated. High mobility group box 1 (HMGB1), a vital inflammatory factor in the late stage of endotoxin shock, may stimulate multiple signalling cascades, including κB (NF-κB), a nuclear transcription...
9 CitationsSource
#1Xin Liu (Guangzhou University of Chinese Medicine)H-Index: 2
#2Ruilin Zhang (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 8 authors...
: Forkhead box P2 (Foxp2) is a transcription factor involved in vocal learning. However, the number of previous studies that have investigated the role of Foxp2 in early vascular dementia (VD) is limited. The aim of the present study was to determine whether microRNA (miR)‑134‑5p/Foxp2 contributes to cognitive impairment in a chronic ischemia‑induced early VD model. miR‑134‑5p was found to be significantly increased in the cortex in a rat VD model. Intracerebroventricular injection of miR‑134‑5p...
4 CitationsSource
#1Xiang-Jun Li (Guangzhou University of Chinese Medicine)H-Index: 1
#2Fangfang Xie (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Aijun Liu (Guangzhou University of Chinese Medicine)H-Index: 3
view all 9 authors...
: Genomic DNA demethylation is important for mammalian embryonic development and organ function. 5-Hydroxymethylcytosine (5hmC) is considered a novel epigenetic marker. Ten-eleven translocation (TET) enzymes convert 5-methylcytosine (5mC) to 5hmC. To explore the dynamic changes of epigenetic modifications during organogenesis in the late mouse fetus, the regional distribution and histological localization of 5hmC and TET enzymes was investigated by immunohistochemical method. The liver of mouse ...
1 CitationsSource
#1Wenwen Si (Guangzhou University of Chinese Medicine)H-Index: 4
#2Shanyu Ye (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 11 authors...
: Under harmful environmental conditions, stress granules (SGs), macromolecular aggregates that are associated with cell survival and death, are produced in the eukaryotic cytoplasm. However, whether and how microRNAs (miRNAs/miRs) modulate SG formation induced by acute ischemic stroke has not been investigated. In the present study, a rat model of middle cerebral artery occlusion (MCAO) was utilized and miRNA array profiling and reverse transcription‑quantitative polymerase chain reaction were p...
14 CitationsSource
#1Qiuke Hou (Guangzhou University of Chinese Medicine)H-Index: 7
#2Yongquan Huang (Guangzhou University of Chinese Medicine)H-Index: 6
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 9 authors...
Our previous study showed that (+)-cholesten-3-one (CN) has the potential to induce the osteoblastic differentiation of mesenchymal stem cells (MSCs). However, the roles of CN in targeting miRNA-mRNA-lncRNA interactions to regulate osteoblast differentiation remain poorly understood. A total of 77 miRNAs (36 upregulated and 41 downregulated) and 295 lncRNAs (281 upregulated and 14 downregulated) were significantly differentially expressed during CN-induced MSC osteogenic differentiation. Bioinfo...
11 CitationsSource
#1Xiang-Jun Li (Guangzhou University of Chinese Medicine)H-Index: 1
#2Yuqiong Wu (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Aijun Liu (Guangzhou University of Chinese Medicine)H-Index: 3
view all 8 authors...
: Our previous study indicated that loureirin A induces hair follicle stem cell (HFSC) differentiation through Wnt/β‑catenin signaling pathway activation. However, if and how microRNAs (miRNAs/miRs) modulate loureirin A‑induced differentiation remains to be elucidated. In the present study, HFSCs were separated from the vibrissae of rats and identified by CD34 and keratin, type 1 cytoskeletal (K)15 expression. Microarray‑based miRNA profiling analysis revealed that miR‑339‑5p was downregulated i...
9 CitationsSource
#1Xia Liu (Guangzhou University of Chinese Medicine)H-Index: 4
#2Qin Xu (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Hui Li (Guangzhou University of Chinese Medicine)H-Index: 17
view all 15 authors...
Abstract High-mobility group box 1 (HMGB1) is a highly conserved DNA-binding nuclear protein that facilitates gene transcription and the DNA repair response. However, HMGB1 may be released by necrotic cells as well as activated monocytes and macrophages following stimulation with lipopolysaccharide (LPS), interleukin-1β (IL-1β), or tumor necrosis factor-α (TNF-α). Extracellular HMGB1 plays a critical role in the pathogenesis of acute lung injury (ALI) through activating the nuclear transcription...
15 CitationsSource