Henrik Thorlacius
Lund University
Internal medicineChemokineEndocrinologySurgeryPathologyChemistryImmunologyMyeloperoxidaseAcute pancreatitisInflammationLungSepsisIntravital microscopyLeukocyte RollingLung injuryMedicineBiologyPlateletGastroenterologyPharmacology
312Publications
50H-index
5,424Citations
Publications 314
Newest
Lung endothelial cell dysfunction plays a central role in septic-induced lung injury. We hypothesized that endothelial cell subsets, capillary endothelial cells (capEC) and post capillary venules (PCV), might play different roles in regulating important pathophysiology in sepsis. In order to reveal global transcriptomic changes in endothelial cell subsets during sepsis, we induced sepsis in C57BL/6 mice by cecal ligation and puncture (CLP). We confirmed that CLP induced systemic and lung inflamm...
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#1Victoria Arthursson (Lund University)H-Index: 1
#2Roberto Rosén (Lund University)
Last. Carl-Fredrik Rönnow (Lund University)H-Index: 4
view all 8 authors...
Background and study aims Management of T1 rectal cancer is complex and includes several resection methods, making cost comparisons challenging. The aim of this study was to compare costs of endoscopic and surgical resection and to investigate hypothetical cost scenarios for the treatment of T1 rectal cancer. Patients and methods Retrospective population-based cost minimization study on prospectively collected data on T1 rectal cancer patients treated using endoscopic submucosal dissection (ESD)...
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#1Martina Sjöbeck (Lund University)
#2Hanna Sternby (Lund University)H-Index: 6
Last. Sara Regnér (Lund University)H-Index: 24
view all 5 authors...
Background null Most patients with acute pancreatitis (AP) experience mild, self-limiting disease with little or no need for hospital care. However, 20-25% of patients develop a more severe and potentially life-threatening condition with progressive systemic inflammatory response syndrome (SIRS) and multiorgan failure, resulting in high morbidity and mortality rates. Predicting disease severity at an early stage is important, as immediate supportive care has been demonstrated to reduce the incid...
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#1Umama Khan (Khulna University)H-Index: 1
#2Sabrina Chowdhury (North South University)
Last. Milladur RahmanH-Index: 20
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Neutrophils form sticky web-like structures known as neutrophil extracellular traps (NETs) as part of innate immune response. NETs are decondensed extracellular chromatin filaments comprising nuclear and cytoplasmic proteins. NETs have been implicated in many gastrointestinal diseases including colorectal cancer (CRC). However, the regulatory mechanisms of NET formation and potential pharmacological inhibitors in the context of CRC have not been thoroughly discussed. In this review, we intend to...
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#1Avin Hawez (Lund University)H-Index: 2
#2Dler Taha (Lund University)H-Index: 2
Last. Henrik Thorlacius (Lund University)H-Index: 50
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Neutrophil extracellular traps (NETs)-mediated tissue damage is a hallmark in abdominal sepsis. Under certain conditions, microRNAs (miRs) can regulate protein expression and cellular functions. The aim of this study was to investigate the role of miR-155 in sepsis-induced NET formation, lung inflammation, and tissue damage. Abdominal sepsis was induced in wild-type (WT) C57BL/6 and miR-155 gene-deficient mice by cecal ligation and puncture (CLP). The amount of DNA-histone complex formation as w...
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#1Mattias Lepsenyi (Lund University)H-Index: 4
#2Nader Algethami (Lund University)H-Index: 1
Last. Henrik Thorlacius (Lund University)H-Index: 50
view all 7 authors...
Peritoneal metastasis is an insidious aspect of colorectal cancer. The aim of the present study was to define mechanisms regulating colon cancer cell adhesion and spread to peritoneal wounds after abdominal surgery. Mice was laparotomized and injected intraperitoneally with CT-26 colon carcinoma cells and metastatic noduli in the peritoneal cavity was quantified after treatment with a CXCR2 antagonist or integrin-αV-antibody. CT-26 cells expressed cell surface chemokine receptors CXCR2, CXCR3, C...
1 CitationsSource
#1Sergio Cadoni (CTO Hospital)H-Index: 13
#2Sauid Ishaq (BCU: Birmingham City University)H-Index: 12
Last. Felix W. Leung (UCLA: University of California, Los Angeles)H-Index: 51
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Background and Aims Since 2008, a plethora of research studies has compared the efficacy of water-assisted (aided) colonoscopy (WAC) and underwater resection (UWR) of colorectal lesions with standard colonoscopy. We reviewed and graded the research evidence with potential clinical application. We conducted a modified Delphi consensus among experienced colonoscopists on definitions and practice of water immersion (WI), water exchange (WE), and UWR. Methods Major databases were searched to obtain ...
4 CitationsSource
#1Hanna Sternby (Lund University)H-Index: 6
#2Hannes Hartman (Lund University)H-Index: 6
Last. Sara Regnér (Lund University)H-Index: 24
view all 4 authors...
Clinical reports on early immune dysregulation in acute pancreatitis (AP) are scarce. Herein we investigate the initial temporal development of selected biomarkers. Blood samples were taken at 0-24 and 25-48 h after onsets of AP were acquired. Mean values and temporal intermediate difference (delta-values) of IL-1β, IL-6, IL-8, IL-10, IL-12, IFN-γ and TNF-α were calculated. Differences between severity groups, predictive capacity of the biomarkers and association with severe disease were analyze...
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#1T Axmarker (Lund University)
#2M Leffler (Lund University)
Last. Ingvar Syk (Lund University)H-Index: 24
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Aim Self-expanding metallic stents (SEMS) as bridge to surgery have been questioned due to the fear of perforation and tumour spread. This study aimed to compare SEMS and stoma as bridge to surgery in acute malignant large bowel obstruction in the Swedish population. Method Medical records of patients identified via the Swedish Colorectal Cancer Register 2007-2009 were collected and scrutinized. The inclusion criterion was decompression intended as bridge to surgery due to acute malignant large ...
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#1Victoria Arthursson (Lund University)H-Index: 1
#2R Rosén (Lund University)
Last. Carl-Fredrik Rönnow (Lund University)H-Index: 4
view all 8 authors...
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